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Nonetheless, scalable digital health interventions, such as telestroke networks, mobile health platforms, artificial intelligence\u2013supported diagnostics, and telerehabilitation programs, have demonstrated efficacy and impact across diverse contexts. The central challenge has, thus, shifted from technological development to the systemic integration of these solutions within existing health infrastructures. Crucially, low- and middle-income countries must not be perceived solely as passive recipients of technology but as active agents of innovation, developing efficient, adaptive, and culturally attuned models prioritizing community engagement and a holistic conception of health. To realize the transformative potential of digital health, it is imperative to invest not only in technological infrastructure but also in promoting digital literacy, establishing robust ethical and regulatory frameworks, fostering cross-sectoral partnerships, and creating inclusive innovation ecosystems. Only through such a comprehensive, human-centered approach can digital health effectively serve as a catalyst for more equitable, resilient, and sustainable health systems, particularly for populations residing in resource-constrained settings.<\/jats:p>","DOI":"10.1161\/strokeaha.125.050448","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:00:16Z","timestamp":1756976416000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Digital Health in Low-Resource Settings: Comprehensive Challenges and Opportunities With a Focus on Stroke Care"],"prefix":"10.1161","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8768-7164","authenticated-orcid":true,"given":"Jo\u00e3o Brainer Clares","family":"de Andrade","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein, Academic Research Organization, S\u00e3o Paulo, Brazil (J.B.C.d.A., G.S.S.)."},{"name":"Department of Neurology, Department of Health Informatics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, Brazil (J.B.C.d.A., G.S.S.)."},{"name":"Aeronautics Institute of Technology, Bioengineering Laboratory, S\u00e3o Jos\u00e9 dos Campos, Brazil (J.B.C.d.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-9913","authenticated-orcid":true,"given":"Thales Pardini","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barretos Cancer Hospital, S\u00e3o Paulo, Brazil (T.P.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7538-4423","authenticated-orcid":true,"given":"Eric","family":"Katsuyama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculdade de Medicina do ABC, S\u00e3o Paulo, Brazil (E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-3123","authenticated-orcid":true,"given":"Gisele Sampaio","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Academic Research Organization, S\u00e3o Paulo, Brazil (J.B.C.d.A., G.S.S.)."},{"name":"Department of Neurology, Department of Health Informatics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, Brazil (J.B.C.d.A., G.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-02167-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2024.116570"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.036400"},{"key":"e_1_3_2_5_2","unstructured":"Global Burden of Disease Collaborative Network. 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