{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:15:06Z","timestamp":1786979706570,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Procedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. We aimed to compare the safety profile of low\u2010dose intravenous cangrelor versus dual oral antiplatelet therapy (DAPT) loading in patients with acute cervical tandem lesions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 \u03bcg\/kg followed by an infusion of 2\u00a0\u03bcg\/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in\u2010stent thrombosis. Inverse probability of treatment weighting matching was used to reduce confounding.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              From 691 patients, we included 195 patients, 30 of whom received intravenous cangrelor and 165 DAPT. The DAPT regimens were aspirin+clopidogrel (93.3%) or aspirin+ticagrelor (6.6%). After inverse probability of treatment weighting, the patients treated with cangrelor were not at greater odds of symptomatic intracranial hemorrhage (odds ratio [OR], 1.30 [95% CI, 0.09\u201317.3];\n              <jats:italic>P<\/jats:italic>\n              =0.837), symptomatic intracranial hemorrhage\u2013parenchymal hematoma type 2 (OR, 0.54 [95% CI, 0.05\u20134.98];\n              <jats:italic>P<\/jats:italic>\n              =0.589), or petechial hemorrhage (OR, 1.11 [95% CI, 0.38\u20133.28];\n              <jats:italic>P<\/jats:italic>\n              =0.836). Similarly, the rate of in\u2010stent thrombosis was not significantly different between the 2 groups (1.8% versus 0%;\n              <jats:italic>P<\/jats:italic>\n              =0.911).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Cangrelor at the half dose of the myocardial infarction protocol showed a similar safety profile compared with the commonly used DAPT loading protocols in patients with acute tandem lesions. Further studies with larger samples are warranted to elucidate the safety of antiplatelet therapy in tandem lesions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.123.001020","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:25:56Z","timestamp":1696357556000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study"],"prefix":"10.1161","volume":"3","author":[{"given":"Aaron","family":"Rodriguez\u2010Calienes","sequence":"first","affiliation":[{"name":"Department of Neurology University of Iowa Hospitals and Clinics Iowa City IA"},{"name":"Neuroscience Clinical Effectiveness and Public Health Research Group Universidad Cient\u00edfica del Sur Lima 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Neurology and Brain Repair University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer M.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Siegler","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute Cooper University Hospital Camden NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology UT Health McGovern Medical School Houston 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