{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:40:13Z","timestamp":1792662013670,"version":"4.5.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The carotid Plaque Reporting and Data System (Plaque-RADS) provides a standardized framework for evaluating plaque morphology, but prospective validation remains limited. We investigated the association between computed tomography angiography-based Plaque-RADS categories and subsequent ischemic events in patients with noncardioembolic stroke\/transient ischemic attack, from a completed clinical trial of colchicine. Second, we assessed whether the effect of colchicine differed by Plaque-RADS risk classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a posthoc observational cohort analysis of 517 participants in the CONVINCE trial (Colchicine for Prevention of Vascular Inflammation in Non-CardioEmbolic Stroke) from 13 European sites. Associations between Plaque-RADS and recurrent ipsilateral stroke, any stroke\/transient ischemic attack, and major adverse cardiovascular events were assessed using multivariable Cox proportional hazards models. Plaque-RADS was analyzed as both dichotomized (&lt;3 versus \u22653) and ordinal (per 1-point increase) variables. Treatment effects were assessed by Plaque-RADS classification using interaction and stratified analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 510 patients (median age, 67.0 years; 72.2% male) with 966 internal carotid arteries were included. Among 321 internal carotid arteries ipsilateral to the index ischemic stroke, 12 recurrent ipsilateral strokes, 32 any strokes\/transient ischemic attacks, and 37 major adverse cardiovascular events occurred over a median 35.7-month follow-up. Plaque-RADS \u22653 (n=140) was independently associated with recurrent ipsilateral stroke (adjusted hazard ratio, 7.80 [95% CI, 1.55\u201339.30];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), any stroke\/transient ischemic attack (adjusted hazard ratio, 3.94 [95% CI, 1.68\u20139.24];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01), and major adverse cardiovascular events (adjusted hazard ratio, 2.52 [95% CI, 1.19\u20135.34];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02) after adjustment for age, sex and cardiovascular risk factors. A significant interaction with colchicine treatment was observed for major adverse cardiovascular events (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.047), with greater benefit among patients with Plaque-RADS scores \u22653 (hazard ratio, 0.35 [95% CI, 0.15\u20130.82]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In internal carotid arteries ipsilateral to the index ischemic stroke, computed tomography angiography-based carotid Plaque-RADS was associated with recurrent ischemic stroke and cardiovascular events. Importantly, treatment effects of colchicine varied across Plaque-RADS classification (&lt;3 versus \u22653), suggesting that plaque vulnerability assessment may help refine patient selection for anti-inflammatory therapy beyond stenosis-based classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02898610.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.126.057740","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:00:19Z","timestamp":1792659619000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Computed-Tomography Angiography-Based Carotid Plaque-RADS, Recurrent Vascular Events, and the Effect of Colchicine: An Imaging Substudy of the CONVINCE Randomized Trial"],"prefix":"10.1161","clinical-trial-number":[{"clinical-trial-number":"nct02898610","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-7645","authenticated-orcid":true,"given":"Louise","family":"Maes","sequence":"first","affiliation":[{"name":"Department of Neurology (L.M., A.W., J.D., R.L.), University Hospitals Leuven, Belgium."},{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven\u2014University of Leuven, Belgium (L.M., A.W., J.D., D.B., R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-2699","authenticated-orcid":true,"given":"Anke","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.M., A.W., J.D., R.L.), University Hospitals Leuven, Belgium."},{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven\u2014University of Leuven, Belgium (L.M., A.W., J.D., D.B., R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-0388","authenticated-orcid":true,"given":"Jo P.","family":"Peluso","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology (J.P.P.), University Hospitals Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-0237","authenticated-orcid":true,"given":"Jelle","family":"Demeestere","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.M., A.W., J.D., R.L.), University Hospitals Leuven, Belgium."},{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven\u2014University of Leuven, Belgium (L.M., A.W., J.D., D.B., R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-6184","authenticated-orcid":true,"given":"Philippe","family":"Desfontaines","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit, CHC Groupe Sant\u00e9, Li\u00e8ge, Belgium (P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adinda","family":"De Pauw","sequence":"additional","affiliation":[{"name":"Department of Neurology, AZ Damiaan, Oostende, Belgium (A.D.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-8266","authenticated-orcid":true,"given":"Ronan","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Neurology and Department of Geriatric and Stroke Medicine, Tallaght University Hospital-The Adelaide and Meath Hospital, incorporating the National Children\u2019s Hospital and Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Ireland (R.C.)."},{"name":"Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland (R.C., D.J.H.M.C., S.C., D.J.W., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-4516","authenticated-orcid":true,"given":"Dominick J.H.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland (R.C., D.J.H.M.C., S.C., D.J.W., P.K.)."},{"name":"Department of Neurology, Tallaght University Hospital\/Adelaide and Meath Hospital, Dublin, Incorporating the National Children\u2019s Hospital (AMNCH), Tallaght, Ireland (D.J.H.M.C.)."},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College, Dublin, Ireland (D.J.H.M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-8463","authenticated-orcid":true,"given":"Simon","family":"Cronin","sequence":"additional","affiliation":[{"name":"Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland (R.C., D.J.H.M.C., S.C., D.J.W., P.K.)."},{"name":"School of Medicine, University College Cork, Ireland (S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-462X","authenticated-orcid":true,"given":"David J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland (R.C., D.J.H.M.C., S.C., D.J.W., P.K.)."},{"name":"RCSI University of Medicine and Health Sciences and Beaumont Hospital, Dublin, Ireland (D.