{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:36:02Z","timestamp":1790256962338,"version":"4.1.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Poststroke depression affects up to one-third of stroke survivors, significantly impacting recovery and quality of life. However, its pathophysiology remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We analyzed 2 independent, prospective ischemic stroke cohorts (PROSCIS-B [Prospective Cohort of Incident Stroke Berlin] and BAPTISe [Biomarkers and Perfusion-Training-Induced Changes After Stroke]; n=377) enrolled at the Charit\u00e9 Hospital, Germany, to identify brain regions and networks associated with depressive symptoms poststroke. Lesion-symptom mapping assessed associations between lesion location and depressive symptoms measured by the Center for Epidemiological Studies Depression Scale at 6 (BAPTISe) or 12 (PROSCIS-B) months poststroke. Lesion-network mapping evaluated lesion connectivity with brain networks. A mixed-effects model, including cohort as a random effect, assessed the relationship between network similarity (Pearson correlation) and Center for Epidemiological Studies Depression Scale scores. Dice coefficients (DC) quantified spatial overlap with canonical resting-state networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Lesion-symptom mapping showed no significant associations between lesion location and depressive symptoms. In contrast, lesion-network mapping revealed that lesion connectivity to brain regions including the frontal pole, middle and inferior frontal gyri, inferior temporal gyrus, supramarginal gyrus, angular gyrus, frontal orbital cortex, and thalamus weakly correlated with Center for Epidemiological Studies Depression Scale scores (\u03b2, 11.4 [95%CI, 1.8\u201321.1];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02). These regions overlapped with the frontoparietal (DC=0.28), salience (DC=0.27), and default mode (DC=0.20) networks, as well as a published depression circuit (DC=0.43). However, these findings did not replicate across data sets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Lesion location alone was not associated with poststroke depression. However, connectivity-based analyses implicated disruption of large-scale brain networks in the development of depressive symptoms. The failure to validate this association across data sets underscores the need for further studies with more comparable patient populations\u2014particularly in terms of stroke severity and harmonized assessment time-points\u2014to confirm these findings and their clinical relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT01363856. URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT01954797.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.051858","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T05:00:13Z","timestamp":1751864413000},"page":"2527-2539","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Lesion-Network Mapping of Poststroke Depressive Symptoms: Evidence From Two Prospective Ischemic Stroke Cohorts"],"prefix":"10.1161","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct01363856","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01954797","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3680-8680","authenticated-orcid":true,"given":"Ana Sof\u00eda","family":"R\u00edos","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchralt","family":"Temuulen","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-4305","authenticated-orcid":true,"given":"Ahmed A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-9193","authenticated-orcid":true,"given":"Kersten","family":"Villringer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0322-5291","authenticated-orcid":true,"given":"Huma Fatima","family":"Ali","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."},{"name":"International Graduate Program Medical Neurosciences at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany (H.F.A.)."},{"name":"Einstein Center for Neurosciences (ECN) Berlin, Germany (H.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-0224","authenticated-orcid":true,"given":"Ulrike","family":"Grittner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Institut f\u00fcr Biometrie und klinische Epidemiologie, Germany (U.G., M.B.)."},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany (U.G., C.O., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1267-8854","authenticated-orcid":true,"given":"Matthias","family":"Becher","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Institut f\u00fcr Biometrie und klinische Epidemiologie, Germany (U.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-5803","authenticated-orcid":true,"given":"Torsten","family":"Rackoll","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."},{"name":"Berlin Institute of Health at Charit\u00e9 Universit\u00e4tsmedizin Berlin, QUEST Center for Responsible Research, Germany (T.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-4557","authenticated-orcid":true,"given":"Alexander Heinrich","family":"Nave","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."},{"name":"German Center for Cardiovascular Research (Deutsches Zentrum f\u00fcr Herz Kreislauferkrankungen, DZHK), Berlin, Germany (A.H.N., M.E.)."},{"name":"German Center for Neurodegenerative Diseases (Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen, DZNE), Berlin, Germany (A.H.N., M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-2374","authenticated-orcid":true,"given":"Pia S.","family":"Sperber","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."},{"name":"Experimental and Clinical Research Center, a Cooperation between the Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association and the Charit\u00e9-Universit\u00e4tsmedizin Berlin, Germany (P.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-8049","authenticated-orcid":true,"given":"Thomas G.","family":"Liman","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-997X","authenticated-orcid":true,"given":"Christian","family":"Otte","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany (U.G., C.O., A.K.)."},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Germany (C.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-3720","authenticated-orcid":true,"given":"Matthias","family":"Endres","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."},{"name":"German Center for Cardiovascular Research (Deutsches Zentrum f\u00fcr Herz Kreislauferkrankungen, DZHK), Berlin, Germany (A.H.N., M.E.)."},{"name":"German Center for Neurodegenerative Diseases (Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen, DZNE), Berlin, Germany (A.H.N., M.E.)."},{"name":"German Center for Mental Health (Deutsches Zentrum f\u00fcr Psychische Gesundheit, DZPG), Berlin, Germany (M.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-313X","authenticated-orcid":true,"given":"Anna","family":"Kufner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie mit Experimenteller Neurologie Germany (A.S.R., U.T., A.A.K., K.V., M.B., T.R., A.H.N., P.S.S., T.G.L., C.O., M.E., A.K.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Center for Stroke Research Berlin (CSB) Germany (A.S.R., U.T., A.A.K., K.V., H.F.A., T.R., A.H.N., P.S.S., T.G.L., M.E., A.K.)."},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany (U.G., C.O., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12357"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12356"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2020.06.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-017-9356-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003689.pub4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000113"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714527514"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.01.019"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15030363"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23490"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706158"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00060-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1144228"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac361"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.2.283"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1993.11740164"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI136096"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1100067"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.07.023"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-021-01161-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-022-00002-y"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad275"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00218"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.01.003"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00871.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-197"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854040802691135"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537606"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1037\/\/0882-7974.12.2.277"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_3_3_33_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-642-04898-2_110","volume-title":"International Encyclopedia of Statistical Science","author":"Akaike H","year":"2011","unstructured":"Akaike H. Akaike\u2019s information criterion. In: Lovric M, ed. International Encyclopedia of Statistical Science. Springer Berlin Heidelberg; 2011:25\u201325."},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.06.013"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1053-8119(09)70884-5"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2015.31"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24974"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.119862"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24289"},{"key":"e_1_3_3_42_2","volume-title":"Permutation Tests: A Practical Guide to Resampling Methods for Testing Hypotheses","author":"Good P","year":"2013","unstructured":"Good P. Permutation Tests: A Practical Guide to Resampling Methods for Testing Hypotheses. 3 ed. Springer Science & Business Media; 2013","edition":"3"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.045"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.03.015"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.24.1.35"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.100209"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731958"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000162391.27991.9d"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.679340"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2013-1939"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.2\/smarek"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.052"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1133367"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014030"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.003"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.125.051858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:28:51Z","timestamp":1786631331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.125.051858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1161\/STROKEAHA.125.051858"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.125.051858","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}