{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:10:54Z","timestamp":1781244654155,"version":"3.54.1"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">First described over 4 decades ago as a diffuse form of arteriovenous malformation, cerebral proliferative angiopathy (CPA) is now categorized as a distinct vascular anomaly. Unlike arteriovenous malformation, which typically forms a well\u2010developed vascular nidus with feeder vessels and distinct venous outflow, CPA is the product of disorganized angiogenesis; thus, it lacks a true nidus. Its characteristic cycle of ischemia, angiogenesis, and aberrant perfusion can lead to abnormal blood flow patterns that characterize the disease. Treatment of CPA has historically relied on conservative management (antiepileptic drugs), and efforts to effectively manage this pathology have been hindered by an incomplete understanding of its natural history.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">A systematic search of 4 databases was performed. The following variables were extracted when present: study sample size, year of publication, age(s) of patient(s), sex, presenting signs and symptoms, neurological deficits (pre\u2010 and postoperative), type of intervention, average follow\u2010up time, and patient\u2010reported as well as functional outcomes at last follow\u2010up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Following the search and screen, 48 studies reporting 105 CPA cases remained eligible for inclusion. These studies consisted of 41 case reports, 6 case series, and 1 retrospective cohort study. The most common modality used in treatment of CPA was conservative management (53.4%). The second most common treatment modality was endovascular embolization (36.9%). The least common treatment modality was gamma knife radiosurgery, which was used in only 2 patients. Eleven patients experienced intracranial hemorrhage as a complication of CPA; 10 of the 11 patients underwent decompressive craniectomy. Finally, revascularization surgery was reportedly used in 5 patients (4.9%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Although there remains a dearth of studies reporting CPA, several clearly defined traits have been identified that characterize this pathology and distinguish it from arteriovenous malformation. Nonetheless, the verdict has not yet been reached regarding the effectiveness of surgical interventions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.123.001186","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T19:11:38Z","timestamp":1707246698000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Proliferative Angiopathy: A Systematic Review"],"prefix":"10.1161","volume":"4","author":[{"given":"Nolan J.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010Irvine Orange CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian V.","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010Irvine Orange CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Ehresman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redi","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1887-3980","authenticated-orcid":false,"given":"Michael T.","family":"Lawton","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"863","article-title":"Diffuse arteriovenous malformations: a clinical, radiological, and pathological description","volume":"31","author":"Chin LS","year":"1992","unstructured":"Chin LS, Raffel C, Gonzalez\u2010Gomez I, Giannotta SL, McComb JG. Diffuse arteriovenous malformations: a clinical, radiological, and pathological description. Neurosurgery. 1992;31:863\u2010868; discussion 868\u20139.","journal-title":"Neurosurgery"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.11.FOCUS18529"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.493080"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.6.PEDS1170"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.JNS132793"},{"key":"e_1_3_2_7_2","article-title":"Chapter 7: systematic reviews of etiology and risk","author":"Moola S","year":"2020","unstructured":"Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R. Chapter 7: systematic reviews of etiology and risk. JBI. 2020.","journal-title":"JBI"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1007\/s00330-001-1293-y","article-title":"MR perfusion imaging in a case of cerebral proliferative angiopathy","volume":"12","author":"Ducreux D","year":"2002","unstructured":"Ducreux D, Petit\u2010Lacour MC, Marsot\u2010Dupuch K, Bittoun J, Lasjaunias P. MR perfusion imaging in a case of cerebral proliferative angiopathy. Eur Radiol. 2002;12:2717\u20102722.","journal-title":"Eur Radiol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/jnnp.2009.183277","article-title":"Neurological picture. Cerebral proliferative angiopathy associated with haemangioma of the face and tongue","volume":"81","author":"Hong KS","year":"2010","unstructured":"Hong KS, Lee JI, Hong SC. Neurological picture. Cerebral proliferative angiopathy associated with haemangioma of the face and tongue. J Neurol Neurosurg Psychiatry. 2010;81:36\u201037.