{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:17:45Z","timestamp":1788635865152,"version":"build-2803163510"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Lp(a) (lipoprotein[a]) is a risk factor for cardiovascular disease; however, its association with cerebrovascular disease is not as well established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Data from a population-based cohort of Hispanics\/Latinos included 16\u2005333 individuals with baseline Lp(a) levels (nmol\/L) and self-reported prevalent stroke or transient ischemic attack (TIA). A subset of 2642 individuals with brain magnetic resonance imaging was also included. Linear and multivariate logistic regression assessed the association of Lp(a) with (1) self-reported stroke or TIA, (2) cerebral injury defined as self-reported stroke or TIA or evidence of a stroke on brain magnetic resonance imaging, (3) white matter hyperintensity volume, and (4) silent brain infarcts. Sampling weights were utilized given the HCHS\/SOL (Hispanic Community Health Study\/Study of Latinos) complex sample design.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Mean age\u00b1SE was 41.1\u00b10.3 years, 52.0% women, and median interquartile range (Q\n              <jats:sub>1<\/jats:sub>\n              , Q\n              <jats:sub>3<\/jats:sub>\n              ) Lp(a) level of 19.7 (7.3\u201360.6) nmol\/L; brain magnetic resonance imaging subset mean age\u00b1SE was 49.9\u00b10.4 years, 56.4% women, and median (interquartile range) Lp(a) level of 21.7 (8.1\u201362.9) nmol\/L. Each unit increase in log-transformed Lp(a) was associated with higher odds of self-reported stroke or TIA (odds ratio, 1.13 [95% CI, 1.01\u20131.27];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.03). Lp(a) levels in the highest quintile (&gt;77 nmol\/L) were significantly associated with higher odds of prevalent stroke or TIA compared with Lp(a) &lt;6 nmol\/L (first quintile: odds ratio, 1.74 [95% CI, 1.09\u20132.77];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.02). The highest proportion of cerebral injury was noted in Q5, while the lowest proportion was noted in Q2. When comparing Lp(a) &gt;77 nmol\/L with Lp(a) of 6 to &lt;13 nmol\/L (second quintile), a significant association was found between Lp(a) and cerebral injury that persisted after fully adjusted models (odds ratio, 2.03 [95% CI, 1.05\u20133.93];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.03). Each unit increase in log-Lp(a) was associated with a 0.10 increase in log-white matter hyperintensity (\u03b2, 0.10;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.005). No significant association was found between Lp(a) and silent brain infarcts.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Lp(a) is independently and significantly associated with prevalent stroke\/TIA, and white matter hyperintensity, in a large diverse population of Hispanics\/Latinos.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.124.048439","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T09:01:17Z","timestamp":1743498077000},"page":"1492-1504","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Lp(a) With Stroke and Cerebral Injury on MRI: Insights From the HCHS\/SOL (Hispanic Community Health Study\/Study of Latinos) and Investigation of Neurocognitive Aging MRI (SOL-INCA MRI)"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-0568","authenticated-orcid":true,"given":"Akhil Avunoori","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (A.A.C.), Montefiore Medical Center, Bronx, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-2941","authenticated-orcid":true,"given":"Priscilla","family":"Duran Luciano","sequence":"additional","affiliation":[{"name":"Department of Medicine (P.D.L., K.S., C.J.R.), Albert Einstein College of Medicine, Bronx, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Swett","sequence":"additional","affiliation":[{"name":"Department of Medicine (P.D.L., K.S., C.J.R.), Albert Einstein College of Medicine, Bronx, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-4615","authenticated-orcid":true,"given":"Robert","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health (R.K., C.J.R.), Albert Einstein College of Medicine, Bronx, NY."},{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA (R.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-1107","authenticated-orcid":true,"given":"Gregory A.","family":"Talavera","sequence":"additional","affiliation":[{"name":"Department of Psychology, San Diego State University, Chula Vista, CA (G.A.T., L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-5543","authenticated-orcid":true,"given":"Melissa","family":"Lamar","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University, Chicago, IL (M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Tarraf","sequence":"additional","affiliation":[{"name":"Institute of Gerontology &amp; Department of Healthcare Sciences, Wayne State University, Detroit, MI (W.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-9225","authenticated-orcid":true,"given":"Freddie","family":"Marquez","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California San Diego, La Jolla (F.M., H.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-2794","authenticated-orcid":true,"given":"Parag H.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas (P.H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-5888","authenticated-orcid":true,"given":"Linda","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Psychology, San Diego State University, Chula Vista, CA (G.A.T., L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3226-6140","authenticated-orcid":true,"given":"Daniela","family":"Sotres-Alvarez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of North Carolina, Chapel Hill (D.S.-A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-3015","authenticated-orcid":true,"given":"Morgan","family":"Gianola","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of California San Diego, La Jolla (M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-8727","authenticated-orcid":true,"given":"Martha L.","family":"Daviglus","sequence":"additional","affiliation":[{"name":"Institute for Minority Health Research, University of Illinois College of Medicine at Chicago (M.L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-4345","authenticated-orcid":true,"given":"Daniel L.","family":"Labovitz","sequence":"additional","affiliation":[{"name":"Division of Vascular Neurology (D.L.L.), Montefiore Medical Center, Bronx, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-7902","authenticated-orcid":true,"given":"Hector","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California San Diego, La Jolla (F.M., H.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-2693","authenticated-orcid":true,"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Neuroscience, University of California Davis Medical Center, Sacramento (C.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0860-9008","authenticated-orcid":true,"given":"Carlos J.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Medicine (P.D.L., K.S., C.J.R.), Albert Einstein College of Medicine, Bronx, NY."},{"name":"Department of Epidemiology &amp; 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