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Low-intensity focused ultrasound stimulation has emerged as a noninvasive neuromodulatory approach with promising potential for modulating poststroke immune responses and promoting neuroprotection. Low-intensity focused ultrasound stimulation can enhance stroke recovery by modulating immune cell activity and alleviating neuroinflammation. This review explores the multifaceted interplay between low-intensity focused ultrasound stimulation and the immune response in stroke, examining how ultrasound parameters can be optimized to achieve anti-inflammatory effects. 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