{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:49:53Z","timestamp":1781765393984,"version":"3.54.5"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Intracranial atherosclerotic disease (ICAD) is one of the leading causes of ischemic stroke worldwide. Despite advances in its diagnosis and management, there is no clear consensus on best practices to manage ICAD. This report summarizes the ARISE II (Roundtable Discussion With Industry and Stroke Experts) consensus in treating ICAD. The consensus underscored the importance of lifestyle modification and medical management in patients with ICAD. Patients who fail medical management are candidates for endovascular treatment. Open surgery is not recommended in patients who lack demonstrated hemodynamic insufficiency. The consensus also identified gaps in knowledge about the optimal duration of antithrombotics, the effect of the CYP2C19 genotype on medical management, the need for newer devices, and the standardization of antithrombotic protocols before stenting in an acute setting. Optical coherence tomography requires additional clinical data before defining its role in the diagnosis of ICAD.<\/jats:p>","DOI":"10.1161\/strokeaha.124.050336","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:01:02Z","timestamp":1748023262000},"page":"1636-1641","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["ARISE II Consensus on the Management of Intracranial Atherosclerotic Disease"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-9414","authenticated-orcid":true,"given":"Stavropoula I.","family":"Tjoumakaris","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA (S.I.T., J.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA (S.I.T., J.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1289-4596","authenticated-orcid":true,"given":"Sepideh","family":"Amin-Hanjani","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University Hospitals Cleveland Medical Center\/Case Western Reserve University School of Medicine, OH (S.A.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-2809","authenticated-orcid":true,"given":"Fady T.","family":"Charbel","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Illinois at Chicago (F.T.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-6035","authenticated-orcid":true,"given":"Guilherme","family":"Dabus","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology and Neuroendovascular Surgery, Miami Neuroscience Institute and Miami Cardiac and Vascular Institute-Baptist Hospital, FL (G.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-475X","authenticated-orcid":true,"given":"Marc","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (M.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8034-2785","authenticated-orcid":true,"given":"Matthew","family":"Gounis","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Chan Medical School, Worcester (M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4997-4469","authenticated-orcid":true,"given":"Brian L.","family":"Hoh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville (B.L.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-8736","authenticated-orcid":true,"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Los Angeles, LA (D.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-4294","authenticated-orcid":true,"given":"Italo","family":"Linfante","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology and Neuroendovascular Surgery, Miami Cardiac and Vascular Institute, Baptist Hospital of Miami, FL (I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-2268","authenticated-orcid":true,"given":"Edgar A.","family":"Samaniego","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Iowa Hospitals and Clinics (E.A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-3635","authenticated-orcid":true,"given":"Gabor","family":"Toth","sequence":"additional","affiliation":[{"name":"Cerebrovascular Center, Neurological Institute, Cleveland Clinic, OH (G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-4698","authenticated-orcid":true,"given":"Osama O.","family":"Zaidat","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Stroke Program, Bon Secours Mercy Health St Vincent Hospital, Toledo, OH (O.O.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-5237","authenticated-orcid":true,"given":"Pervinder","family":"Bhogal","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, The Royal London Hospital, Barts NHS Trust, United Kingdom (P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-1613","authenticated-orcid":true,"given":"Adam","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Tennessee Health Science Center, Memphis (A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-2107","authenticated-orcid":true,"given":"Ajay K.","family":"Wakhloo","sequence":"additional","affiliation":[{"name":"Department of Radiology, TUFTS University School of Medicine, Boston, MA (A.K.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ARISE II Academic Industry Roundtable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025732"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.578229"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.3772"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105254"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111749"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031611"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.038151"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01686-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1795132"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.063399"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.02.033"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.123157"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016835"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2024-022002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.045940"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020624"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adl4497"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz337"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jimed.2023.10.001"},{"key":"e_1_3_2_22_2","unstructured":"CeroFlo. Accessed April 25 2025. https:\/\/www.ceroflo.com\/"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-014-1001-3"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4804"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.570100"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020622"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4770"},{"key":"e_1_3_2_28_2","first-page":"53","article-title":"Development of gold stents for the treatment of intracranial aneurysms: an experimental study in a canine model.","volume":"25","author":"Ohyama T","year":"2004","unstructured":"Ohyama T, Nishide T, Iwata H, Taki W. Development of gold stents for the treatment of intracranial aneurysms: an experimental study in a canine model. AJNR Am J Neuroradiol. 2004;25:53\u201359.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00240.2011"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2109"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02556-z"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019844"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00387"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3171\/2024.4.jns24247"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020967256"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.124.050336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:01:23Z","timestamp":1748023283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.124.050336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1161\/STROKEAHA.124.050336"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.124.050336","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}