{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:49:58Z","timestamp":1775285398609,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The size of the saccular intracranial aneurysm (IA) has been used as the primary indicator for rupture risk. We investigated at which size IAs that rupture did so, and whether this size has significantly changed over time.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients treated for ruptured IAs were identified from the Aneurysm Database of the Tampere University Hospital. The size of the IA at the time of rupture was measured from computed tomographic angiography or digital subtraction angiography made to diagnose the aneurysm. Data for the clinical risk factors for rupture were collected from the patient's medical records.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Of the 2545 patients with ruptured intracranial aneurysms (IAs) admitted, the size of the ruptured IA could be determined for 76% (1925 of 2545). Fifty\u2010one percent (984 of 1925) of the studied IAs ruptured at a size &lt;7 mm. Both the mean and the median size of the IA at rupture had a downward trend from 1989 to 1997 (median decrease from 10\u00a0mm to 6\u00a0mm) but have remained relatively constant since. Forty\u2010six percent (881 of 1925) of the patients with a ruptured IA were not known to have any lifestyle\u2010related aneurysmal subarachnoid hemorrhage risk factor. Of the IAs that ruptured small, 35% were located in the\u00a0anterior communicating artery and 14% in other small intracranial arteries.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Small size should not be used to exclude unruptured IAs from prophylactic treatment. The observation that the size at which IAs rupture has previously decreased, suggesting a change in relative importance of risk factors or characteristics of a contemporary patient population compared with older cohorts.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.121.000193","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T04:47:50Z","timestamp":1650343670000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Size at Which Aneurysms Rupture: A Hospital\u2010Based Retrospective Cohort From 3 Decades"],"prefix":"10.1161","volume":"2","author":[{"given":"Jeremias","family":"Tarkiainen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milla","family":"Kelahaara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Pyysalo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Ronkainen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-950X","authenticated-orcid":false,"given":"Juhana","family":"Fr\u00f6sen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70143-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-302068"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112114"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70263-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001891"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005318"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1056\/NEJMoa1113260","article-title":"The natural course of unruptured cerebral aneurysms in a Japanese cohort","volume":"366","author":"Japan Investigators UCAS","year":"2012","unstructured":"UCAS Japan Investigators, Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, Hashimoto N, Nakayama T, Sakai M, Teramoto A, et\u00a0al. 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