{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:24:56Z","timestamp":1791584696828,"version":"4.3.4"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"name":"Stryker Neurovascular"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Underlying intracranial stenosis is the most common cause of failed mechanical thrombectomy in patients with acute ischemic stroke with large vessel occlusion. Adjunct emergent stenting is sometimes performed to improve or maintain reperfusion, despite limited data regarding its safety or efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a prospective multicenter observational international cohort study. Patients were enrolled between January 2022 and December 2023 at 25 thrombectomy-capable centers in North America, Europe, and Asia. Consecutive patients treated with mechanical thrombectomy were included if they were identified as having underlying intracranial stenosis, defined as 50% to 99% residual stenosis of the target vessel or intraprocedural reocclusion. The primary outcome was functional independence, defined as a modified Rankin Scale score of 0 to 2 at 90 days. After applying inverse probability of treatment weighting based on propensity scores, we compared outcomes among patients who underwent adjunct emergent intracranial stenting (stenting) versus those who received mechanical thrombectomy alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 417 patients were included: 218 patients treated with mechanical thrombectomy alone (168 anterior circulation) and 199 with mechanical thrombectomy plus stenting (144 anterior circulation). Patients in the stenting group were less likely to be non-Hispanic White (51.8% versus 62.4%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03) and less likely to have diabetes (33.2% versus 43.1%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.037) or hyperlipidemia (43.2% versus 56%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.009). In addition, there was a lower rate of IV thrombolysis use in the stenting group (18.6% versus 27.5%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03). There was a higher rate of successful reperfusion (modified Treatment in Cerebral Infarction score \u22652B) in the stenting versus mechanical thrombectomy\u2013alone group (90.9% versus 77.9%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and a higher rate of a 24-hour infarct volume of &lt;30 mL (n=260, 67.9% versus 50.3%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.005). The overall complication rate was higher in the stenting group (12.6% versus 5%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.006), but there was not a significant difference in the rate of symptomatic hemorrhage (9% versus 5.5%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.162). Functional independence at 90 days was significantly higher in the stenting group (42.2% versus 28.4%, adjusted odds ratio, 2.67 [95% CI, 1.66\u20134.32]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with underlying stenosis who achieved reperfusion with mechanical thrombectomy, adjunct emergent stenting was associated with better functional outcome without a significantly increased risk of symptomatic hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT05403593.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.124.049038","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T13:20:32Z","timestamp":1732281632000},"page":"390-400","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry"],"prefix":"10.1161","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct05403593","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-9761","authenticated-orcid":true,"given":"Sami","family":"Al Kasab","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Medical University of South Carolina, Charleston (S.A.K., A.M.S., K.K., J.L., O.L., Z.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-7901","authenticated-orcid":true,"given":"Eyad","family":"Almallouhi","sequence":"additional","affiliation":[{"name":"Neurointerventional Surgery, Sarasota Memorial Hospital, FL (E.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-797X","authenticated-orcid":true,"given":"Mohammad","family":"Jumaa","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH (M.J., A.M., S.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-3346","authenticated-orcid":true,"given":"Violiza","family":"Inoa","sequence":"additional","affiliation":[{"name":"Semmes Murphey Clinic, University of Tennessee Health Science Center, Memphis (V.I., N.G., R.E.-G., V.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-6092","authenticated-orcid":true,"given":"Francesco","family":"Capasso","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Careggi University Hospital, Florence, Italy (F.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8198-7676","authenticated-orcid":true,"given":"Michael","family":"Nahhas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas, Houston (M. Nahhas, H.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Starke","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (R.M.S., A. Abdelsalam), University of Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-7458","authenticated-orcid":true,"given":"Isabel","family":"Fragata","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Hospital S. Jos\u00e9, ULS, Lisbon, Portugal (I.F., C.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Rochester Medical Center, NY (M.B., T.K.M., D.A.S., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (K.M.), Warren Alpert Medical School of Brown University, Providence, RI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-1004","authenticated-orcid":true,"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Department of Neurology (S.Y., A.C.), Warren Alpert Medical School of Brown University, Providence, RI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-8878","authenticated-orcid":true,"given":"Ilko","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medicine Goettingen, Germany (I.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-8826","authenticated-orcid":true,"given":"Jonathan A.","family":"Grossberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Emory University, Atlanta, GA (J.A.G., A. Alawieh, Y.M.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-2413","authenticated-orcid":true,"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA (P.J., S.T., K.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-414X","authenticated-orcid":true,"given":"Marios","family":"Psychogios","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Switzerland (M.P., N.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-2268","authenticated-orcid":true,"given":"Edgar A.","family":"Samaniego","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City (E.A.S., A.S.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-0313","authenticated-orcid":true,"given":"Jan-Karl","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pennsylvania, Philadelphia (J.-K.B., B.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-0763","authenticated-orcid":true,"given":"Brian","family":"Jankowitz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pennsylvania, Philadelphia (J.-K.B., B.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Abdalkader","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (M. Abdalkader, T.N.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-7616","authenticated-orcid":true,"given":"Ameer E.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Valley Baptist Medical Center, Harlingen, TX (A.E.H., S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5130-1378","authenticated-orcid":true,"given":"David","family":"Altschul","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (D.A., M.A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Mascitelli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Texas Health and Science Center, San Antonio (J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-3484","authenticated-orcid":true,"given":"Robert W.","family":"Regenhardt","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston (R.W.R., A. Alsarah)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-2728","authenticated-orcid":true,"given":"Stacey","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Wake Forest School of Medicine, Winston-Salem, NC (S.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-8774","authenticated-orcid":true,"given":"Mohamad","family":"Ezzeldin","sequence":"additional","affiliation":[{"name":"Neuroendovascular Surgery, HCA Houston Healthcare Kingwood, TX (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-7407","authenticated-orcid":true,"given":"Kaustubh","family":"Limaye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Indiana University, Bloomington (K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-6083","authenticated-orcid":true,"given":"Ramesh","family":"Grandhi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Utah, Salt Lake City (R.G., S.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-9789","authenticated-orcid":true,"given":"Hosam","family":"Al Jehani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, King Fahad Hospital of the University, Alkhobar, Saudi Arabia (H.A.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Niazi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wellspan Health, York, PA (M. 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