{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:21:43Z","timestamp":1792027303562,"version":"4.4.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Hematoma expansion (HE) is a preventable cause of disability and death in patients with acute intracerebral hemorrhage (ICH). Platelet activity is essential for coagulation, and antiplatelet medications (eg, aspirin, clopidogrel) increase HE risk. General markers of platelet activity are associated with later HE, but specific biomarkers of platelet activity could enhance our understanding. We hypothesized that hemostatic biomarkers of platelet activity would correlate with later HE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a tri-center observational cohort study of spontaneous ICH patients with multiple imaging scans for HE calculation. The thromboelastography 6s Platelet Mapping assay assessed platelet activity with 3 biomarkers: (1) adenosine diphosphate receptor-induced platelet activation, (2) platelet-fibrin network clot strength measured by heparinized kaolin with heparinase, and (3) fibrinogen-only clot strength measured by activator F (ActF). Spearman rank measured the correlation between HE and platelet activity. A linear regression model predicted HE from ActF. We tested whether the relationship between ActF and HE interacted with pre-ICH antiplatelet medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Thirty-five patients were included. Eleven (35.48%) took pre-ICH antiplatelet medication. Heparinized kaolin with heparinase negatively correlated with HE (\n                      <jats:italic toggle=\"yes\">\u03c1<\/jats:italic>\n                      =\u22120.34,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02), indicating that stronger platelet-fibrin clots were associated with less subsequent HE. ActF\u2019s association with HE depended on pre-ICH antiplatelet medication use (interaction\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.005). More ActF (fibrinogen) was associated with less HE in patients who did not take pre-ICH antiplatelet medication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Hemostatic biomarkers from the thromboelastography 6s Platelet Mapping assay predicted subsequent HE and may aid in determining neurosurgical need. Strengthening platelet-mediated coagulation may be a target for reducing HE and improving ICH outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.051447","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T09:00:46Z","timestamp":1752829246000},"page":"3084-3089","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Biomarkers of Thromboelastography Platelet Mapping Predict Hematoma Expansion After Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0906-7161","authenticated-orcid":true,"given":"Kaleigh M.","family":"Copenhaver","sequence":"first","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (K.M.C., J.S.P.N., A.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4460-666X","authenticated-orcid":true,"given":"Juliana","family":"Silva Pinheiro do Nascimiento","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (K.M.C., J.S.P.N., A.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1949-8019","authenticated-orcid":true,"given":"Rajeev K.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Division of Neurocritical Care, Rush University Medical Center, Chicago, IL (R.K.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-6830","authenticated-orcid":true,"given":"Fernando D.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Division of Neurocritical Care, Departments of Neurology and Neurosurgery, University of Chicago Medicine, IL (F.D.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Shownkeen","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Center, Northwestern Medicine-Central DuPage Hospital, Winfield, IL (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-5097","authenticated-orcid":true,"given":"Matthew B.","family":"Potts","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL (M.B.P., B.S.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-5278","authenticated-orcid":true,"given":"Babak S.","family":"Jahromi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL (M.B.P., B.S.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-6372","authenticated-orcid":true,"given":"Paul F.","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Feinberg School of Medicine, Chicago, IL (P.F.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-5417","authenticated-orcid":true,"given":"Andrew M.","family":"Naidech","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (K.M.C., J.S.P.N., A.M.N.)."},{"name":"Institute for Public Health and Medicine, Feinberg School of Medicine, Chicago, IL (A.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000138428.40673.83"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e3182143317"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21618"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.550939"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00110-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-009-9219-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52070"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38044"},{"key":"e_1_3_3_10_2","volume-title":"Thromboelastography","author":"Shaydakov ME","year":"2023","unstructured":"Shaydakov ME, Sigmon DF, Blebea J. 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StatPearls; 2023."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-021-03009-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.18999\/nagjms.82.4.623"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000133140.75831.1E"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108228"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2313040"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.125.051447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:01:17Z","timestamp":1758564077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.125.051447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1161\/STROKEAHA.125.051447"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.125.051447","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}