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-2024","authenticated-orcid":true,"given":"Sylvie","family":"De Raedt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universitair Ziekenhuis Brussel, NEUR Research group, Vrije Universiteit Brussel, Belgium (S.D.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-5968","authenticated-orcid":true,"given":"Francisco","family":"Purroy","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Hospitalt Universitari Arnau de Vilanova de Lleida, Spain (F.P.)."},{"name":"Biomedical Research Institute of Lleida, Universitat de Lleida, Spain (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-9346","authenticated-orcid":true,"given":"Geert","family":"Vanhooren","sequence":"additional","affiliation":[{"name":"Department of Neurology, AZ Sint-Jan, Brugge, Belgium (G.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Pope","sequence":"additional","affiliation":[{"name":"HRB Clinical Research Facility, University College Cork, Ireland (G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-5123","authenticated-orcid":true,"given":"Peter","family":"Vanacker","sequence":"additional","affiliation":[{"name":"Department of Neurology, AZ Groeninge, Kortrijk, Belgium (P.V.)."},{"name":"Department of Neurology, University Hospitals Antwerp, Belgium (P.V.)."},{"name":"Department of Translational Neuroscience, University of Antwerp, Belgium (P.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3156-7302","authenticated-orcid":true,"given":"Tim","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, St. Vincent\u2019s University Hospital, Ireland (T.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh","family":"Nerney","sequence":"additional","affiliation":[{"name":"School of Medicine, University College Dublin (UCD), Ireland (D.N., P.K.)."},{"name":"Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland (D.N., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathal","family":"Walsh","sequence":"additional","affiliation":[{"name":"TCD Biostatistics Unit, Discipline of Public Health and Primary Care, School of Medicine, Trinity College Dublin, Ireland (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-2603","authenticated-orcid":true,"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven\u2014University of Leuven, Belgium (L.M., A.W., J.D., D.B., R.L.)."},{"name":"Department of Radiology and Nuclear Medicine (D.B.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands."},{"name":"Department of Epidemiology (D.B.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-6565","authenticated-orcid":true,"given":"Peter","family":"Kelly","sequence":"additional","affiliation":[{"name":"Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI), Dublin, Ireland (R.C., D.J.H.M.C., S.C., D.J.W., P.K.)."},{"name":"School of Medicine, University College Dublin (UCD), Ireland (D.N., P.K.)."},{"name":"Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland (D.N., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-5956","authenticated-orcid":true,"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.M., A.W., J.D., R.L.), University Hospitals Leuven, Belgium."},{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven\u2014University of Leuven, Belgium (L.M., A.W., J.D., D.B., R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Cardiovascular diseases fact sheet","author":"Organisation WH","year":"2021","unstructured":"Organisation WH. Cardiovascular diseases fact sheet. 2021"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.02.028"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002354"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002978"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06425-w"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027272"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.09.005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2024.07.004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214801"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2025.10.009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2024.07.001"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314817"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001168"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00968-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987320972566"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5461"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.04.003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf210"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/esj\/aakag033"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/esj\/aakag023.1882"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873251329993"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2025.4206"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930251406818"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162204"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A9139"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.048305"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8819"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2025.04.051"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7921"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.03.028"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.09.064"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23553"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025422"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012909"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13040645"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2020.12.005"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf707"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8769"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.22.6.711"},{"key":"e_1_3_3_42_2","first-page":"2086","article-title":"Identification, prognosis, and management of patients with carotid artery near occlusion.","volume":"26","author":"Fox AJ","year":"2005","unstructured":"Fox AJ, Eliasziw M, Rothwell PM, Schmidt MH, Warlow CP, Barnett HJ. Identification, prognosis, and management of patients with carotid artery near occlusion. AJNR Am J Neuroradiol. 2005;26:2086\u20132094","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4432"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023015"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.07.046"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-09025-6"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.126.057740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:00:20Z","timestamp":1792659620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.126.057740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":45,"alternative-id":["10.1161\/STROKEAHA.126.057740"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.126.057740","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"2026-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"STROKEAHA.126.057740"}}