{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:46Z","timestamp":1792787626478,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Route 92"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Rapid and complete recanalization is a primary goal in the endovascular treatment of large vessel occlusion stroke. The effectiveness and safety of super large bore aspiration catheters (0.088\u2033 inner diameter) for the treatment of large vessel occlusion stroke have not been demonstrated in a randomized trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>SUMMIT MAX (A Prospective, Randomized, Controlled, Interventional Clinical Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical MonoPoint Reperfusion System for Aspiration Embolectomy in Acute Ischemic Stroke Patients) was a prospective, randomized, controlled, open-label clinical trial of patients with internal carotid artery and middle cerebral artery M1 occlusions, comparing the super large bore HiPoint Reperfusion system (Route 92 Medical) to the Vecta Aspiration system (Stryker Neurovascular). We hypothesized that the effectiveness and safety of the HiPoint reperfusion system were noninferior (12.5% noninferiority margin) to the Vecta Aspiration system. The primary effectiveness end point was successful reperfusion, defined as modified Treatment in Cerebral Infarction\u22652b as adjudicated by an independent core lab, using only the assigned study device, with any use of a nonstudy device before or after the use of study device defined as failure. The primary safety end point was symptomatic intracranial hemorrhage within 24 hours (\u22128\/+24) post-procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There were 250 patients enrolled of whom 166 met the criteria for the modified intent-to-treat population: 89 in HiPoint and 77 in Vecta. The median age was 69 years; 54.2% were female. Successful reperfusion with any adjunctive therapy counted as a failure was 77.5% (69\/89) in the HiPoint group versus 50.6% (39\/77) in the Vecta group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001 for noninferiority). Symptomatic intracranial hemorrhage within 24 hours (\u22128\/+24 hours) post-procedure was similar between groups (3.6% versus 2.7%, respectively). At 90 days, good clinical outcome (mRS score of \u22642) was achieved in 50.6% in the HiPoint group and 53.3% in the Vecta group (absolute difference, \u22122.8% [95% CI, \u221218.2% to 12.7%];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In this randomized trial of patients with anterior large vessel occlusion, the super large bore HiPoint system was noninferior to the Vecta system in achieving successful reperfusion, with a similar safety profile. This study supports the super large bore HiPoint system for mechanical thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT05018650.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.051742","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T03:23:42Z","timestamp":1747797822000},"page":"1980-1990","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["SUMMIT MAX: A Randomized Trial of the Super Large Bore HiPoint Reperfusion System Versus Vecta System for Aspiration Thrombectomy"],"prefix":"10.1161","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct05018650","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-1685","authenticated-orcid":true,"given":"Thanh N.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Neurology, Radiology, Boston Medical Center, MA (T.N.N., M. Abdalkader, R.A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-6035","authenticated-orcid":true,"given":"Guilherme","family":"Dabus","sequence":"additional","affiliation":[{"name":"Miami Neuroscience Institute and Miami Cardiac &amp; Vascular Institute, Baptist Health South Florida (G.D., I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"McGuinness","sequence":"additional","affiliation":[{"name":"Auckland City Hospital, New Zealand (B.M., J.C., S.L., M.J.P., D.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-9901","authenticated-orcid":true,"given":"James","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Auckland City Hospital, New Zealand (B.M., J.C., S.L., M.J.P., D.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-3783","authenticated-orcid":true,"given":"Ryan","family":"Priest","sequence":"additional","affiliation":[{"name":"Dotter Interventional Institute, Oregon Health &amp; Science University, Portland (R.P., M.C., J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-4805","authenticated-orcid":true,"given":"Ansaar T.","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown (A.T.R., S.B., P.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-4698","authenticated-orcid":true,"given":"Osama O.","family":"Zaidat","sequence":"additional","affiliation":[{"name":"Mercy Health St. Vincent Medical Center, Toledo, OH (O.O.Z., E.L., M. Almajali)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6999-7967","authenticated-orcid":true,"given":"Bradley A.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pittsburgh Medical Center, PA (B.A.G., A.A.-B., M.J.L., R.G.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7195-5806","authenticated-orcid":true,"given":"Ricardo","family":"Hanel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Baptist Health Jacksonville, FL (R.H., A.A., E.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-9331","authenticated-orcid":true,"given":"Shane","family":"Lee","sequence":"additional","affiliation":[{"name":"Auckland City Hospital, New Zealand (B.M., J.C., S.L., M.J.P., D.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazam","family":"Hussain","sequence":"additional","affiliation":[{"name":"Cerebrovascular Center, Cleveland Clinic, OH (S.H., M.B., G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-4600","authenticated-orcid":true,"given":"Hamza","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute, Cooper University Hospital, Camden, NJ (H.S., D.A.T., J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-301X","authenticated-orcid":true,"given":"Mohamad","family":"Abdalkader","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology, Boston Medical Center, MA (T.N.N., M. 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