{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:37:02Z","timestamp":1764733022217,"version":"3.41.2"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Southeast Asia accounts for approximately 10% of stroke\u2010related mortalities worldwide, yet there are limited data regarding mechanical thrombectomy (MT) outcomes in this region. PROSPR\u2010SEA (Post\u2010Market Registry of Stroke Patients Treated With Medtronic Neurothrombectomy Devices to Collect Real\u2010World Data in Southeast Asia) assessed post\u2010market clinical outcomes of MT using the Solitaire Revascularization Device in southeast Asia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">PROSPR\u2010SEA is a prospective, multicenter, nonrandomized, observational registry of patients who underwent MT using Solitaire as first line treatment at 1 of 10 centers in Vietnam, Thailand, and Singapore between January 2018 and July 2019. The primary end point was functional independence (modified Rankin scale 0\u20132) at 90\u00a0days. Safety end points included symptomatic intracerebral hemorrhage, emboli in new territory at 24\u00a0hours, and all\u2010cause mortality at 90\u00a0days. Secondary end points were successful revascularization (modified thrombolysis in cerebral infarction \u22652b), workflow metrics, National Institutes of Health Stroke Scale score at discharge, and patient disposition at 90 days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 183 patients (64.9\u00b113.7, 49.7% [91\/183] female) were included in the study and underwent MT; 79.2% (145\/183) had occlusions in the middle cerebral artery. Median baseline National Institutes of Health Stroke Scale was 15.0 (range 1\u201331) and median baseline Alberta Stroke Program Early CT Score was 8.0 (range 0\u201310). Functional independence at 90\u00a0days was achieved in 62.2% (112\/180). Mean puncture\u2010to\u2010revascularization time was 53.3\u00b153.9 minutes, and mean onset\u2010to\u2010revascularization time was 330.0\u00b1110.4 minutes. Revascularization was successful in 94.0% (172\/183) of patients. Median National Institutes of Health Stroke Scale improved at discharge (\u22128.0, range \u221222, 25) and 90\u00a0days (\u221213.0, range \u221222, 0). Within 24 hours, symptomatic intracerebral hemorrhage occurred in 7.7% (14\/183) and emboli in new territory in 3.3% (6\/183). At 90\u00a0days, the all\u2010cause mortality rate was 7.7% (14\/183). Most patients were discharged to home by 90 days (84.1%, 154\/183).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">PROSPR\u2010SEA demonstrated high rates of positive functional outcomes and procedural success with a low mortality rate and indicates that the technical and clinical outcomes of landmark MT trials using Solitaire as the first\u2010line device are reproducible in real\u2010world southeast Asian settings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.121.000318","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:26:32Z","timestamp":1696357592000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Post\u2010Market Registry of Stroke Patients Treated With Medtronic Neurothrombectomy Devices in Southeast Asia: PROSPR\u2010SEA"],"prefix":"10.1161","volume":"3","author":[{"given":"Huy Thang","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Cerebrovascular Disease The People of 115 Hospital Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Duy","family":"Ton","sequence":"additional","affiliation":[{"name":"Stroke Center Bach Mai Hospital Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dang Luu","family":"Vu","sequence":"additional","affiliation":[{"name":"Stroke Center Bach Mai Hospital Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anchalee","family":"Churojana","sequence":"additional","affiliation":[{"name":"Siriaj Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchai","family":"Nilanont","sequence":"additional","affiliation":[{"name":"Siriaj Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirintara (Pongpech) Singhara Na","family":"Ayudya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deidre Anne","family":"De Silva","sequence":"additional","affiliation":[{"name":"Stroke Center Singapore General Hospital Campus National Neuroscience Institute Singapore Singapore"},{"name":"Department of Medicine Division of Neurology National University Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston Lim Eng","family":"Hoe","sequence":"additional","affiliation":[{"name":"Stroke Center Singapore General Hospital Campus National Neuroscience Institute Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8548-4844","authenticated-orcid":false,"given":"Truong Le","family":"Van","sequence":"additional","affiliation":[{"name":"108 Military Central Hospital Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Thong","family":"Pham","sequence":"additional","affiliation":[{"name":"Stroke Center Bach Mai Hospital Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanaboon","family":"Worakijthamrongchai","sequence":"additional","affiliation":[{"name":"Neurological Institute of Thailand Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quoc Tuan","family":"Tran","sequence":"additional","affiliation":[{"name":"HCMC University Medical Center Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond Chee Seong","family":"Seet","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Neurology National University Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wickly","family":"Lee","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30034-1"},{"key":"e_1_3_2_3_2","unstructured":"Neurovascular interventions \u2013 global analysis and market forecasts. 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