{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:38:29Z","timestamp":1786113509967,"version":"build-2736575974"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 receptor agonists reduce major adverse cardiovascular events in type 2 diabetes. Although body mass index does not seem to modify these effects, whether insulin resistance influences treatment efficacy remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This post hoc analysis of the LAMP trial (Liraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack Patients With Type 2 Diabetes Mellitus; a multicenter, open-label, randomized controlled trial conducted at 27 hospitals in China between June 25, 2019, and December 27, 2023) included patients with minor ischemic stroke or high-risk transient ischemic attack and type 2 diabetes. Participants were randomized (1:1) to liraglutide plus standard therapy or standard therapy alone. IR was assessed using the homeostasis model assessment of IR, with a cutoff of 2.5 based on prior studies in Asian populations. Treatment-by-IR interactions were evaluated using Cox models. Absolute risk reduction was calculated as the difference in event rates between groups and was based on crude estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 636 enrolled patients, 510 were included in this analysis (mean age, 65 years; 64.7% male; follow-up, 3 months). A significant interaction between treatment and insulin resistance was observed for both stroke recurrence and composite vascular events (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for interaction=0.02 for both). Among patients with homeostasis model assessment of IR \u22652.5, liraglutide reduced stroke recurrence (5.8% versus 18.1%; absolute risk reduction, 12.3% [95% CI, 5.6%\u201319.0%]; number needed to treat=8) and vascular events (5.8% versus 19.2%; absolute risk reduction, 13.4% [95% CI, 6.6%\u201320.2%]; number needed to treat=8). No significant benefit was observed in those with homeostasis model assessment of IR &lt;2.5.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>IR may be an important determinant of the therapeutic efficacy of liraglutide in patients with acute minor ischemic stroke or high-risk transient ischemic attack and type 2 diabetes. IR-based stratification may help optimize the use of glucagon-like peptide-1 receptor agonists in secondary stroke prevention and guide personalized vascular risk management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03948347.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.125.056010","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:00:39Z","timestamp":1779094839000},"page":"1960-1970","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Liraglutide and Recurrent Stroke by Baseline Insulin Resistance: A Post Hoc Analysis of the LAMP Trial"],"prefix":"10.1161","volume":"57","clinical-trial-number":[{"clinical-trial-number":"nct03948347","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2466-799X","authenticated-orcid":true,"given":"Longyan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-8163","authenticated-orcid":true,"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8327-4390","authenticated-orcid":true,"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."},{"name":"Department of Neurology, Guangdong Sanjiu Brain Hospital, Guangzhou, China (Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."},{"name":"Department of Neurology, the First People\u2019s Hospital of Zhaoqing, China (F.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4124-0954","authenticated-orcid":true,"given":"Yanfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-8452","authenticated-orcid":true,"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-7532","authenticated-orcid":true,"given":"Li\u2019an","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-0985","authenticated-orcid":true,"given":"Anding","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-8671","authenticated-orcid":true,"given":"Huili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute, Jinan University, Guangzhou, China (L.L., B.Y., Y.W., C.Z., Z.L., F.L., S.Y., Y.L., Y.Y., X.L., L.H., A.X., H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12591"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2025.5684"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31149-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00203-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn4128"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.14392"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0919"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231164548"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30405-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506930"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0356"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3145-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017694391"},{"key":"e_1_3_3_17_2","first-page":"4","article-title":"Chinese guideline for the prevention and treatment of type 2 diabetes mellitus (2017 edition).","volume":"10","author":"Chinese Diabetes Society","year":"2018","unstructured":"Chinese Diabetes Society. Chinese guideline for the prevention and treatment of type 2 diabetes mellitus (2017 edition). Chin J Diabetes Mellitus. 2018;10:4\u201367.","journal-title":"Chin J Diabetes Mellitus"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163424"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2012.00194.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e197"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-079061"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7564.362"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.563213"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.015"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0177-4"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01686-3"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.149"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2023.2218684"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/dbi16-0014"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-019-06915-8"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000216787.85457.f3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16621"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01375-3"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70550"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.10.043"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.012901"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01585-7"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.125.056010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:37:26Z","timestamp":1785958646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.125.056010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1161\/STROKEAHA.125.056010"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.125.056010","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}