{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:25:36Z","timestamp":1787757936179,"version":"build-2784847793"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Brain perivascular spaces (PVS) are emerging magnetic resonance imaging markers of microvascular function and waste metabolite clearance. Although PVS enlargement has been linked to aging and vascular risk, it remains unclear whether PVS morphometry reflects shared familial microvascular characteristics and how these are shaped by individual vascular, physiological, and neuropsychiatric factors. We investigated whether PVS morphometry captures these familial characteristics in addition to individual determinants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We analyzed 1183 participants from the Stratifying Depression and Resilience Longitudinally family-based cohort, including 324 individuals with first-degree relatives. Automated magnetic resonance imaging segmentation quantified PVS volume, count, density, and median length in the centrum semiovale and basal ganglia. Linear mixed-effects models assessed associations with age, hypertension, hair cortisol, depressive symptom scores, and hand grip strength while accounting for familial clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In 1050 individuals (59.5% female; mean age, 59.3\u00b110.1 years), PVS burden increased with age (PVSvolume%ROI, \u03b2=0.18 [95% CI, 0.11\u20130.26];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001), current depressive symptoms across both regions (PVS density: centrum semiovale, \u03b2=0.092 [0.023\u20130.16];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.009; BG, \u03b2=0.11 [0.043\u20130.18];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002; largely robust to false discovery rate correction), and with higher hair cortisol (PVS count \u03b2=0.08 [0.003\u20130.15];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.041; borderline after false discovery rate correction) and weaker grip strength (PVSvolume%ROI \u03b2=\u22120.09 [\u22120.16 to \u22120.02];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.013), in the centrum semiovale. Familial clustering was significant for PVS volume (\u03b2=0.22 [0.096\u20130.52];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.013) and median length (\u03b2=0.28 [0.16\u22120.49];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0003), independent of other factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>PVS morphometry reflects shared familial microvascular phenotypes and neuropsychiatric influences beyond hypertension, highlighting both familial and individual determinants of PVS burden and morphology. These findings support PVS morphometry as a neuroimaging marker of cerebral microvascular health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.126.055378","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:00:16Z","timestamp":1784278816000},"page":"2768-2779","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Perivascular Space Morphometry Reflects Shared Familial Microvascular Architecture and Neuropsychiatric Influences"],"prefix":"10.1161","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-0886","authenticated-orcid":true,"given":"Alexandra","family":"Morozova","sequence":"first","affiliation":[{"name":"Centre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.)."},{"name":"Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czechia (A. Morozova)."},{"name":"Krembil Brain Institute, University Health Network, Toronto, ON, Canada (A. Morozova)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-6546","authenticated-orcid":true,"given":"Maria del C.","family":"Vald\u00e9s Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.)."},{"name":"UK Dementia Research Institute at The University of Edinburgh, Edinburgh, United Kingdom (M.C.V.H., R.D.C., J.M.W.)."},{"name":"Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, ) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-2163","authenticated-orcid":true,"given":"Roberto","family":"Duarte Coello","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.)."},{"name":"UK Dementia Research Institute at The University of Edinburgh, Edinburgh, United Kingdom (M.C.V.H., R.D.C., J.M.W.)."},{"name":"Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, ) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-8869","authenticated-orcid":true,"given":"Heather C.","family":"Whalley","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.)."},{"name":"Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, ) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-4588","authenticated-orcid":true,"given":"Andrew","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-4129","authenticated-orcid":true,"given":"Anca-Larisa","family":"Sandu Giuraniuc","sequence":"additional","affiliation":[{"name":"Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, ) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.)."},{"name":"School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom (A.-L.S.G., G.D.W., C.J.M.N., A.D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-9845","authenticated-orcid":true,"given":"Gordon D.","family":"Waiter","sequence":"additional","affiliation":[{"name":"Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, ) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.)."},{"name":"School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom (A.-L.S.G., G.D.W., C.J.M.N., A.D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"McNeil","sequence":"additional","affiliation":[{"name":"Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, ) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.)."},{"name":"School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom (A.-L.S.G., G.D.W., C.J.M.N., A.D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-8753","authenticated-orcid":true,"given":"J. 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