{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:32:18Z","timestamp":1785767538947,"version":"3.56.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to compare outcomes after stroke due to anterior circulation large vessel occlusion with initial imaging assessments using diffusion\u2010weighted imaging (DWI) or noncontrast computed tomography (NCCT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Among 2399 patients with large vessel occlusion stroke in a prospective, multicenter registry, patients with (1) prestroke modified Rankin Scale scores 0 to 1, (2) occlusion of the internal carotid artery or M1 segment of the middle cerebral artery, and (3) onset\u2010to\u2010hospital\u2010arrival time &lt;6\u00a0hours were included. The primary effectiveness outcome was good functional outcome, defined as modified Rankin Scale scores 0 to 2 at 3 months. Safety outcomes included symptomatic intracranial hemorrhage. Intergroup biases were accounted for by mixed\u2010effects multivariable modeling and inverse probability of treatment weighting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 343 patients (130 women [37.9%]; median age, 74 years [interquartile range, IQR, 66\u201382 years]) were analyzed. DWI\u2010based assessment was performed in 217 patients, and NCCT\u2010based assessment was performed in 126 patients. The DWI group showed a lower baseline National Institutes of Health Stroke Scale score (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and lower Alberta Stroke Program Early CT Score (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) than the NCCT group. Frequency of endovascular therapy was lower in the DWI group (71.9%) than in the NCCT group (84.1%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Median hospital\u2010arrival\u2010to\u2010arterial\u2010puncture time was 55 minutes (IQR, 40\u201377.5 minutes) in the DWI group and 55 minutes (IQR, 35\u201380 minutes) in the NCCT group (\n              <jats:italic>P<\/jats:italic>\n              =0.89), with similar rates of successful recanalization (77.6% versus 76.4%, respectively;\n              <jats:italic>P<\/jats:italic>\n              =0.88). Frequency of good functional outcome was 47.0% in the DWI group and 41.3% in the NCCT group (adjusted odds ratio, 1.32; 95% CI, 0.49\u20133.55). Symptomatic intracranial hemorrhage was encountered in 2.8% in the DWI group and 1.6% in the NCCT group (\n              <jats:italic>P<\/jats:italic>\n              =0.71).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Potential difference in accuracy of ischemic damage assessment between the 2 modalities did not seem to affect outcomes of anterior circulation large vessel occlusion stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02419794.\n            <\/jats:p>\n          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