{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:29Z","timestamp":1787018129364,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Platelet Fc\u03b3RIIa amplifies platelet activation and, thus, increased expression identifies patients with increased platelet reactivity. Previous work has demonstrated that platelet Fc\u03b3RIIa can identify patients at high and low risk of subsequent cardiovascular events after myocardial infarction (MI). This study was designed to compare platelet expression of Fc\u03b3RIIa in patients with stroke and transient ischemic attack (TIA) with that in patients with a recent MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients were enrolled based on an admitting diagnosis of stroke\/TIA, and the discharge diagnosis was used to categorize patients into stroke\/TIA (n=99) and other causes of neurologic dysfunction (hemorrhagic, trauma, toxic, and seizure; n=14). Patients with stroke\/TIA were divided into embolic (both cardioembolic and thromboembolic; n=32) and not embolic causes (n=67). Results were compared with platelet Fc\u03b3RIIa expression in patients with recent MI from a previous study (n=197). Platelet expression of Fc\u03b3RIIa (molecules of Fc\u03b3RIIa\/platelet) was quantified with the use of flow cytometry. Results are mean\u00b1SD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Platelet expression of Fc\u03b3RIIa was similar in patients with ischemic (both embolic and nonembolic) stroke\/TIA (11\u00a0332\u00b14127), embolic (11\u00a0204\u00b13889) and nonembolic (11\u00a0393\u00b14263) causes, and MI (11\u00a0479\u00b12405). Patients with other causes of neurologic dysfunction had modestly but not significantly lower platelet expression of Fc\u03b3RIIa (9389\u00b12883;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Platelet expression of Fc\u03b3RIIa was similar in patients with stroke\/TIA and recent MI. These results support future studies designed to determine whether platelet Fc\u03b3RIIa expression can discriminate risk of subsequent stroke\/TIA and its potential use as a precision tool capable of guiding individualized treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.121.000201","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T22:58:28Z","timestamp":1646780308000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Platelet Fc\u03b3RIIa Expression in Ischemic Stroke: A Marker of Increased Platelet Reactivity"],"prefix":"10.1161","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-6870","authenticated-orcid":false,"given":"David J.","family":"Schneider","sequence":"first","affiliation":[{"name":"The University of 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