{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:29:40Z","timestamp":1785796180940,"version":"3.56.0"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>We aim to assess the efficacy of rapid local ischemic postconditioning (RL-IPostC) following successful reperfusion in patients with acute ischemic stroke with anterior circulation large vessel occlusion who underwent endovascular thrombectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We conducted an ambidirectional cohort study with 78 prospectively enrolled patients with RL-IPostC and endovascular thrombectomy and 129 retrospectively enrolled patients with endovascular thrombectomy. The RL-IPostC procedure involved 5 cycles of 15-s balloon inflation and deflation in the ipsilateral internal carotid artery. The primary outcome was functional independence, defined as a modified Rankin Scale score of 0 to 2. Secondary outcomes included excellent outcomes (modified Rankin Scale score, 0\u20131) and early therapeutic response. Imaging outcomes involved infarct volume changes and cerebral edema measurements. Outcomes were compared with postpropensity score matching (1:1) and assessed using univariable and multivariable regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              In the matched cohort of 136 patients (mean age, 71\u00b114 years; 70 men [51%]), RL-IPostC was associated with a higher rate of functional independence (adjusted odds ratio, 2.47 [95% CI, 1.10\u20135.68];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.030). The RL-IPostC group exhibited significantly reduced infarct volumes at 24 hours (difference, \u221212.2 [95% CI, \u221223.9 to \u22120.53];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.041) and less infarct growth (difference, \u221212.2 [95% CI, \u221223.9 to \u22120.45];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.042). Furthermore, RL-IPostC correlated with lower increases in net water uptake (difference, \u22120.04 [95% CI, \u22120.07 to \u22120.01];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.018), lower decrease cerebrospinal fluid volume (difference, \u22127.75 [95% CI, \u221211.7 to \u22123.84];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001), and reduced midline shift at 24 hours (difference, \u22121.39 [95% CI, \u22122.48 to \u22120.30];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.013).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>RL-IPostC tends to promote functional independence and reduces infarct growth and cerebral edema in patients with acute ischemic stroke post-reperfusion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.124.047674","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:00:39Z","timestamp":1731319239000},"page":"2896-2900","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Neuroprotective Effects of Rapid Local Ischemic Postconditioning in Successful Endovascular Thrombectomy Patients"],"prefix":"10.1161","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-5979","authenticated-orcid":true,"given":"Jiangshan","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Radiology (J.D., G.H., L.W., H.L., Y.Z.), Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China."},{"name":"Department of Neurology (J.D.), Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.D., G.H., L.W., H.L., Y.Z.), Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-5844","authenticated-orcid":true,"given":"Tingyu","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, Zhangzhou Affiliated Hospital of Fujian Medical University, China (T.Y., W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.D., G.H., L.W., H.L., Y.Z.), Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.D., G.H., L.W., H.L., Y.Z.), Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Shanghai United Imaging Intelligence Co, Ltd, China (Q.Z., H.Y., Y.S., F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-8942","authenticated-orcid":true,"given":"Ye","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Public Health, Fudan University, Shanghai, China (Y.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-549X","authenticated-orcid":true,"given":"Chengcheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology (C.Z., M.M.-B.), University of Washington, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-3347","authenticated-orcid":true,"given":"Michael R.","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (M.R.L.), University of Washington, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7798-8158","authenticated-orcid":true,"given":"Mahmud","family":"Mossa-Basha","sequence":"additional","affiliation":[{"name":"Department of Radiology (C.Z., M.M.-B.), University of Washington, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Shanghai United Imaging Intelligence Co, Ltd, China (Q.Z., H.Y., Y.S., F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Shanghai United Imaging Intelligence Co, Ltd, China (Q.Z., H.Y., Y.S., F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-9943","authenticated-orcid":true,"given":"Feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Shanghai United Imaging Intelligence Co, Ltd, China (Q.Z., H.Y., Y.S., F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-2464","authenticated-orcid":true,"given":"Duolao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom (D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-9846","authenticated-orcid":true,"given":"Longting","family":"Lin","sequence":"additional","affiliation":[{"name":"South West Sydney Clinical School, University of New South Wales, Australia (L.L., M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8874-2487","authenticated-orcid":true,"given":"Mark","family":"Parsons","sequence":"additional","affiliation":[{"name":"South West Sydney Clinical School, University of New South Wales, Australia (L.L., M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-8917","authenticated-orcid":true,"given":"Wenhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurointervention, Zhangzhou Affiliated Hospital of Fujian Medical University, China (T.Y., W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-9075","authenticated-orcid":true,"given":"Yueqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.D., G.H., L.W., H.L., Y.Z.), Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.044060"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108921"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.558122"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0196-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.507939"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.124.047674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T14:53:46Z","timestamp":1748530426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.124.047674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1161\/STROKEAHA.124.047674"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.124.047674","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}