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This trial investigates the efficacy and safety of low\u2010dose methylprednisolone (2 mg\/kg IV for 3 days) as adjunctive therapy for patients with acute ischemic stroke undergoing endovascular therapy within 24\u00a0hours from symptom onset.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">The MARVEL (Methylprednisolone as Adjunctive Therapy for Acute Large Vessel Occlusion: A Randomized Double\u2010Blind, Placebo\u2010Controlled Trial in Patients Undergoing Endovascular Therapy) trial is an investigator\u2010initiated, prospective, randomized, double\u2010blind, placebo\u2010controlled multicenter clinical trial. Up to 1672 eligible patients with anterior circulation large\u2010vessel occlusion stroke presenting within 24 hours from symptom onset are planned to be consecutively randomized to receive methylprednisolone or placebo in a 1:1 ratio across 82 stroke centers in China.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The primary outcome is the ordinal shift in the modified Rankin scale score at 90 days. Secondary outcomes include 90\u2010day functional independence (modified Rankin scale score, 0\u20132). The primary safety end points include mortality rate at 90 days and symptomatic intracerebral hemorrhage within 48 hours of endovascular therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">The MARVEL trial will provide evidence of the efficacy and safety of low\u2010dose methylprednisolone as adjunctive therapy for patients with anterior circulation large\u2010vessel occlusion stroke undergoing endovascular therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.123.001090","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:14:10Z","timestamp":1706368450000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["MARVEL: A Randomized Double\u2010Blind, Placebo\u2010Controlled Trial in Patients Undergoing Endovascular Therapy: Study Rationale and 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