{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:11:49Z","timestamp":1774620709106,"version":"3.50.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The authors present the long\u2010term (4\u00a0year) results of a first\u2010in\u2010man, single\u2010center case series with the Nautilus Intrasaccular System for the embolization of wide\u2010neck intracranial aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">From February 2018 to July 2018, the authors enrolled 5 patients into a first\u2010in\u2010human study of the Nautilus device. After treatment, patients underwent 6\u00a0months with digital subtraction angiography and 3\u00a0years with magnetic resonance angiography according to institutional standard of care. Occlusion rates were core\u2010laboratory adjudicated for the digital subtraction angiography and independently assessed by a neurointerventionalist not part of the care team for the magnetic resonance angiography. Neurological outcome (modified Ranking scale score) was evaluated at 24\u00a0hours, 7\u00a0days, 6\u00a0months, and 1, 2, 3, and 4\u00a0years, and adverse events were collected during the first 6\u00a0months post\u00a0treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Five patients with unruptured, wide\u2010necked aneurysms were treated and followed up for 4\u00a0years. Aneurysm locations included basilar bifurcation (2 of 5), internal carotid artery terminus (1 of 5), superior cerebellar artery (1 of 5), and the anterior communicating artery (1 of 5). The average aneurysm size was 7.6\u00a0mm and the average neck diameter was 5.2\u00a0mm. Immediate complete and near\u2010complete occlusion (Raymond\u2013Roy classification class I and II) was achieved in 80% (4 of 5) of the aneurysms. Occlusion results improved at 6\u00a0months and remained stable at 3\u00a0years, without retreatment (Raymond\u2013Roy classification class I 80%, class I and II 100%). All patients maintained good neurological outcome at all follow\u2010ups (modified Ranking scale 0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">This initial clinical experience provides early evidence of the long\u2010term safety and effectiveness of the new intrasaccular neck bridging device, Nautilus. The Nautilus appears to add a simple, safe, and effective option and solution to the coil embolization of the wide\u2010neck aneurysm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.122.000770","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:51:07Z","timestamp":1679298667000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Four\u2010Year Follow\u2010Up on the First\u2010in\u2010Human Experience With Nautilus Intrasaccular System Assisted Coiling for Unruptured Intracranial Aneurysms"],"prefix":"10.1161","volume":"3","author":[{"given":"Nobuyuki","family":"Sakai","sequence":"first","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Funatsu","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Okuda","sequence":"additional","affiliation":[{"name":"Kyushu University","place":["Fikuoka, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiya","family":"Beppu","sequence":"additional","affiliation":[{"name":"Hyogo medical college","place":["Nishinomiya, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Adachi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazufumi","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Tani","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemitsu","family":"Adachi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuhi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Kyoto, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Fukumitsu","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyoshi","family":"Shigematsu","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fneur.2014.00041","article-title":"Balloons and stents in the endovascular treatment of cerebral aneurysms: vascular anatomy remodeled","volume":"5","author":"Piotin M","year":"2014","unstructured":"Piotin M, Blanc R. 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