{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:06:21Z","timestamp":1790643981117,"version":"4.1.0"},"reference-count":78,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Currently, most acute ischemic stroke patients presenting with a large vessel occlusion are first evaluated at a nonthrombectomy-capable center before transfer to a comprehensive stroke center that performs thrombectomy. Interfacility transfer is a complex process that requires extensive coordination between the referring, transporting, and receiving facilities. As a result, long delays are common, contributing to poor clinical outcomes. In this review, we summarize the accumulating literature about the clinical as well as radiological\u2014infarct growth, collateral change, arterial recanalization, and hemorrhagic transformation\u2014changes during interfacility transfer for thrombectomy. Recent evidence shows that clinical\/radiological changes during transfer are heterogeneous across patients and impact long-term functional outcomes, highlighting the urgent need to optimize care during this time window. We review some of the most promising therapeutic strategies\u2014for example, penumbral protection to reduce infarct growth\u2014that may improve clinical outcome in patients being transferred to thrombectomy-capable centers. Finally, we discuss key methodological considerations for designing clinical trials aimed at reducing infarct growth during transfer.<\/jats:p>","DOI":"10.1161\/strokeaha.124.049167","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T10:01:57Z","timestamp":1730887317000},"page":"564-574","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Interfacility Transfer for Thrombectomy: A Promising Therapeutic Window"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-0691","authenticated-orcid":true,"given":"Pierre","family":"Seners","sequence":"first","affiliation":[{"name":"Neurology Department, Rothschild Foundation Hospital, Paris, France (P.S.)."},{"name":"Institut de Psychiatrie et Neurosciences de Paris, U1266, INSERM, France (P.S., J.-C.B.)."},{"name":"StrokeLink, French Clinical Research Infrastructure Network (F-CRIN), France (P.S., J.-P.D., F.P., R.M., J.-M.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-2588","authenticated-orcid":true,"given":"Jean-Claude","family":"Baron","sequence":"additional","affiliation":[{"name":"Institut de Psychiatrie et Neurosciences de Paris, U1266, INSERM, France (P.S., J.-C.B.)."},{"name":"INSERM U1266, Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Universit\u00e9 Paris Cit\u00e9, France (J.-C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-2699","authenticated-orcid":true,"given":"Anke","family":"Wouters","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Neurosciences, Experimental Neurology; 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