{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:11:39Z","timestamp":1765667499789,"version":"3.40.4"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The modified Rankin Scale (mRS) is a key measure of functional outcomes in stroke trials. To minimize variability, structured tools like the Rankin Focused Assessment and central adjudication are recommended. This study compares local versus centrally adjudicated mRS scores in the MOST trial (Multi-Arm Optimization of Stroke Thrombolysis).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>MOST was a phase 3, single-blind, randomized trial evaluating argatroban, eptifibatide, or placebo in addition to intravenous thrombolysis. The primary outcome, 90-day mRS score, was gathered through in-person video recordings by blinded local personnel. Recordings were sent to central adjudicators for final scoring. As in-person visits became limited due to SARS-CoV-2, remote interviews were allowed. We hypothesized that local mRS scores would be moderately associated with central scores. Fleiss-Cohen quadratic weighted \u03ba statistics were used to determine the strength of agreement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Out of 514 participants, 378 had recorded visits available (121 in-person video, 157 remote video, 100 remote audio). Local assessors were blinded 96.8% of the time and 85.4% of visits used the Rankin Focused Assessment. Overall agreement between local and central mRS scores was excellent (weighted \u03ba, 0.87 [95% CI, 0.83\u20130.90]). A nonsignificant decrease in strength of agreement was noted for those with a nonzero baseline mRS (mRS score=0, 0.87 [95% CI, 0.84\u20130.91] versus mRS score &gt;0, 0.80 [95% CI, 0.68\u20130.91]). Trial conclusions were unchanged when utilizing the local mRS versus central adjudication.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Local mRS scores demonstrated strong agreement with central scores across all assessment modes. With blinded end point assessments, central mRS adjudication in acute stroke trials may not be necessary.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03735979.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.124.049825","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T09:05:33Z","timestamp":1742807133000},"page":"1280-1284","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Local and Centrally Adjudicated Modified Rankin Scale Scores in the MOST Trial"],"prefix":"10.1161","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct03735979","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1605-6695","authenticated-orcid":true,"given":"Adham","family":"Shawkat","sequence":"first","affiliation":[{"name":"School of Medicine, University of Louisville, KY (A.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Science Center, Houston (A.D.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-7709","authenticated-orcid":true,"given":"Joseph P.","family":"Broderick","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (J.P.B., P.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-2683","authenticated-orcid":true,"given":"Colin P.","family":"Derdeyn","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Virginia, Charlottesville (C.P.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-4248","authenticated-orcid":true,"given":"James C.","family":"Grotta","sequence":"additional","affiliation":[{"name":"Clinical Institute for Research and Innovation, Memorial Hermann Hospital, Houston, TX (J.C.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-8266","authenticated-orcid":true,"given":"Pooja","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (J.P.B., P.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5263-7015","authenticated-orcid":true,"given":"Stephanie","family":"Pizzella","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Washington University, St. Louis, MO (S.P., O.M.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7604-3094","authenticated-orcid":true,"given":"Ian","family":"Rines","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina, Charleston (I.R., A.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-6156","authenticated-orcid":true,"given":"Akash","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina, Charleston (I.R., A.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair","family":"Wilson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (A.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-3951","authenticated-orcid":true,"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston (M.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-5369","authenticated-orcid":true,"given":"Opeolu M.","family":"Adeoye","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Washington University, St. Louis, MO (S.P., 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