{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:16:57Z","timestamp":1773933417869,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">When standard endovascular thrombectomy techniques fail to achieve a successful recanalization, it is often necessary to use rescue therapies (RTs). RTs are more commonly used in basilar artery occlusions and conventionally thought to represent \u201ca last resort option.\u201d We sought to study the outcomes of basilar artery occlusion patients who received RT, and further hypothesize that the number of instrumental passes before initiation of RT may be associated with increased risk for poor clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We performed a retrospective analysis of the ETIS (\u201cEndovascular Treatment in Ischemic Stroke\u201d) registry. Our primary analysis included 277 patients who underwent thrombectomy for basilar artery occlusion, of whom 74 patients (26.7%) who received RT, defined as the use of intra\u2010arterial drugs, angioplasty, or stenting. Primary outcome measures included successful or complete reperfusion (final modified thrombolysis in cerebral infarction \u22652b or 3), functional independence (modified Rankin scale of 0\u20132), and mortality at 3\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">RT patients were more likely to have an atherosclerotic cause than non\u2010RT patients (46\/74 [62.2%] versus 38\/203 [18.7%]), were more likely to die (42\/74 [56.8%] versus 73\/203 [36.0%]), and were less likely to achieve functional independence (12\/74 [16.2%] versus 84\/203 [41.4%]). In the RT cohort, 17 of 74 patients (23.0%) had 1 pass before RT initiation, and 8 of 17 (47.1%) achieved a modified Rankin scale score of 0 to 2 at 3 months, with a mortality rate of 23.5% (4\/17). The chance of achieving good clinical outcome decreased with each additional pass, whereas mortality increased. The odds of mortality at 3 months were highest in the &gt;3 passes group, with an odds ratio of 10.29 (95% CI, 2.42\u201343.81) compared with 1 pass. None of the 25 patients with &gt;3 passes before RT achieved 3\u2010month functional independence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">There is a significant correlation between the number of passes before initiation of RT and 3\u2010month clinical outcomes in basilar artery occlusion patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.121.000118","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T12:02:17Z","timestamp":1643112137000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Number of Passes Before Rescue Therapy in Thrombectomy for Basilar Artery Strokes"],"prefix":"10.1161","volume":"2","author":[{"given":"Ronda","family":"Lun","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute and University of Ottawa","place":["Ottawa, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Walker","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute and University of Ottawa","place":["Ottawa, Canada"]},{"name":"University of British Columbia","place":["New Westminster, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Weisenburger\u2010Lile","sequence":"additional","affiliation":[{"name":"Foch Hospital","place":["Suresnes, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Foch Hospital","place":["Suresnes, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien","family":"Guenego","sequence":"additional","affiliation":[{"name":"Fondation Rothschild Hospital","place":["Paris, France"]},{"name":"Erasme University 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France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Gory","sequence":"additional","affiliation":[{"name":"CHRU\u2010Nancy","place":["Nancy, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Richard","sequence":"additional","affiliation":[{"name":"CHRU\u2010Nancy","place":["Nancy, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lina","family":"Ducroux","sequence":"additional","affiliation":[{"name":"Fondation Rothschild Hospital","place":["Paris, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Piotin","sequence":"additional","affiliation":[{"name":"Fondation Rothschild Hospital","place":["Paris, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Blanc","sequence":"additional","affiliation":[{"name":"Fondation Rothschild Hospital","place":["Paris, 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France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Vannier","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Pontchaillou","place":["Rennes, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Guillen","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Pontchaillou","place":["Rennes, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Eugene","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Pontchaillou","place":["Rennes, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Maier","sequence":"additional","affiliation":[{"name":"Fondation Rothschild Hospital","place":["Paris, 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