{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:49Z","timestamp":1787757889942,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Older randomized trials have shown modest benefit for carotid endarterectomy for selected patients with asymptomatic carotid stenosis compared with medical treatment. However, improvements in contemporary medical therapy may have negated the benefit of carotid endarterectomy, and no large randomized trials comparing stenting with modern medical treatment have been completed. The recently reported CREST-2 trial (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials) addressed these evidence gaps. We describe the main results of CREST-2 and our interpretation of the findings for clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.126.054415","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:00:42Z","timestamp":1784883642000},"page":"2952-2955","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Medical Treatment or Intervention for Asymptomatic Carotid Stenosis?: Interpreting CREST-2"],"prefix":"10.1161","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-6565","authenticated-orcid":true,"given":"Peter","family":"Kelly","sequence":"first","affiliation":[{"name":"Stroke Clinical Trials Network Ireland, University College Dublin (P.K., J.M.)."},{"name":"Department of Neurology (P.K.), Stroke Service and Mater University Hospital Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-1303","authenticated-orcid":true,"given":"John","family":"McCabe","sequence":"additional","affiliation":[{"name":"Stroke Clinical Trials Network Ireland, University College Dublin (P.K., J.M.)."},{"name":"Department of Medicine for Elderly (J.M.), Stroke Service and Mater University Hospital Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-4141","authenticated-orcid":true,"given":"Gert Jan","family":"De Borst","sequence":"additional","affiliation":[{"name":"Research Chair, Department of Vascular Surgery, University Medical Center Utrecht, the Netherlands (G.J.D.B.)."},{"name":"Chair Board of Directors, Reinier de Graaf Gasthuis, Delft, the Netherlands (G.J.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2022.04.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.041921"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520420037035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16146-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00290-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00107-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2508800"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241234238"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.077549"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2025.08.022"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2024.05.048"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.9143"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.126.054415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:57:27Z","timestamp":1787756247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.126.054415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1161\/STROKEAHA.126.054415"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.126.054415","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}