{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:19:47Z","timestamp":1761311987440,"version":"3.41.2"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The effectiveness of endovascular thrombectomy (EVT) has been proven even in patients with large cerebral infarction in the early time window. However, the association of the time course with the treatment effect is unknown. The aim of this analysis was to evaluate the influence of the time course from stroke onset to reperfusion on the therapeutic effect of EVT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">The subjects were patients with occlusion of large vessels and sizable strokes on imaging (Alberta Stroke Program Early Computed Tomographic score 3\u20135) in RESCUE\u2013Japan LIMIT (Recovery by Endovascular Salvage for Cerebral Ultra\u2010Acute Embolism\u2013Japan Large Ischemic Core Trial), a multicenter, randomized, clinical open\u2010label trial of EVT versus medical care alone. In the current analysis, the clinical and time course characteristics associated with a favorable outcome (modified Rankin scale [mRS] score of 0\u20132 and 0\u20133 at 90 days) were examined in patients treated with EVT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The analysis included 71 patients (median age, 77 years; median National Institutes of Health Stroke Scale score on admission, 21). Occlusion sites were the internal carotid artery (48%), proximal segment of the middle cerebral artery (72%) and tandem lesions (20%). Of these patients, 23 (32%) had an mRS score of 0 to 3 and 12 (17%) had an mRS score of 0 to 2 at 90 days. In multivariate analysis, there were independent associations of onset to reperfusion time (odds ratio [OR], 0.991 [95% CI, 0.984\u20130.999];\n              <jats:italic>P<\/jats:italic>\n              =0.01) and puncture to reperfusion time (OR , 0.952 [95% CI, 0.917\u20130.988];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) with an mRS score of 0 to 3 at 90 days, and puncture to reperfusion time (OR, 0.930 [95% CI, 0.872\u20130.991];\n              <jats:italic>P<\/jats:italic>\n              =0.004) with an mRS score of 0 to 2 at 90 days.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Earlier reperfusion was related to a favorable outcome in patients with acute large\u2010vessel occlusion with a large ischemic region. Onset to reperfusion time and especially puncture to reperfusion time were independently associated with a favorable outcome. These results suggest the importance of timing and uninterrupted EVT in this patient population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.123.000880","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T15:32:08Z","timestamp":1690212728000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Time Course of Thrombectomy and Outcomes for Large Acute Ischemic Region: RESCUE\u2013Japan LIMIT Subanalysis"],"prefix":"10.1161","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-2412","authenticated-orcid":false,"given":"Hideyuki","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Yamaguchi University Graduate School of Medicine Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery 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