{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:58:58Z","timestamp":1785178738821,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Patients surviving spontaneous intracerebral hemorrhage (ICH) who have indications for antithrombotic treatment face increased risks of both hemorrhagic and ischemic events. The aim of STATICH (Study of Antithrombotic Treatment After Intracerebral Haemorrhage) was to assess the safety and efficacy of long-term antithrombotic treatment after ICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>STATICH Antiplatelets (EudraCT 2014-002636-13; Unique identifier: NCT03186729) was a randomized, multicenter, open, blinded end point parallel-group trial, including adults with an indication for antiplatelet treatment to either start or avoid antiplatelet treatment. The target sample size was 500 participants. Patients were allocated 1:1 by a Web-based randomization system and followed for a minimum of 2 years. Outcome assessments were done by personnel blinded to treatment. Participants were not blinded. The primary safety outcome was recurrent symptomatic ICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The trial was stopped early due to slow recruitment. Sixty-nine patients were included between August 2018 and December 2022: 34 were randomized to start antiplatelet treatment, and 35 were randomized to avoid antiplatelet treatment. No patients were excluded from analyses. The median age was 75 (Q1\u2013Q3, 66\u201380) years, and 43 (75%) had previous ischemic stroke or transient ischemic attack. Five patients in the start antiplatelet treatment group (15% [95% CI, 6%\u201331%]), and 1 in the avoid group (3% [95% CI, 0%\u201318%]) experienced recurrent ICH, while 3 (9% [95% CI, 3%\u201324%]) and 7 (20% [95% CI, 10%\u201337%]), respectively, experienced a major ischemic event. A total of 88 serious adverse events and no suspected unexpected serious adverse reactions were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>There were numerically more recurrent ICHs and fewer ischemic events in patients starting antiplatelet treatment after ICH compared with those avoiding antiplatelet treatment. The slow recruitment might be due to clinicians being certain of the best treatment strategy or patients being too frail to participate. STATICH will contribute to a planned collaborative individual patient-data meta-analysis to resolve this dilemma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.054990","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:01:39Z","timestamp":1781773299000},"page":"2287-2294","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Study of Antithrombotic Treatment After Intracerebral Haemorrhage-Antiplatelets: A Randomized Trial"],"prefix":"10.1161","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3369-2711","authenticated-orcid":true,"given":"Helle","family":"Eilertsen","sequence":"first","affiliation":[{"name":"Oslo University Hospital, Norway (H.E., K.T.L., E.F., Hege Ihle-Hansen, T.B.W., E.C.S.)."},{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-8243","authenticated-orcid":true,"given":"Kristin Tveitan","family":"Larsen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Norway (H.E., K.T.L., E.F., Hege Ihle-Hansen, T.B.W., E.C.S.)."},{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."},{"name":"Akershus University Hospital, L\u00f8renskog, Norway (K.T.L., T.L.-H., O.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Forfang","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Norway (H.E., K.T.L., E.F., Hege Ihle-Hansen, T.B.W., E.C.S.)."},{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-4690","authenticated-orcid":true,"given":"Johanna","family":"Pennlert","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Ume\u00e5 University, Sweden (J.P., E.-L.G., P.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-6501","authenticated-orcid":true,"given":"Eva-Lotta","family":"Glader","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Ume\u00e5 University, Sweden (J.P., E.-L.G., P.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-0523","authenticated-orcid":true,"given":"Christina","family":"Kruuse","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev and Gentofte, Denmark (C.K.)."},{"name":"Department of Brain and Spinal Cord Injury, Neuroscience Center, Rigshospitalet, Copenhagen, Denmark (C.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-5096","authenticated-orcid":true,"given":"Per","family":"Wester","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Ume\u00e5 University, Sweden (J.P., E.-L.G., P.W.)."},{"name":"Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (P.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-9799","authenticated-orcid":true,"given":"Hege","family":"Ihle-Hansen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Norway (H.E., K.T.L., E.F., Hege Ihle-Hansen, T.B.W., E.C.S.)."},{"name":"Institute of Health and Society (Hege Ihle-Hansen), University of Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-7849","authenticated-orcid":true,"given":"Maria","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, UiT The Arctic University of Norway, Troms\u00f8 (M.C.)."