{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:46:09Z","timestamp":1791899169273,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Anti-inflammatory therapies reduce the risk of major adverse cardiovascular events (MACEs) in coronary disease, but efficacy has not been shown after stroke. It is uncertain if patients with atherosclerosis are more likely to benefit from anti-inflammatory prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed a post hoc analysis of the CONVINCE trial (randomized, open-label, blinded-end point assessed; Colchicine for Prevention of Vascular Inflammation in Non-Cardioembolic Stroke), comparing colchicine 0.5 mg plus usual care versus usual care. We performed a subgroup analysis in patients stratified according to the presence\/absence of atherosclerosis (defined as cervico-cranial\/aortic artery plaque, coronary disease, peripheral arterial disease, and carotid revascularization). The primary outcome was MACE. Analyses were adjusted for age, qualifying event, time from event to randomization, and coronary disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Three thousand one hundred forty-four participants were included. There were 338 MACE events during follow-up (median, 33.6 months). On intention-to-treat analysis, there were numerically fewer MACE events in the atherosclerosis group assigned to colchicine (105 [11.1%], 3.88 [95% CI, 3.21\u20134.70] per 100 person-years) versus usual care (132 [14.2%], 4.83 [4.07\u20135.73] per 100 person-years), which was not statistically significant (hazard ratio [HR], 0.83 [95% CI, 0.64\u20131.07]). There was no difference in the rate of the primary outcome according to treatment allocation in the nonatherosclerosis subgroup (HR, 0.94 [95% CI, 0.64\u20131.39];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.60). There was a nonsignificant reduced risk of recurrent ischemic stroke in the colchicine arm (HR, 0.76 [95% CI, 0.56\u20131.05]) in the atherosclerosis group, but no difference in events was observed in the nonatherosclerotic group (HR, 0.92 [95% CI, 0.60\u20131.42];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.48). In the prespecified on-treatment analysis, colchicine reduced the risk of MACE in patients with atherosclerosis (HR, 0.76 [95% CI, 0.58\u20130.99]) but not without (HR, 0.95 [95% CI, 0.63\u20131.42];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.37).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>There were no significant between-group interactions for colchicine and atherosclerosis for MACE in intention-to-treat or on-treatment populations. However, outcome events were numerically fewer in patients with atherosclerosis assigned to colchicine, and significant benefit was observed in the on-treatment analysis in this group. Data suggest that the presence of atherosclerosis should be an inclusion criterion in future anti-inflammatory therapy trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02898610.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.126.056561","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:00:19Z","timestamp":1787216419000},"page":"2981-2990","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Colchicine for Secondary Prevention After Stroke According to the Presence of Atherosclerosis"],"prefix":"10.1161","volume":"57","clinical-trial-number":[{"clinical-trial-number":"nct02898610","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-1303","authenticated-orcid":true,"given":"John J.","family":"McCabe","sequence":"first","affiliation":[{"name":"Health Research Board, Stroke Clinical Trials Network Ireland, Dublin (J.J.M., C. Walsh, J.H., M.O., P.J.K.)."},{"name":"School of Medicine, University College Dublin, Ireland (J.J.M., P.J.K.)."},{"name":"Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland (J.J.M., P.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-5956","authenticated-orcid":true,"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospitals Leuven, Belgium (R.L.)."},{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Belgium (R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-5968","authenticated-orcid":true,"given":"Francisco","family":"Purroy","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Group, Institut de Recerca Biom\u00e8dica de Lleida, University of Lleida, Spain (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathal","family":"Walsh","sequence":"additional","affiliation":[{"name":"Health Research Board, Stroke Clinical Trials Network Ireland, Dublin (J.J.M., C. Walsh, J.H., M.O., P.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weimar","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital, University Duisburg-Essen, Germany (C. Weimar)."},{"name":"BDH clinic Elzach, Germany (C. Weimar)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-1866","authenticated-orcid":true,"given":"Anna","family":"Czlonkowska","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neurology, Warsaw, Poland (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-4051","authenticated-orcid":true,"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Bern and University of Bern, Switzerland (U.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-5526","authenticated-orcid":true,"given":"Ana Catarina","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Department of Neurosciences and Mental Health (Neurology), Hospital Santa Maria-CHLN, Centro de Estudos Egas Moniz, Universidade de Lisboa, Portugal (A.C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6269-1543","authenticated-orcid":true,"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences &amp; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary and Foothills Medical Centre, AB, Canada (M.D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-4795","authenticated-orcid":true,"given":"Dalius","family":"Jatuzis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Centre of Neurology, Institute of Clinical Medicine, Vilnius University, Lithuania (D.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-0727","authenticated-orcid":true,"given":"Janika","family":"K\u00f5rv","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-0523","authenticated-orcid":true,"given":"Christina","family":"Kruuse","sequence":"additional","affiliation":[{"name":"Department of Neurology, Copenhagen University Hospital-Herlev Gentofte and Department of Brain and Spinal Cord Injury, Copenhagen University Hospital-Rigshospitalet, Denmark (C.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7458-5166","authenticated-orcid":true,"given":"Robert","family":"Mikulik","sequence":"additional","affiliation":[{"name":"International Clinical Research Center and Department of Neurology, St Anne\u2019s University Hospital and Masaryk University Brno, Czech Republic (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Navabi","sequence":"additional","affiliation":[{"name":"Department of Neurology with Stroke Unit, Vivantes Hospital Neuk\u00f6lln, Berlin, Germany (D.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-5751","authenticated-orcid":true,"given":"Joseph","family":"Harbison","sequence":"additional","affiliation":[{"name":"Health Research Board, Stroke Clinical Trials Network Ireland, Dublin (J.J.M., C. Walsh, J.H., M.O., P.J.K.)."},{"name":"Stroke Service, Department of Geriatric Medicine, St. James\u2019s Hospital, Dublin, Ireland (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-9204","authenticated-orcid":true,"given":"Margaret","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Health Research Board, Stroke Clinical Trials Network Ireland, Dublin (J.J.M., C. Walsh, J.H., M.O., P.J.K.)."},{"name":"Department of Geriatric Medicine, University Hospital Limerick, Ireland (M.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-6352","authenticated-orcid":true,"given":"Helle Klingenberg","family":"Iversen","sequence":"additional","affiliation":[{"name":"Clinical Stroke Research Unit, Department of Neurology, University Hospital-Rigshospitalet, University of Copenhagen, Denmark (H.K.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0598-8771","authenticated-orcid":true,"given":"Katja","family":"Adie","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospital, Truro, United Kingdom (K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Nederkoorn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam University Medical Centers, Netherlands (P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-3157","authenticated-orcid":true,"given":"Christopher","family":"Price","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, United Kingdom (C.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-6565","authenticated-orcid":true,"given":"Peter J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Health Research Board, Stroke Clinical Trials Network Ireland, Dublin (J.J.M., C. Walsh, J.H., M.O., P.J.K.)."},{"name":"School of Medicine, University College Dublin, Ireland (J.J.M., P.J.K.)."},{"name":"Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland (J.J.M., P.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007267"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003657"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.589044"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00306-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61717-7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013274"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040529"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00700-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035905"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.072238"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3344"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873231168367"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00067-4"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102835"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00968-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-079061"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987320972566"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056171"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.027"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021372"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405922"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050771"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069808"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231207777"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012909"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035202"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208016"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214701"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000260091.13729.96"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027272"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214214"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873251329993"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.126.056561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:52:15Z","timestamp":1791895935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.126.056561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1161\/STROKEAHA.126.056561"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.126.056561","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}