{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:31:05Z","timestamp":1786739465705,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Acute ischemic stroke attributed to basilar artery occlusion (BAO) results in high rates of death and significant morbidity. Endovascular thrombectomy an effective treatment for BAO, but imaging parameters that predict a favorable response to thrombectomy are not well defined. We determined which imaging parameters were associated with poor outcome in patients with BAO treated by thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We performed a retrospective cohort study of patients with BAO who underwent thrombectomy at multiple international stroke centers. All patients underwent computed tomography or magnetic resonance perfusion imaging before treatment. Clinical and imaging variables were measured and correlated to poor functional outcomes (modified Rankin scale score \u22654) after thrombectomy. Imaging variables included the following: Critical Area Perfusion Score, Posterior Circulation Alberta Stroke Program Early Computed Tomography Score, ischemic core volume (30% cerebral blood flow on computed tomography perfusion or diffusion\u2010weighted imaging), and volume of time to maximum &gt;10\u00a0seconds. Clinical and imaging variables associated with poor functional outcome were assessed by a multivariable binary logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 102 patients were included in the study. Median patient age was 66.5\u00a0years (interquartile range [IQR], 55\u201378), median presentation National Institutes of Health Stroke Scale score was 14 (IQR, 7\u201323), and the median time from last seen normal was 4\u00a0hours (IQR, 1:52\u20139:20). Patient age (odds ratio [OR], 1.37 per 5\u2010year increment [95% CI, 1.08\u20131.72]; P=0.008), presentation National Institutes of Health Stroke Scale score (OR, 1.11 [95% CI, 1.04\u20131.18]; P=0.001), successful reperfusion after thrombectomy (OR, 0.03 [95% CI, 0.003\u20130.25]; P=0.002), Posterior Circulation Alberta Stroke Program Early Computed Tomography Score \u22646 (OR, 11.40 [95% CI, 1.73\u201375]; P=0.011), and Critical Area Perfusion Score &gt;3 (OR, 26.22 [95% CI, 1.07\u2013642];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.045) independently predicted poor outcome after BAO thrombectomy. Ischemic core volume (30% cerebral blood flow) and volume of time to maximum &gt;10\u00a0seconds did not predict poor outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">Age, National Institutes of Health Stroke Scale presentation, unsuccessful reperfusion, Critical Area Perfusion Score &gt;3, and Posterior Circulation Alberta Stroke Program Early Computed Tomography Score \u22646 are independently associated with poor outcome after BAO thrombectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.122.000767","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:44:06Z","timestamp":1674891846000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Imaging Factors Associated With Poor Outcome in Patients With Basilar Artery Occlusion Treated With Endovascular Thrombectomy"],"prefix":"10.1161","volume":"3","author":[{"given":"Jeremy J.","family":"Heit","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mlynash","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo W.","family":"Cereda","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland","place":["Lugano, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Yuen","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten G.","family":"Lansberg","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bianco","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland","place":["Lugano, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soren","family":"Christensen","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid Y.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Kansas University Medical Center","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Hinduja","sequence":"additional","affiliation":[{"name":"The Ohio State Wexner Medical Center","place":["Columbus, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seena","family":"Dehkharghani","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam E.","family":"Goldman\u2010Yassen","sequence":"additional","affiliation":[{"name":"Emory University Hospital","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Li\u2010Chun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Taipei Medical University Hospital","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u2010Victor","family":"Giurgiutiu","sequence":"additional","affiliation":[{"name":"Augusta University","place":["Augusta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Gibson","sequence":"additional","affiliation":[{"name":"Ascension Columbia St. Mary's Hospital","place":["Milwaukee, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Carrera","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences","place":["Geneva, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fana","family":"Alemseged","sequence":"additional","affiliation":[{"name":"University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias D.","family":"Faizy","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg\u2010Eppendorf","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fiehler","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg\u2010Eppendorf","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pileggi","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland","place":["Lugano, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030297"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30395-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207576"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206317"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.511162"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017744465"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032924"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26272"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4727"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012089"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987316629889"},{"key":"e_1_3_1_17_2","first-page":"545","article-title":"Occlusion of the basilar artery. A review with 17 personal cases (author's transl)","volume":"137","author":"Labauge R","year":"1981","unstructured":"Labauge R, Pages M, Marty\u2010Double C, Blard JM, Boukobza M, Salvaing P. [Occlusion of the basilar artery. A review with 17 personal cases (author's transl)]. Rev Neurol (Paris). 1981;137:545\u2010571.","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014516"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2210737"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213701"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212793"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214300"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.05.101"},{"issue":"8","key":"e_1_3_1_26_2","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1177\/0271678X20982395","article-title":"Normative distribution of posterior circulation tissue time\u2010to\u2010maximum: effects of anatomic variation, tracer kinetics, and implications for patient selection in posterior circulation ischemic stroke","volume":"41","author":"Goldman\u2010Yassen AE","year":"2021","unstructured":"Goldman\u2010Yassen AE, Straka M, Uhouse M, Dehkharghani S. Normative distribution of posterior circulation tissue time\u2010to\u2010maximum: effects of anatomic variation, tracer kinetics, and implications for patient selection in posterior circulation ischemic stroke. J Cereb Blood Flow Metab. 2021;41(8):1912\u20101923. https:\/\/doi.org\/10.1177\/0271678\u00d720982395","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010962"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031371"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486690"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.10.008"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02517-6"}],"container-title":["Stroke: Vascular and Interventional Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/SVIN.122.000767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:07:26Z","timestamp":1774616846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/SVIN.122.000767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1161\/SVIN.122.000767"],"URL":"https:\/\/doi.org\/10.1161\/svin.122.000767","relation":{},"ISSN":["2694-5746"],"issn-type":[{"value":"2694-5746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e000767"}}