{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:53:58Z","timestamp":1753887238756,"version":"3.41.2"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The optimal management of patients with symptomatic isolated internal carotid artery (ICA) occlusion is unknown. We aimed to assess whether endovascular treatment (EVT) compared with standard medical care was associated with improved functional outcomes in patients with acute symptomatic isolated intracranial ICA occlusion without involvement of the middle or anterior cerebral artery, that is, ICA\u2010I occlusion. Additionally, we aimed to compare ICA\u2010I with ICA\u2010L\/T occlusion, which involves themiddle and anterior cerebral artery, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed data from the highly effective reperfusion evaluated in multiple endovascular stroke trials (HERMES) collaboration, which performed an individual patient data meta\u2010analysis of 7 randomized controlled trials conducted between 2010 and 2017 assessing the benefit of EVT compared to medical management in patients with anterior circulation large vessel occlusion. We assessed the association between EVT and 90\u2010day good functional outcome (modified Rankin scale scores 0\u20132), National Institutes of Health Stroke Scale scores at 24 hours, symptomatic intracranial hemorrhage rates and mortality in patients with ICA\u2010I and ICA\u2010L\/T occlusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We included 442 patients with intracranial ICA occlusion, of whom 38 (8.6%) had ICA\u2010I occlusion. In the ICA\u2010I group, the median age [interquartile range] was 69.5 [61.7\u201379.5] years, 42.1% were male, and median baseline National Institutes of Health Stroke Scale was 17 [15\u201320]. Compared with standard medical care alone, EVT resulted in higher good outcome rates in patients with ICA\u2010I (42.9% versus 25%;\n              <jats:italic>P<\/jats:italic>\n              =0.296) and ICA\u2010L\/T occlusion (32.5% versus 14.4%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and significant improvement in National Institutes of Health Stroke Scale scores at 24 hours. Mortality and symptomatic intracranial hemorrhage rates were similar between the treatment groups for both occlusion types.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A minority of patients with intracranial carotid occlusion presented with ICA\u2010I occlusion in the HERMES population. EVT in patients with ICA\u2010I occlusion and moderate\u2010to\u2010severe deficit was safe and tended to be similarly effective as compared to patients with ICA\u2010L\/T occlusion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.123.001025","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:12:27Z","timestamp":1696003947000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Endovascular Treatment in HERMES Patients With Isolated Occlusion of the Intracranial Internal Carotid Artery"],"prefix":"10.1161","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-0025","authenticated-orcid":false,"given":"Daniel P.O.","family":"Kaiser","sequence":"first","affiliation":[{"name":"Institute of Neuroradiology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"Dresden Neurovascular Center, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh N.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Interventional Neurology\/Neuroradiology Boston Medical Center Boston University School of Medicine MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce C.V.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neurology Melbourne Brain Centre Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Los Angeles Medical Center Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diederik W.J.","family":"Dippel","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute Foothills Medical Center University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.L.M.","family":"Majoie","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers location AMC Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott B.","family":"Brown","sequence":"additional","affiliation":[{"name":"BRIGHT Research Partners, Inc Mooresville NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Melbourne Hospital University of Melbourne Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes C.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"Dresden Neurovascular Center, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Bracard","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University of Lorraine and University Hospital of Nancy Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Guillemin","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology University of Lorraine and University Hospital of Nancy Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor G.","family":"Jovin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center Stroke Institute Presbyterian University Hospital PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith W.","family":"Muir","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Psychology, University of Glasgow Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"White","sequence":"additional","affiliation":[{"name":"Translation and Clinical Research Institute Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Schoene","sequence":"additional","affiliation":[{"name":"Dresden Neurovascular Center, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute Foothills Medical Center University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayank","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute Foothills Medical Center University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Puetz","sequence":"additional","affiliation":[{"name":"Dresden Neurovascular Center, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the HERMES Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30242-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04735-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02550-5"},{"key":"e_1_3_2_6_2","article-title":"Endovascular therapy versus medical therapy for acute stroke attributable to isolated cervical internal carotid artery occlusion without intracranial large vessel 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