{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:39:50Z","timestamp":1787445590155,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Bone marrow mononuclear cell (BM-MNC) intraarterial transplantation has emerged as a potential stroke therapy. We aimed to determine whether BM-MNC therapy induces changes in diffusion tensor imaging metrics of major white matter tracts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>The IBIS trial was an investigator-initiated multicenter, phase IIb, randomized, controlled, assessor-blinded, clinical trial. Seventy-seven patients (aged 18\u201380 years) with a nonlacunar middle cerebral artery ischemic stroke within 1 to 7 days from stroke onset and a National Institutes of Health Stroke Scale score of 6 to 20 were included. The primary outcome was the modified Rankin Scale score at 6 months. Among these participants, 38 patients (20 BM-MNCs-treated and 18 controls) had diffusion tensor imaging data available at both baseline and 6-month follow-up. Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity for white matter tracts were obtained. We determined the average changes in diffusion tensor imaging-metric values over the follow-up period and correlated corticospinal tract integrity with clinical outcomes using Spearman\u00b4s correlation coefficient.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The mean (SD) age was 60.7 (14.01) years; 22 (57.9%) were men, and 31 (81.6%) underwent thrombectomy. The median (interquartile range) National Institutes of Health Stroke Scale score before randomization was 12 (9\u201315). Baseline diffusion tensor imaging metrics were comparable between groups. Fractional anisotropy values of patients treated with BM-MNC decreased significantly less throughout corticospinal tract ipsilateral to stroke lesion (\u22120.05 [95% CI, \u22120.07 to \u22120.03] versus \u22120.06 [95% CI, \u22120.09 to \u22120.04];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001) and the body of corpus callosum (\u22120.03 [95% CI, \u22120.01 to \u22120.07] versus \u22120.04 [95% CI, \u22120.02 to 0.08];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001]. Better preservation of the ipsilateral corticospinal tract measured with fractional anisotropy was significantly correlated with clinical outcomes (ie, modified Rankin Scale score [\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =\u22120.478], National Institutes of Health Stroke Scale score [\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =\u22120.594], Barthel index [\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =0.466] at 6 months [all\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.01]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Intraarterial autologous BM-MNC transplantation within 7 days after stroke onset seems to modify long-term white matter tract microstructure, suggesting that this cell therapy may mitigate acute stroke damage, through main projection fibers. Greater corticospinal tract preservation was associated with improved clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02178657.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.124.050261","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T18:00:42Z","timestamp":1753725642000},"page":"2198-2209","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion Tensor Imaging Study After Intraarterial Cell Therapy in Acute Ischemic Stroke: A Substudy of the IBIS Randomized Clinical Trial"],"prefix":"10.1161","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct02178657","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-4643","authenticated-orcid":true,"given":"Juan Antonio","family":"Cabezas-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Neurology, Stroke Unit (J.A.C.-R., B.P.-G., L.A.-G., P.B.-P., M.M.-R., A.H., D.V., F.M.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Biarnes","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) and Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Spain (C.B., M.M.-N., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Mart\u00ed-Navas","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) and Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Spain (C.B., M.M.-N., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-0867","authenticated-orcid":true,"given":"V\u00edctor","family":"Pineda","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) and Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Spain (C.B., M.M.-N., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-0622","authenticated-orcid":true,"given":"Marc","family":"Comas-Cuf\u00ed","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Applied Mathematics and Statistics, University of Girona, Spain (M.C.-C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-5109","authenticated-orcid":true,"given":"Blanca","family":"Pardo-Galiana","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit (J.A.C.-R., B.P.-G., L.A.-G., P.B.-P., M.M.-R., A.H., D.V., F.M.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-1999","authenticated-orcid":true,"given":"Elena","family":"Zapata-Arriaza","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology (E.Z.-A., J.O.-Q., I.G., A.A.-C., M.A.-P., A.G.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-8257","authenticated-orcid":true,"given":"Pilar","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitario Virgen Del Roc\u00edo, Seville, Spain (P.P., R.O.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-2054","authenticated-orcid":true,"given":"Eduardo","family":"Aguera-Morales","sequence":"additional","affiliation":[{"name":"Department of Neurology, Reina Sof\u00eda University Hospital, Cordoba, Spain (E.A.-M., R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Valverde","sequence":"additional","affiliation":[{"name":"Department of Neurology, Reina Sof\u00eda University Hospital, Cordoba, Spain (E.A.-M., R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Ortega-Quintanilla","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology (E.Z.-A., J.O.-Q., I.G., A.A.-C., M.A.-P., A.G.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."},{"name":"Department of Interventional Neuroradiology, Hospital Universitario Son Espases, Mallorca, Spain (J.O.-Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-7052","authenticated-orcid":true,"given":"Leire","family":"Ainz-Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit (J.A.C.-R., B.P.-G., L.A.-G., P.B.-P., M.M.-R., A.H., D.V., F.M.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Baena-Palomino","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit (J.A.C.-R., B.P.-G., L.A.-G., P.B.-P., M.M.-R., A.H., D.V., F.M.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology (E.Z.-A., J.O.-Q., I.G., A.A.-C., M.A.-P., A.G.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-9586","authenticated-orcid":true,"given":"Manuel","family":"Medina-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit (J.A.C.-R., B.P.-G., L.A.-G., P.B.-P., M.M.-R., A.H., D.V., F.M.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ocete-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitario Virgen Del Roc\u00edo, Seville, Spain (P.P., R.O.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5167-1571","authenticated-orcid":true,"given":"Miguel Angel","family":"Gamero","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena\/CSIC\/Universidad de Sevilla, Seville, Spain (M.A.G., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-8534","authenticated-orcid":true,"given":"Asier","family":"de Alb\u00f3niga-Chindurza","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology (E.Z.-A., J.O.-Q., I.G., A.A.-C., M.A.-P., A.G.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Hermos\u00edn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit (J.A.C.-R., B.P.-G., L.A.-G., P.B.-P., M.M.-R., A.H., D.V., F.M.), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, 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