{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:20:08Z","timestamp":1753881608976,"version":"3.41.2"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Early neurologic deterioration (END) occurs in a quarter of acute lacunar infarcts, but the underlying pathophysiological features are poorly understood. We sought to determine the association between luminal stenosis (&lt;50%) of the parent artery and END.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This observational study included consecutive patients with lacunar stroke from the ischemic stroke registries of New York University Langone Health and Brown University. All included patients were admitted for acute lacunar stroke, which was defined as a subcortical infarct &lt;1.5\u00a0cm on computed tomography or &lt;2 cm on diffusion\u2010weighted imaging without significant stenosis (&gt;50%) in the parent vessel and no cardioembolic source. We defined END as any neurologic deterioration referable to the acute lacunar stroke and not related to a medical or noncerebrovascular neurological complication. We used univariate and logistic regression analyses to determine associations between luminal stenosis (&lt;50%) and the odds of END. Furthermore, we attempted to validate findings using the Columbia University Medical Center stroke registry and perform a meta\u2010analysis combining the derivation and validation groups because of the expected small samples and event rates.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The New York University Langone Health and Brown University sample included 205 patients, of whom 41 (20%) had END. In adjusted models, we found no definite association between luminal stenosis (&lt;50%) and END (adjusted odds ratio [OR], 1.74; 95% CI, 0.73\u20134.14). From Columbia University Medical Center, 361 total patients were included, of whom 59 (16%) had END. In adjusted models, we found an association between luminal stenosis (&lt;50%) and END (adjusted OR, 2.28; 95% CI, 1.15\u20134.50). Meta\u2010analysis of both cohorts found luminal stenosis (&lt;50%) associated with END (relative risk, 1.69; 95% CI, 1.17\u20132.43).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this multicenter study, luminal stenosis (&lt;50%) may be associated with END following an acute lacunar infarct. Larger studies using vessel wall imaging are needed to validate our findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.121.000132","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T13:42:56Z","timestamp":1640180576000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mild Luminal Stenosis of Parent Artery and Neurologic Deterioration After Acute Lacunar Stroke"],"prefix":"10.1161","volume":"2","author":[{"given":"Dixon","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, New York University Grossman School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawna","family":"Cutting","sequence":"additional","affiliation":[{"name":"Department of Neurology Brown University Providence RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan","family":"Raz","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University Grossman School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kursat","family":"Gurel","sequence":"additional","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University Grossman School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Mac Grory","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Scher","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University Grossman School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahnaz","family":"Pirooz","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University Grossman School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam de","family":"Havenon","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koto","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University Grossman School of Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Furie","sequence":"additional","affiliation":[{"name":"Department of Neurology Brown University Providence RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell S.V.","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York NY"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-1004","authenticated-orcid":false,"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Department of Neurology Brown University Providence RI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00789.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000210457.89798.0e"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/01.STR.0000016326.78014.FE","article-title":"Lacunar stroke is the major cause of progressive motor deficits","volume":"33","author":"Steinke W","year":"2002","unstructured":"Steinke W, Ley SC. 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