},{"name":"Nordland Hospital Trust, Bod\u00f8, Norway (M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8708-8150","authenticated-orcid":true,"given":"Trine","family":"Lied-Herland","sequence":"additional","affiliation":[{"name":"Akershus University Hospital, L\u00f8renskog, Norway (K.T.L., T.L.-H., O.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-2272","authenticated-orcid":true,"given":"J\u016brat\u0117 \u0160altyt\u0117","family":"Benth","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."},{"name":"Health Services Research Unit, Akershus University Hospital, L\u00f8renskog, Norway (J.S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-5970","authenticated-orcid":true,"given":"H\u00e5kon","family":"Ihle-Hansen","sequence":"additional","affiliation":[{"name":"Medical Department, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway (H\u00e5kon Ihle-Hansen)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-9033","authenticated-orcid":true,"given":"Yngve","family":"Seljeseth","sequence":"additional","affiliation":[{"name":"Moere and Romsdal Health Trust, \u00c5alesund Hospital, Norway (Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-8357","authenticated-orcid":true,"given":"Marie Norsker","family":"Folke","sequence":"additional","affiliation":[{"name":"Bispebjerg Frederiksberg Hospital, Copenhagen, Denmark (M.N.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-9222","authenticated-orcid":true,"given":"Rustam","family":"Al-Shahi Salman","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, United Kingdom (R.A.-S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgeir Bruun","family":"Wyller","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Norway (H.E., K.T.L., E.F., Hege Ihle-Hansen, T.B.W., E.C.S.)."},{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5788","authenticated-orcid":true,"given":"Ole Morten","family":"Ronning","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."},{"name":"Akershus University Hospital, L\u00f8renskog, Norway (K.T.L., T.L.-H., O.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-4778","authenticated-orcid":true,"given":"Else Charlotte","family":"Sandset","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Norway (H.E., K.T.L., E.F., Hege Ihle-Hansen, T.B.W., E.C.S.)."},{"name":"Institute of Clinical Medicine (H.E., K.T.L., E.F., J.S.B., T.B.W., O.M.R., E.C.S.), University of Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of all STATICH Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037633"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0925"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00075-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306476"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018789996"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-81526-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8380"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f735e5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30840-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.4347"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987320954671"},{"key":"e_1_3_3_14_2","volume-title":"Guideline for good clinical practice E6(R2) European Medicine Agency website","year":"2016","unstructured":"Guideline for good clinical practice E6(R2) European Medicine Agency website. 2016. Accessed October 9, 2025. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-guideline-good-clinical-practice-e6r2-step-5-revision-2_en.pdf"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7495.843"},{"key":"e_1_3_3_16_2","volume-title":"Statistical software: release 18","author":"StataCorp","year":"2025","unstructured":"StataCorp. Statistical software: release 18. StataCorp LLC. 2025."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000131547.71502.81"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103880"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1909-4"},{"key":"e_1_3_3_20_2","volume-title":"The effects of long-term oral antithrombotic agents after intracranial haemorrhage: prospective individual participant data meta-analysis (IPDMA) of randomised controlled trials","author":"Al-Shahi S","year":"2024","unstructured":"Al-Shahi S. The effects of long-term oral antithrombotic agents after intracranial haemorrhage: prospective individual participant data meta-analysis (IPDMA) of randomised controlled trials. 2024. Accessed May 30, 2025. https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42021246133"},{"key":"e_1_3_3_21_2","volume-title":"The use of aspirin or clopidogrel for people who survive stroke due to bleeding in the brain","unstructured":"The use of aspirin or clopidogrel for people who survive stroke due to bleeding in the brain. Accessed May 25, 2025. https:\/\/www.isrctn.com\/ISRCTN16705062"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.125.054990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:01:38Z","timestamp":1785175298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.125.054990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1161\/STROKEAHA.125.054990"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.125.054990","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}