{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:15:18Z","timestamp":1781036118533,"version":"3.54.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Thrombectomy is well\u2010established management for acute ischemic stroke involving large vessel occlusion. However. the potential efficacy of thrombectomy for isolated posterior cerebral artery occlusion remains limited. The study aims to evaluate the benefits of thrombectomy for isolated posterior cerebral artery occlusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We searched PubMed, Cochrane, and Embase for articles published until September 2023. The primary outcome was good functional outcome at 3 months. The secondary outcomes included excellent functional outcome at 3 months and early neurological improvement. The safety outcomes were symptomatic intracerebral hemorrhage, and mortality at 3 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Seven retrospective studies involving 2560 patients with isolated posterior cerebral artery occlusion were included (876 patients receiving thrombectomy). The odds ratio (OR) of good functional outcome at 3 months was 0.93 (95% CI, 0.68\u20131.28) between 2 groups. The OR of excellent functional outcome (OR 1.23; 95% CI 0.92\u20131.64) and early neurological improvement (OR 1.82; 95% CI 0.97\u20133.40) were not different between the 2 groups. Compared with patients with best medical management, those with thrombectomy demonstrated a significantly increased risk of mortality (OR 1.81; 95% CI 1.24\u20132.65), whereas the risk of symptomatic intracerebral hemorrhage (OR 2.033; 95% CI 0.996\u20134.148) did not show an increase. Additionally, the results of trial sequential analysis indicated all outcomes were inconclusive.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Thrombectomy stands as an available procedure for patients with isolated posterior cerebral artery occlusion; however, it shows no notable benefits in reducing symptomatic intracerebral hemorrhage risk or enhancing function and may raise mortality compared with standard medical management. Further randomized controlled trials are necessary to yield more conclusive evidence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.123.001084","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T13:31:52Z","timestamp":1707571912000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Is Thrombectomy Worth It for Isolated Posterior Cerebral Artery Occlusion? Meta\u2010Analysis and Trial Sequential Analysis"],"prefix":"10.1161","volume":"4","author":[{"given":"Hong\u2010Jie","family":"Jhou","sequence":"first","affiliation":[{"name":"Department of Neurology Changhua Christian Hospital Changhua Taiwan"},{"name":"School of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho\u2010Hao","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Medicine Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chi","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-6417","authenticated-orcid":false,"given":"Po\u2010Huang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-812X","authenticated-orcid":false,"given":"Li\u2010Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Neurology Chang Bing Show Chwan Memorial Hospital Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03384.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.028956"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000333610","article-title":"Posterior cerebral artery territory infarctions","volume":"30","author":"Cereda C","year":"2012","unstructured":"Cereda C, Carrera E. 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