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2010000200027"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.10.PEDS10388"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/1591019918787265","article-title":"Recurrent periventricular hemorrhage in cerebral proliferative angiopathy: case report","volume":"24","author":"Maekawa H","year":"2018","unstructured":"Maekawa H, Terada A, Ishiguro T, Komiyama M, Lenck S, Renieri L, Krings T. Recurrent periventricular hemorrhage in cerebral proliferative angiopathy: case report. Interv Neuroradiol. 2018;24:713\u2010717.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2011-010027"},{"key":"e_1_3_2_14_2","article-title":"Acute hemiparesis in a child as a presenting symptom of hemispheric cerebral proliferative angiopathy","volume":"2013","author":"Gold JJ","year":"2013","unstructured":"Gold JJ, Crawford JR. Acute hemiparesis in a child as a presenting symptom of hemispheric cerebral proliferative angiopathy. Case Rep Neurol Med. 2013;2013:920859.","journal-title":"Case Rep Neurol Med"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjab620","article-title":"Diffuse proliferative cerebral angiopathy: a case report and literature review on a very rare and misdiagnosed entity","volume":"2022","author":"Panthi S","year":"2022","unstructured":"Panthi S, Khanal N, Poudel S, Bhandari S, Khatiwada P, Acharya R, Bhattarai R, Bhattarai B, Khanal S. Diffuse proliferative cerebral angiopathy: a case report and literature review on a very rare and misdiagnosed entity. J Surg Case Rep. 2022;2022:rjab620.","journal-title":"J Surg Case Rep"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.11.021"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4103\/0972-2327.120477","article-title":"Cerebral proliferative angiopathy: a rare clinical entity with peculiar angiographic features","volume":"16","author":"Srivastava T","year":"2013","unstructured":"Srivastava T, Mathur T, Jain R, Sannegowda RB. Cerebral proliferative angiopathy: a rare clinical entity with peculiar angiographic features. Ann Indian Acad Neurol. 2013;16:674\u2010675.","journal-title":"Ann Indian Acad Neurol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4103\/1793-5482.161185","article-title":"Infratentorial hemorrhagic cerebral proliferative angiopathy: a rare presentation of a rare disease","volume":"10","author":"Kumar S","year":"2015","unstructured":"Kumar S, Sharma M, Srivastava T, Sinha VD. Infratentorial hemorrhagic cerebral proliferative angiopathy: a rare presentation of a rare disease. Asian J Neurosurg. 2015;10:240\u2010242.","journal-title":"Asian J Neurosurg"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3941\/jrcr.v9i9.2402","article-title":"Diffuse proliferative cerebral angiopathy: a case report and review of the literature","volume":"9","author":"Rohit Goh PS","year":"2015","unstructured":"Rohit Goh PS. Diffuse proliferative cerebral angiopathy: a case report and review of the literature. J Radiol Case Rep. 2015;9:1\u201010.","journal-title":"J Radiol Case Rep"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1591019915609784","article-title":"Cerebral proliferative angiopathy: clinical, angiographic features and literature review","volume":"22","author":"Liu P","year":"2016","unstructured":"Liu P, Lv X, Lv M, Li Y. Cerebral proliferative angiopathy: clinical, angiographic features and literature review. Interv Neuroradiol. 2016;22:101\u2010107.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.07.042"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1971400916656486"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2016.09.012"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000459629","article-title":"Cerebral proliferative angiopathy in a child","volume":"52","author":"Puerta P","year":"2017","unstructured":"Puerta P, Guill\u00e9n A, Muchart J, Gonz\u00e1lez V, Ferrer E. Cerebral proliferative angiopathy in a child. Pediatr Neurosurg. 2017;52:214\u2010216.","journal-title":"Pediatr Neurosurg"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/159101991201800310","article-title":"Fatal hemorrhage in cerebral proliferative angiopathy","volume":"18","author":"Maekawa H","year":"2012","unstructured":"Maekawa H, Tanaka M, Hadeishi H. Fatal hemorrhage in cerebral proliferative angiopathy. Interv Neuroradiol. 2012;18:309\u2010313.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0038-1642604","article-title":"Cerebral proliferative angiopathy: case report","volume":"37","author":"Gatto L","year":"2018","unstructured":"Gatto L, Brisson R, Demartini Z Jr, Koppe G, Rocha C Jr.. Cerebral proliferative angiopathy: case report. Arq Bras Neurocir. 2018;37:131\u2010133.","journal-title":"Arq Bras Neurocir"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/1591019918761640","article-title":"Targeted endovascular treatment of haemorrhagic posterior fossa proliferative angiopathy","volume":"24","author":"Giragani S","year":"2018","unstructured":"Giragani S, Pavunesan SK, Balasubramaniam A. Targeted endovascular treatment of haemorrhagic posterior fossa proliferative angiopathy. Interv Neuroradiol. 2018;24:440\u2010443.