{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:29Z","timestamp":1787018129274,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute ischemic stroke, although clinical evidence remains conflicting. The TRICS BASIC study (Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke) investigated the efficacy and safety of RIC in experimental ischemic stroke using a rigorous clinical trial methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Multicenter, multispecies, parallel group, randomized, controlled, preclinical trial of transient femoral artery clipping to induce RIC in female and male rats and mice subjected to transient endovascular occlusion of the middle cerebral artery. Animals were randomized to receive RIC, or sham surgery, after reperfusion. The primary end point was a good functional outcome at 48 hours, assessed using a composite functional neuroscore. Secondary end points were infarct volume at 48 hours and safety, assessed using a standardized health report at 24 and 48 hours. Preenrollment harmonization, centralized monitoring, allocation concealment, blinded outcome assessment, and intention-to-treat analysis were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The trial enrolled 164 rodents (82 mice and 82 rats) of both sexes (53% females), across 7 laboratories. A greater proportion of RIC-treated rodents achieved a favorable functional outcome compared with controls, at 48 hours postischemia (55% versus 36%; odds ratio, 2.2 [95% CI, 1.23\u20134.4];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.009). RIC was associated with a small reduction in infarct volume (standardized mean difference, \u22120.38 [95% CI, \u22120.70 to \u22120.05];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.024). Health monitoring indicated no major safety concerns, and postoperative analgesia requirements were lower in RIC-treated mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Surgically induced RIC provided a modest but evident neuroprotective effect in experimental ischemic stroke, underscoring the potential of this strategy as an adjunctive treatment in stroke care. The findings of the TRICS BASIC study highlighted the importance of multicenter preclinical trials in addressing variability and enhancing translational validity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.preclinicaltrials.eu\">https:\/\/www.preclinicaltrials.eu<\/jats:ext-link>\n                      ; Unique identifier: PCTE0000177.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.051532","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T19:00:41Z","timestamp":1764010841000},"page":"3342-3351","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-2748","authenticated-orcid":true,"given":"Simone","family":"Beretta","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."},{"name":"Department of Neurology and Stroke Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy (S.B., S.D., C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-0887","authenticated-orcid":true,"given":"Mauro","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Dipartimento di Politiche per la Salute (M.T.), Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-1291","authenticated-orcid":true,"given":"Jacopo","family":"Mariani","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-1536","authenticated-orcid":true,"given":"Susanna","family":"Diamanti","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."},{"name":"Department of Neurology and Stroke Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy (S.B., S.D., C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-9278","authenticated-orcid":true,"given":"Alessia","family":"Valente","sequence":"additional","affiliation":[{"name":"Dipartimento di Danno Cerebrale e Cardiovascolare Acuto, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy (A. Valente, S.F., M.-G.D.S., C.P., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-2530","authenticated-orcid":true,"given":"Ornella","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, Italy (O.C., A. Vinciguerra, G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Universit\u00e0 della Calabria, Italy (C.D.S., D.A., G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Dettori","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-4683","authenticated-orcid":true,"given":"Martina","family":"Venturini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-4434","authenticated-orcid":true,"given":"Irene","family":"Bulli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-5919","authenticated-orcid":true,"given":"Elisabetta","family":"Coppi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Alejandro","family":"Montano Castillo","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."},{"name":"Department of Medicine and Surgery, Universit\u00e0 Vita-Salute San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-273X","authenticated-orcid":true,"given":"Erica","family":"Butti","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."},{"name":"Department of Medicine and Surgery, Universit\u00e0 Vita-Salute San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9580-6765","authenticated-orcid":true,"given":"Giorgia Serena","family":"Gullotta","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."},{"name":"Department of Medicine and Surgery, Universit\u00e0 Vita-Salute San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."},{"name":"Translational Neuropharmacology and Neuroscience Unit, Oasi Maria SS Onlus, Troina, Italy (G.S.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-6875","authenticated-orcid":true,"given":"Francesco","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7575-2569","authenticated-orcid":true,"given":"Francesco Andrea","family":"Pedrazzini","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."},{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-0003","authenticated-orcid":true,"given":"Carlo","family":"Perego","sequence":"additional","affiliation":[{"name":"Dipartimento di Danno Cerebrale e Cardiovascolare Acuto, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy (A. Valente, S.F., M.-G.D.S., C.P., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Seminara","sequence":"additional","affiliation":[{"name":"Dipartimento di Danno Cerebrale e Cardiovascolare Acuto, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy (A. Valente, S.F., M.