{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:11:03Z","timestamp":1781896263063,"version":"3.54.5"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      We aim to examine prospective associations of longitudinal adherence to antihypertensive medication,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carrier, and subsequent dementia risk in community-dwelling middle-aged and older adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A longitudinal cohort using 12-year survey data from wave 8 (2006) to wave 14 (2018) in the Health and Retirement Study, an ongoing national survey recruiting community-dwelling adults aged \u226550 years in the United States. Longitudinal adherence to antihypertensive medication was evaluated during wave 8 (2006) to wave 10 (2010), based on self-reported antihypertensive medication use at each wave. Incident dementia cases were ascertained during wave 10 (2010) to wave 14 (2018) by combining self-reported diagnosis and standardized cognitive batteries, excluding prevalent cases during the medication adherence evaluation period. Cox proportional hazard regression was utilized to assess dementia risk, with adjusted hazard ratios (HR) and 95% CIs calculated, controlling for sociodemographic characteristics, socioeconomic status indicators, lifestyle factors, and clinical conditions, as well as blood pressure measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 18\u2009469 participants were screened, after which 11\u2009835 participants (mean [SD] age: 66.2 [10.1] years; men: 40.6%) were included, with 1136 incident dementia cases. After controlling blood pressure and other known risk factors, hypertension participants who persistently adhered to antihypertensive medication during follow-up had a 27% lower dementia risk (HR, 0.73 [95% CI, 0.61\u20130.87]) than the low adherence group, which was more evident than the associations between baseline antihypertensive medication use and dementia. The difference in dementia risk was insignificant when comparing the high adherence group with the normotension group (HR, 1.03 [95% CI, 0.88\u20131.21]). The results were consistent in non-\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers (HR, 0.73 [95% CI, 0.59\u20130.89]) versus\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers (HR, 0.75 [95% CI, 0.55\u20131.02];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for interaction: 0.939).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Persistently adhering to antihypertensive medication was consistently associated with a lower subsequent dementia risk in community-dwelling middle-aged and older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.051564","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T10:00:27Z","timestamp":1766570427000},"page":"597-610","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Antihypertensive Medication Adherence,\n                    <i>APOE<\/i>\n                    Genotype, and Subsequent Dementia in Community-Dwelling Adults \u226550 Years"],"prefix":"10.1161","volume":"57","author":[{"given":"Yanan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition, Central Hospital, Tianjin University\/Tianjin Third Central Hospital, China (Y.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-3358","authenticated-orcid":true,"given":"Chenglong","family":"Li","sequence":"additional","affiliation":[{"name":"Medical School, Tianjin University, China (C.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_3_3_2","unstructured":"Alzheimer\u2019s Disease International. World Alzheimer Report 2023 Reducing dementia risk: never too early never too late. 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Health and Retirement Study. Accessed June 19 2025. https:\/\/www.nia.nih.gov\/research\/resource\/health-and-retirement-study-hrs"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu067"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01467-y"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285122"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182984c1f"},{"key":"e_1_3_3_19_2","unstructured":"Faul J Collins S Smith J Zhao W Kardia S Weir D. Health and Retirement Study: APOE and serotonin transporter alleles\u2014early release. 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