{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:28:02Z","timestamp":1790972882084,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with white matter disease (WMD) \u2013 a key marker of cerebral small vessel disease \u2013 may have less brain reserve to cope with ischemic injury. The relationship of WMD to functional recovery after endovascular thrombectomy is uncertain. We aim to explore the association between WMD and functional outcome, assessed at multiple time\u2010points postendovascular thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this post hoc analysis, we analyzed noncontrast computed tomography\u2010imaging from the ESCAPE\u2010NA1 (Safety and Efficacy of Nerinetide [NA\u20101] in Subjects Undergoing Endovascular Thrombectomy for Stroke) trial and assessed WMD by using the total Fazekas\u2010score (score range: 0\u20136). The primary outcome was repeated measurements of the modified Rankin scale (mRS) scores (i.e., day\u20105\/discharge, day\u201030, and day\u201090). Secondary outcome measures were the ordinal\u2010mRS at 90\u2010days, 90\u2010day\u2010mRS0\u20132, and 90\u2010day\u2010mortality. Mixed\u2010linear and binary\/ordinal logistic regressions were performed, adjusting for age, sex, baseline National Institutes of Health Stroke Scale, cortical atrophy, chronic infarctions, stroke laterality, follow\u2010up infarct volume, and alteplase\u2013nerinetide interaction. Sensitivity analyses were done including only those patients for whom magnetic resonance imaging was available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We included 1102 patients with noncontrast computed tomography (median age 71, interquartile range: 61\u201380; median National Institutes of Health Stroke Scale 17, interquartile range: 12\u201321). The median total Fazekas\u2010score was 1(interquartile range: 0\u20132). Out of 1202 patients, 566 had follow\u2010up magnetic resonance imaging. We observed heterogeneity in functional recovery with varying degrees of WMD\u2010burden (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Patients with Fazekas=3\u20136 fared worse at every time\u2010point after endovascular thrombectomy, compared with patients with Fazekas=0\u20131. At 30\u2010days, the adjusted difference of the mean mRS=0.47; 95% CI, 0.22\u20130.72 and at 90\u2010days: adjusted difference=0.60 (95% CI, 0.36\u20130.85). Higher WMD\u2010burdens were also associated with worse 90\u2010day mRS (adjusted common odds ratio for Fazekas=3\u20136 versus 0\u20131: 1.42; 95% CI, 1.03\u20131.96). Similar results were found in magnetic resonance imaging\u2010only sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with more WMD showed worse functional recovery after endovascular thrombectomy, compared with patients without WMD, even after adjusting for age and chronic disease markers like atrophy and chronic infarctions. These data may further help inform treatment expectations and recovery\u2010related planning, by using simple visual ratings on routinely acquired noncontrast computed tomography.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.122.000734","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:43:01Z","timestamp":1679298181000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Association of White Matter Disease With Functional Recovery and 90\u2010Day Outcome After EVT: Beyond Chronological Age"],"prefix":"10.1161","volume":"3","author":[{"given":"Faysal","family":"Benali","sequence":"first","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"Maastricht University Medical Center+ (MUMC+)","place":["Maastricht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Fladt","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"University Hospital Basel","place":["Basel, Switzerland"]},{"name":"University of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaporn","family":"Jaroenngarmsamer","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouzi","family":"Bala","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishita","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Alhabli","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Ospel","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"University Hospital Basel","place":["Basel, Switzerland"]},{"name":"University of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tymianski","sequence":"additional","affiliation":[{"name":"NoNO","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"University of Calgary","place":["Calgary, Canada"]},{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Goyal","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"University of Calgary","place":["Calgary, Canada"]},{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind","family":"Ganesh","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]},{"name":"University of Calgary","place":["Calgary, Canada"]},{"name":"University of Calgary Cumming School of Medicine","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ESCAPE\u2010NA1 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/SVIN.121.000167"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.06.023"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1161\/STROKEAHA.116.014096","article-title":"Leukoaraiosis, cerebral hemorrhage, and outcome after intravenous thrombolysis for acute ischemic stroke: a meta\u2010analysis (v1)","volume":"47","author":"Charidimou A","year":"2016","unstructured":"Charidimou A, Pasi M, Fiorelli M, Shams S, von Kummer R, Pantoni L, Rost N. 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