{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:39:49Z","timestamp":1787445589222,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Endothelial progenitor cells (EPCs) contribute to vascular repair and may play a critical role in recovery following cerebrovascular disease. This study aimed to evaluate the association between circulating EPC levels and clinical outcomes in patients with ischemic stroke, hemorrhagic stroke, and transient ischemic attack.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a prospective observational study at Hospital Universitario de Gran Canaria Doctor Negr\u00edn (Spain) between September 2023 and June 2024. We evaluated the association between circulating EPC levels and clinical outcomes in 126 patients with cerebrovascular disease (mean age, 70.4\u00b112.9 years; 58.7% male), recruited within 48 hours of symptom onset. EPCs were quantified at admission (&lt;48 hours), day 7, and 12 weeks. The primary outcome was favorable functional status at 3 months (modified Rankin Scale score, 0\u20132). Secondary outcomes included stroke severity (National Institutes of Health Stroke Scale), hospital stay, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Higher EPC levels on day 7 were independently associated with favorable functional outcome at 3 months (odds ratio, 0.769 [95% CI, 0.605\u20130.977];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.032). Significant negative correlations were found between EPCs at day 7 and stroke severity at admission (r=\u20130.205;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.034) and length of hospital stay (r=\u20130.253;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.008). EPCs at day 7 were significantly lower in patients who died during follow-up (mean rank, 44.40 versus 56.34;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004). Subgroup analysis in patients with ischemic stroke confirmed that day-7 EPC levels remained an independent predictor of good outcome (odds ratio, 0.743 [95% CI, 0.570\u20130.968];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.028), shorter hospitalization (r=\u20130.278;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.006), and survival (U=552.000;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>EPC levels at day 7 may serve as a prognostic biomarker for recovery and mortality in cerebrovascular disease. These findings suggest a potential therapeutic window targeting endothelial repair mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.052464","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:00:13Z","timestamp":1754470813000},"page":"2914-2927","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of Endothelial Progenitor Cells on Outcomes in Cerebrovascular Disease"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-7069","authenticated-orcid":true,"given":"Juan Francisco","family":"Garc\u00eda Granado","sequence":"first","affiliation":[{"name":"Universidad de Las Palmas de Gran Canaria, Spain (J.F.G.G., F.J.R.E.)."},{"name":"Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain (J.F.G.G., A.N.G.H., F.J.R.E., J.M.G.M., S.E.C.R., A.R.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-3603","authenticated-orcid":true,"given":"Ayoze Nauzet","family":"Gonz\u00e1lez Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain (J.F.G.G., A.N.G.H., F.J.R.E., J.M.G.M., S.E.C.R., A.R.U.)."},{"name":"Universidad Fernando Pessoa Canarias, Las Palmas, Spain (A.N.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-3673","authenticated-orcid":true,"given":"Francisco Javier","family":"Rodr\u00edguez Esparrag\u00f3n","sequence":"additional","affiliation":[{"name":"Universidad de Las Palmas de Gran Canaria, Spain (J.F.G.G., F.J.R.E.)."},{"name":"Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain (J.F.G.G., A.N.G.H., F.J.R.E., J.M.G.M., S.E.C.R., A.R.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-4157","authenticated-orcid":true,"given":"Jes\u00fas Mar\u00eda","family":"Gonz\u00e1lez Mart\u00edn","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain (J.F.G.G., A.N.G.H., F.J.R.E., J.M.G.M., S.E.C.R., A.R.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-7807","authenticated-orcid":true,"given":"Sara Estefan\u00eda","family":"Cazorla Rivero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain (J.F.G.G., A.N.G.H., F.J.R.E., J.M.G.M., S.E.C.R., A.R.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Raposo Usero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain (J.F.G.G., A.N.G.H., F.J.R.E., J.M.G.M., S.E.C.R., A.R.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0212-8241(08)72472-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337155"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-702"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000073832.49290.B5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1889-1837(03)71382-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22627"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000250175.14861.77"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.05.008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016677982"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0362-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.489401"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.178"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.125.052464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:00:52Z","timestamp":1758564052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.125.052464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1161\/STROKEAHA.125.052464"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.125.052464","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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