{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:49:42Z","timestamp":1791539382402,"version":"4.3.4"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Although Constraint-Induced Movement Therapy is increasingly recommended as an evidence-based, intensive treatment for children with hemiparesis, parent perspectives are lacking. I-ACQUIRE, a multicomponent form of Constraint-Induced Movement Therapy, involves substantial parent participation. Child outcomes from the United States 15-site I-ACQUIRE phase 3 clinical trial (2019\u20132025), partnered with a Parent Council, are presented elsewhere. Here, we examine complementary lived-experience parent data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>All parents (167) of infants\/toddlers with perinatal arterial ischemic stroke and hemiparesis consented to child random assignment to usual treatment (UT), moderate-dose I-ACQUIRE (3 h\/d, 5 d\/wk over 4 weeks), or high-dose I-ACQUIRE (6 h\/d). Parents completed assessments about life- and therapy-related stress, treatment concerns, observations of child progress, and perceived therapy-related responsibilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Parents of children in the I-ACQUIRE moderate-dose (56) and high-dose group (58), compared with UT (53), reported lower rates of concerns or problems that therapy did not produce clear benefits (\u22644% versus 18%), child-therapist interactions (\u22642% versus 24%), and parent-therapist interactions (\u22642% versus 6%). I-ACQUIRE versus UT parents had higher proportions of positive feelings that therapy was useful (94%\u201398% versus 83%); interesting (96%\u201398% versus 79%), important (94%\u201398% versus 85%), and fun (78%\u201384% versus 53%); and provided comforting (72%\u201383% versus 47%) and relaxing benefits (28%\u201331% versus 17%). In all groups, similar proportions reported their role was stressful (I-ACQUIRE 26%\u201328%, UT 32%), difficult (I-ACQUIRE 35%\u201348%, UT 38%), and tiring (I-ACQUIRE 48%\u201352%, UT 43%). General life stress scores were mostly in the moderate-range category, similar across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Parents of I-ACQUIRE children reported higher positive feelings and notably fewer concerns about lack of benefits compared with UT. Across all groups, some parents (&lt;52%) reported treatment-related stress, difficulty, and fatigue. These findings provide new perspectives from parents\u2019 lived experiences to help families and clinicians in treatment decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03910075.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.126.055913","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:00:49Z","timestamp":1791536449000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Parent Perspectives on I-ACQUIRE Therapy"],"prefix":"10.1161","clinical-trial-number":[{"clinical-trial-number":"nct03910075","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5029-5173","authenticated-orcid":true,"given":"Mara M.","family":"Yale","sequence":"first","affiliation":[{"name":"I-ACQUIRE Parent Council member; Parent of a stroke survivor (M.M.Y., K.A.H., J.F.M.)."},{"name":"Mass General Hospital, Boston, MA (M.M.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3885-1393","authenticated-orcid":true,"given":"Kimberly A.","family":"Hindery","sequence":"additional","affiliation":[{"name":"I-ACQUIRE Parent Council member; Parent of a stroke survivor (M.M.Y., K.A.H., J.F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3166-636X","authenticated-orcid":true,"given":"Jennifer F.","family":"Murray","sequence":"additional","affiliation":[{"name":"I-ACQUIRE Parent Council member; Parent of a stroke survivor (M.M.Y., K.A.H., J.F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-2057","authenticated-orcid":true,"given":"Amy R.","family":"Darragh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig T.","family":"Ramey","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke (C.T.R., S.C.D., M.R.T., S.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke (C.T.R., S.C.D., M.R.T., S.L.R.)."},{"name":"Virginia Tech Carilion School of Medicine, Virginia Tech, Roanoke (S.C.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-698X","authenticated-orcid":true,"given":"Qi","family":"Pauls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-1332","authenticated-orcid":true,"given":"Jill C.","family":"Heathcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-8977","authenticated-orcid":true,"given":"Warren D.","family":"Lo","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital, Columbus, OH (W.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-681X","authenticated-orcid":true,"given":"Renee H.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3643-9094","authenticated-orcid":true,"given":"Mary Rebekah","family":"Trucks","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke (C.T.R., S.C.D., M.R.T., S.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-7019","authenticated-orcid":true,"given":"Sharon Landesman","family":"Ramey","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke (C.T.R., S.C.D., M.R.T., S.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2021.02.002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00503-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.4898"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/children11050515"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.125.053375"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21903"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/children12060804"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.0878"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/pedsos.2025-000676"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023-064477"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anr.2012.08.004"},{"key":"e_1_3_3_14_2","first-page":"31","volume-title":"The social psychology of health","author":"Cohen S","unstructured":"Cohen S, Williamson G. Perceived stress in a probability sample of the United States. In: Spacapan S, Oskamp S, eds. The social psychology of health. Sage Publications, Inc; 1988:31\u201367; 251:chap 3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_3_3_16_2","first-page":"P60","volume-title":"Income and poverty in the United States: 2020. US census bureau, current population reports","author":"Shrider EA","year":"2021","unstructured":"Shrider EA, Kollar M, Chen F, Semega J. Income and poverty in the United States: 2020. US census bureau, current population reports. 2021;P60\u2013273"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cch.13190"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0000000000001219"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/edpract-2011-300593"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-025-10033-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13900"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-033878"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.126.055913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:00:51Z","timestamp":1791536451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.126.055913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":21,"alternative-id":["10.1161\/STROKEAHA.126.055913"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.126.055913","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"STROKEAHA.126.055913"}}