{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:55:57Z","timestamp":1787795757768,"version":"build-2784847793"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Novel stroke risk factors have received widespread attention. This study examined the association between sarcopenia status, grip strength, and walking pace with incident stroke (any stroke, ischemic stroke, and hemorrhagic stroke) and poststroke mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This prospective study included 482\u2009699 participants from the UK Biobank, a large-scale, population-based cohort. Sarcopenia status was assessed according to the EWGSOP2 criteria (European Working Group on Sarcopenia in Older People 2). Incident strokes were ascertained based on health records. Stroke risk was assessed using multivariable-adjusted Cox proportional hazards models, whereas poststroke mortality was compared using the Kaplan-Meier analysis with log-rank tests. A 2-sample Mendelian randomization analysis, utilizing genetic instruments from public genome-wide association studies, was conducted to infer causal associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The cohort (mean age\u00b1SD: 56.4\u00b18.1 years; 45.37% were men; n=219\u2009015) had a probable sarcopenia prevalence of 4.7% and a confirmed sarcopenia prevalence of 0.4%. Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21\u22121.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22\u22121.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20\u22121.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06\u22121.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28\u22121.44] per 1 kg\/[kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ]) and a slow walking pace (aHR, 1.64 [95% CI, 1.54\u22121.75]; compared with brisk pace). Mendelian randomization analysis demonstrated that a faster walking pace was associated with a lower risk of any stroke (odds ratio, 0.94 [95% CI, 0.90\u22120.97] per-SD increase) and ischemic stroke (odds ratio, 0.95 [95% CI, 0.91\u22120.98] per-SD increase).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Sarcopenia status, lower grip strength, and slower walking pace were associated with an increased risk of incident stroke and all-cause poststroke mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.052311","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:11:47Z","timestamp":1778253107000},"page":"1574-1585","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Sarcopenia, Grip Strength, Walking Pace, and New-Onset Stroke Risk: A UK Biobank Study"],"prefix":"10.1161","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4850-3698","authenticated-orcid":true,"given":"Li-Li","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (Y.-H.H., C.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7876-6028","authenticated-orcid":true,"given":"Yu-Jia","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8711-2882","authenticated-orcid":true,"given":"Kai-Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5248-2236","authenticated-orcid":true,"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou First People\u2019s Hospital, China (Q.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-7113","authenticated-orcid":true,"given":"Zien","family":"Zhou","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (Z.Z.)."},{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (Z.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-2763","authenticated-orcid":true,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-3388","authenticated-orcid":true,"given":"Bing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (B.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (Y.-H.H., C.Y.)."},{"name":"Department of Nutrition, Harvard T.H. 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