{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:28:13Z","timestamp":1772695693868,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It remains unclear whether intravenous thrombolysis (IVT) influences the incidence of the first pass effect (FPE) in patients with acute large vessel occlusion treated with mechanical thrombectomy (MT). Therefore, this study investigated the effects of IVT on FPE in patients treated with MT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This is a post hoc analysis of the SKIP (Direct Mechanical Thrombectomy in Acute LVO Stroke) study, which was an investigator\u2010initiated, multicenter, randomized, open\u2010label clinical trial performed in 23 hospital networks in Japan from January 1, 2017, to July 31, 2019. Among 204 patients, 24 were excluded because they did not undergo MT. Patients treated with MT alone were compared with those treated with MT+IVT for the incidence of FPE (achieving a modified treatment in cerebral ischemia score of 2c or 3 after the first MT pass). Additional subgroup analyses were performed to investigate factors more closely related to the association between IVT and FPE.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among the 180 patients, 91 were treated with MT alone and 89 were treated with MT+IVT. FPE was achieved in 56 patients (31.1%). The incidence of FPE was significantly higher in patients treated with MT+IVT than in those treated with MT alone (39.3% versus 23.0%, respectively;\n              <jats:italic>P<\/jats:italic>\n              =0.02). In the subgroup analyses, IVT markedly increased FPE in female patients and tended to increase FPE in patients with first\u2010segment middle cerebral artery distal occlusion and onset to hospital arrival time &gt;100 minutes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">IVT using alteplase increased the incidence of FPE in Japanese patients with acute ischemic stroke treated with MT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">: Trial registration umin.ac.jp\/ctr identifier: UMIN000021488<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.122.000577","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T13:25:35Z","timestamp":1689081935000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous Thrombolysis Increases the First Pass Effect for Large Vessel Occlusion Treated With Mechanical Thrombectomy"],"prefix":"10.1161","volume":"3","author":[{"given":"Yuki","family":"Kamiya","sequence":"first","affiliation":[{"name":"Department of Endovascular Neurosurgery Toranomon Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Nippon Medical School Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Kuriki,","sequence":"additional","affiliation":[{"name":"Department of Neurology Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Mizuma","sequence":"additional","affiliation":[{"name":"Department of Neurology Showa University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataro","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery Toranomon Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Matsumaru","sequence":"additional","affiliation":[{"name":"Division of Stroke Prevention and Treatment Department of Neurosurgery Faculty of Medicine University of Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Nippon Medical School Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the SKIP study Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319832140"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029830"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020315"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025148"},{"key":"e_1_3_2_8_2","first-page":"1","article-title":"Factors influencing recanalization after mechanical thrombectomy with first\u2010pass effect for acute ischemic stroke: a systematic review and meta\u2010analysis","volume":"12","author":"Bai X","year":"2021","unstructured":"Bai X, Zhang X, Wang J, Zhang Y, Dmytriw AA, Wang T, Xu R, Ma Y, Li L, Feng Y, et\u00a0al. 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J Am Heart Assoc. 2019;8:1\u201315.","journal-title":"J Am Heart Assoc"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6074"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014294"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23522"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019840932"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.594333"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.212358"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001123"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23523"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107727"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00537-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00564-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000257304.21967.ba"},{"key":"e_1_3_2_24_2","first-page":"1","article-title":"Asymptomatic intracranial hemorrhage is associated with poor outcomes after mechanical thrombectomy for large vessel occlusion","volume":"2","author":"Suzuki K","year":"2022","unstructured":"Suzuki K, Matsumaru Y, Takeuchi M, Morimoto M, Kanazawa R, Takayama Y, Kamiya Y, Shigeta K, Okubo S, Hayakawa M, et\u00a0al. Asymptomatic intracranial hemorrhage is associated with poor outcomes after mechanical thrombectomy for large vessel occlusion. 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