{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:27Z","timestamp":1787018127873,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Diagnosing cerebral amyloid angiopathy (CAA) after spontaneous lobar intracerebral hemorrhage has significant clinical implications. A previous postmortem study found that the presence of both subarachnoid hemorrhage (SAH) and hematoma finger-like projections (FLP) on acute-stage computed tomography strongly rules in CAA. In the present study, we assessed the diagnostic value of these imaging markers against histopathologic diagnosis in less severe presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This retrospective (2002\u20132022) multicenter study included patients aged \u226545 years with lobar intracerebral hemorrhage of unknown cause, for whom acute-stage computed tomography or magnetic resonance imaging and neuropathological samples from hematoma evacuation or biopsy were available. Centralized consensus reading (2 raters) of imaging and neuropathological data (including A\u03b2 immunohistochemistry) were performed. Analysis was restricted to samples containing at least 10 vessels. The diagnostic performance was evaluated against the neuropathological reference, that is, CAA\/no CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We analyzed data from 66 patients (age, 65\u00b19 years; men, 33%; hematoma volume, 45\u00b126 mL; death within 1 year, 14%) from 6 French centers. Neuropathological material included samples from hematoma evacuation (n=48) and biopsy (n=18). CAA was present in 38 (58%) patients, and FLP and SAH were observed in 29 (44%) and 50 (76%) patients, respectively. FLP had a sensitivity of 0.58 (95% CI, 0.41\u20130.74) and a specificity of 0.74 (95% CI, 0.54\u20130.89) for the diagnosis of CAA. SAH demonstrated a high sensitivity of 0.92 (95% CI, 0.78\u20130.98; negative predictive value=0.80 [0.52\u20130.96]) but moderate specificity of 0.43 (95% CI, 0.24\u20130.63). The combined presence of FLP and SAH had a specificity of 0.54 (95% CI, 0.37\u20130.71) and a sensitivity of 0.79 (95% CI, 0.59\u20130.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This study is the first to evaluate the diagnostic performance of FLP and SAH with histopathologic reference in nonautopsied patients. The results suggest these markers have lower diagnostic performance than previously reported in severe hematomas leading to early death. However, the high sensitivity of SAH suggests its potential clinical utility in ruling out CAA when absent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.124.050159","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:01:17Z","timestamp":1745470877000},"page":"2190-2197","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Accuracy of Finger-Like Projections and Subarachnoid Hemorrhage for Cerebral Amyloid Angiopathy: Pathological Validation From Lobar Hematoma Evacuation or Brain Biopsy"],"prefix":"10.1161","volume":"56","author":[{"given":"Alexandra","family":"Maury","sequence":"first","affiliation":[{"name":"Department of Neurology (A.M., D.C., G.T., J.-C.B.), GHU Paris Psychiatrie et Neurosciences, Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (A.M., J.B., A.S., P.S., J.P., C.O., D.C., P.V., G.T., J.-C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0733-0104","authenticated-orcid":true,"given":"Joseph","family":"Benzakoun","sequence":"additional","affiliation":[{"name":"Department of Imaging (J.B., C.O.), GHU Paris Psychiatrie et Neurosciences, Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (A.M., J.B., A.S., P.S., J.P., C.O., D.C., P.V., G.T., J.-C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-2484","authenticated-orcid":true,"given":"Alexandre","family":"Bani-Sadr","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, CREATIS, CNRS UMR 5220, INSERM U 5220, Claude-Bernard Lyon I University, France (A.B.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-3351","authenticated-orcid":true,"given":"Adrien","family":"ter Schiphorst","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (A.M., J.B., A.S., P.S., J.P., C.O., D.C., P.V., G.T., J.-C.B.)."},{"name":"Department of Neurology, CHRU Gui de Chauliac, Montpellier, France (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Reiner","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP Nord, INSERM UMR-S 1144, FHU NeuroVasc, Paris, France (P.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Neurology, H. Mondor University Hospital, Cr\u00e9teil, France (H.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-0691","authenticated-orcid":true,"given":"Pierre","family":"Seners","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (A.M., J.B., A.S., P.S., J.P., C.O., D.C., P.V., G.T., J.-C.B.)."},{"name":"Department of Neurology, Rothschild Foundation Hospital, Paris, France (P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-9844","authenticated-orcid":true,"given":"Johan","family":"Pallud","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (J.P.), GHU Paris Psychiatrie et Neurosciences, Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France 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