{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:59:12Z","timestamp":1790744352824,"version":"4.1.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Magnetic resonance imaging (MRI) is a cornerstone of neurological care, serving as the gold standard for diagnosing pathologies, such as brain tumors and, together with computed tomography, stroke. However, the high capital costs, specialized infrastructure requirements such as expensive and bulky radiofrequency-shielding cages, and the operational complexity of conventional high-field scanners (1.5T and 3T) largely confine MRI to centralized imaging facilities. This scenario often leads to reliance on brain computed tomography or ultrasound in point-of-care settings, despite MRI\u2019s superior soft-tissue contrast for diagnosis and prognosis. In the past decade, there has been renewed interest in compact and simplified ultra-low-field (under 0.1T) MRI scanners, fueled by advances in engineering and computing. Here, we review the recent developments in ultra-low-field brain MRI, which enable imaging in open environments and demonstrate initial clinical applicability in point-of-care settings. We also envision future developments along 3 focus areas (ie, hardware, imaging protocols, and data-driven image formation and analysis) to address the current limitations of image quality and contrast in ultra-low-field brain MRI systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.126.052978","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:02:08Z","timestamp":1784624528000},"page":"2577-2589","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Ultra-Low-Field Brain MRI for Point-of-Care Applications: A Technology Review"],"prefix":"10.1161","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-1546","authenticated-orcid":true,"given":"Ed X.","family":"Wu","sequence":"first","affiliation":[{"name":"Laboratory of Biomedical Imaging and Signal Processing (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."},{"name":"Department of Electrical and Computer Engineering (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-887X","authenticated-orcid":true,"given":"Yujiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Imaging and Signal Processing (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."},{"name":"Department of Electrical and Computer Engineering (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-7982","authenticated-orcid":true,"given":"Yilong","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau CNS Regeneration Institute, Jinan University, Guangzhou, China (Y.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1417-470X","authenticated-orcid":true,"given":"Ye","family":"Ding","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Imaging and Signal Processing (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."},{"name":"Department of Electrical and Computer Engineering (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-6307","authenticated-orcid":true,"given":"Lawrence L.","family":"Wald","sequence":"additional","affiliation":[{"name":"A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown (L.L.W., J.E.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Eugenio","family":"Iglesias","sequence":"additional","affiliation":[{"name":"A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown (L.L.W., J.E.I.)."},{"name":"Hawkes Institute, University College London, United Kingdom (J.E.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-9732","authenticated-orcid":true,"given":"Andrew G.","family":"Webb","sequence":"additional","affiliation":[{"name":"C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, the Netherlands (A.G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-3497","authenticated-orcid":true,"given":"J\u00fcrgen","family":"Hennig","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Physics, Faculty of Medicine, University of Freiburg, Germany (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-3057","authenticated-orcid":true,"given":"Gilberto K.K.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Surgery, Li Ka Shing Faculty of Medicine (G.K.K.L.), The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-0445","authenticated-orcid":true,"given":"Alex T.L.","family":"Leong","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Imaging and Signal Processing (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."},{"name":"Department of Electrical and Computer Engineering (E.X.W., Y.Z., Y.D., A.T.L.L.), The University of Hong Kong, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199303113281008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.3263"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27317-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00086-w"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-023-01104-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-00641-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28396"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adm7168"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/242190a0"},{"key":"e_1_3_2_11_2","first-page":"97","article-title":"NMR in cancer: XVI. 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