-G.D.S., C.P., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenella","family":"Anzilotti","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Rome, Italy (S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-2794","authenticated-orcid":true,"given":"Joanna","family":"Rzemieniec","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Italy (J.R., L.C., B.M., M.M., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0772-3231","authenticated-orcid":true,"given":"Laura","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Italy (J.R., L.C., B.M., M.M., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0296-9194","authenticated-orcid":true,"given":"Benedetta","family":"Mercuriali","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Italy (J.R., L.C., B.M., M.M., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-442X","authenticated-orcid":true,"given":"Majeda","family":"Muluhie","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Italy (J.R., L.C., B.M., M.M., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1654-4996","authenticated-orcid":true,"given":"Chiara Paola","family":"Zoia","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Department of Medicine and Surgery (C.P.Z., G.S., C.F.), University of Milano-Bicocca, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-7523","authenticated-orcid":true,"given":"Gessica","family":"Sala","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Department of Medicine and Surgery (C.P.Z., G.S., C.F.), University of Milano-Bicocca, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-3454","authenticated-orcid":true,"given":"Luigi","family":"Sironi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Milano, Italy (J.R., L.C., B.M., M.M., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-2328","authenticated-orcid":true,"given":"Marco","family":"Bacigaluppi","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."},{"name":"Department of Medicine and Surgery, Universit\u00e0 Vita-Salute San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-9131","authenticated-orcid":true,"given":"Gianvito","family":"Martino","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."},{"name":"Department of Medicine and Surgery, Universit\u00e0 Vita-Salute San Raffaele, Milano, Italy (M.A.M.C., E.B., G.S.G., M.B., G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicita","family":"Pedata","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Italy (I.D., M. Venturini, I.B., E.C., F.P., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-3495","authenticated-orcid":true,"given":"Diana","family":"Amantea","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Universit\u00e0 della Calabria, Italy (C.D.S., D.A., G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-6218","authenticated-orcid":true,"given":"Giacinto","family":"Bagetta","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Universit\u00e0 della Calabria, Italy (C.D.S., D.A., G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, Italy (O.C., A. Vinciguerra, G.P.)."},{"name":"Dipartimento di Scienze Biomediche e Sanit\u00e0 Pubblica, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A. Vinciguerra)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7290-4397","authenticated-orcid":true,"given":"Giuseppe","family":"Pignataro","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, Italy (O.C., A. Vinciguerra, G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-6263","authenticated-orcid":true,"given":"Stefano","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Dipartimento di Danno Cerebrale e Cardiovascolare Acuto, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy (A. Valente, S.F., M.-G.D.S., C.P., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Grazia","family":"De Simoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Danno Cerebrale e Cardiovascolare Acuto, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy (A. Valente, S.F., M.-G.D.S., C.P., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-6600","authenticated-orcid":true,"given":"Carlo","family":"Ferrarese","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Stroke Research, Department of Medicine and Surgery, and Milan Center for Neuroscience (NeuroMI) (S.B., J.M., S.D., M. Vigan\u00f2, F.S., F.A.P., C.F.), University of Milano-Bicocca, Monza, Italy."},{"name":"Laboratory of Neurobiology, Department of Medicine and Surgery (C.P.Z., G.S., C.F.), University of Milano-Bicocca, Monza, Italy."},{"name":"Department of Neurology and Stroke Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy (S.B., S.D., C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(19)30034-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001258"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004075"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2009.00386.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040638"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0539-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0346"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164111X13007856084241"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.223"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20924077"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.02.008"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01836-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.16893"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13123"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221104710"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51063"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013572"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016429"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0326"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjos-2020-100063"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9853"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.01.002"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231159958"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17709185"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg8656"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017866"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-012-0209-2"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.125.051532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:31:05Z","timestamp":1781785865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.125.051532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1161\/STROKEAHA.125.051532"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.125.051532","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}