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.05.038"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.03.029"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00381-019-04313-x","article-title":"Pediatric cerebral proliferative angiopathy presenting infratentorial hemorrhage","volume":"36","author":"Beniwal M","year":"2020","unstructured":"Beniwal M, Kandregula S, Aravind, Rao KVLN, Vikas V, Srinivas D. Pediatric cerebral proliferative angiopathy presenting infratentorial hemorrhage. Childs Nerv Syst. 2020;36:429\u2010433.","journal-title":"Childs Nerv Syst"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02688697.2021.2013437","article-title":"Volume staged stereotactic radiosurgery and endovascular embolization in the treatment of cerebral proliferative angiopathy: lessons learned","author":"Brake A","year":"2021","unstructured":"Brake A, Fry L, Chatley KS, Peterson J, Stepp T, Wang F, Ebersole K. Volume staged stereotactic radiosurgery and endovascular embolization in the treatment of cerebral proliferative angiopathy: lessons learned. Br J Neurosurg. 2021:1\u20105.","journal-title":"Br J Neurosurg"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2021.101184"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i20.5730"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420950484"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.107011"},{"key":"e_1_3_2_36_2","article-title":"Removal of malformation in cerebral proliferative angiopathy: illustrative case","volume":"1","author":"Choi GY","year":"2021","unstructured":"Choi GY, Choi HJ, Jeon JP, Yang JS, Kang SH, Cho YJ. Removal of malformation in cerebral proliferative angiopathy: illustrative case. J Neurosurg Case Lessons. 2021;1:CASE2095.","journal-title":"J Neurosurg Case Lessons"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.05.096"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000527559","article-title":"Multiple endovascular treatments for hemorrhagic cerebral proliferative angiopathy: a case report","volume":"14","author":"Shomura K","year":"2022","unstructured":"Shomura K, Kamide T, Misaki K, Tsutsui T, Nambu I, Uchiyama N, Nakada M. Multiple endovascular treatments for hemorrhagic cerebral proliferative angiopathy: a case report. Case Rep Neurol. 2022;14:433\u2010440.","journal-title":"Case Rep Neurol"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00381-021-05181-0","article-title":"Hemorrhagic cerebral proliferative angiopathy in two pediatric patients: case reports","volume":"38","author":"Ochoa A","year":"2022","unstructured":"Ochoa A, Mantese B, Requejo F. Hemorrhagic cerebral proliferative angiopathy in two pediatric patients: case reports. Childs Nerv Syst. 2022;38:789\u2010794.","journal-title":"Childs Nerv Syst"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.03.104"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/19714009211042884"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","DOI":"10.3171\/CASE22437","article-title":"Long\u2010term hemodynamic changes in cerebral proliferative angiopathy presenting with intracranial hemorrhage: illustrative case","volume":"5","author":"Saito T","year":"2023","unstructured":"Saito T, Harada K, Kajihara M, Sanbongi C, Fukuyama K. Long\u2010term hemodynamic changes in cerebral proliferative angiopathy presenting with intracranial hemorrhage: illustrative case. J Neurosurg Case Lessons. 2023;5:CASE22437. https:\/\/doi.org\/10.3171\/CASE22437","journal-title":"J Neurosurg Case Lessons"},{"issue":"2","key":"e_1_3_2_43_2","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.230058","article-title":"Diffuse cerebral proliferative angiopathy","volume":"308","author":"Lakhani D","year":"2023","unstructured":"Lakhani D, Boo S. Diffuse cerebral proliferative angiopathy. Radiology. 2023;308(2):e230058.","journal-title":"Radiology"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5334\/jbsr.3247","article-title":"Cerebral proliferative angiopathy in a child, five years after an intraventricular hemorrhage and negative catheter angiography","volume":"107","author":"Singfer U","year":"2023","unstructured":"Singfer U, Baert E, Defreyne L. Cerebral proliferative angiopathy in a child, five years after an intraventricular hemorrhage and negative catheter angiography. J Belg Soc Radiol. 2023;107:55.","journal-title":"J Belg Soc Radiol"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/19418744231180046"},{"issue":"1","key":"e_1_3_2_46_2","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjab620","article-title":"Diffuse proliferative cerebral angiopathy: a case report and literature review on a very rare and misdiagnosed entity","volume":"2022","author":"Panthi S","year":"2022","unstructured":"Panthi S, Khanal N, Poudel S, Bhandari S, Khatiwada P, Acharya R, Bhattarai R, Bhattarai B, Khanal S. Diffuse proliferative cerebral angiopathy: a case report and literature review on a very rare and misdiagnosed entity. J Surg Case Rep. 2022;2022(1):rjab620.","journal-title":"J Surg Case Rep"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-0039-3401329","article-title":"Cerebral proliferative angiopathy: an uncommon and misdiagnosed entity","volume":"4","author":"Tiwari S","year":"2020","unstructured":"Tiwari S, Garg PK, Khera PS, Babu S, Sureka B, Yadav T. Cerebral proliferative angiopathy: an uncommon and misdiagnosed entity. J Clin Interv Radiol Isvir. 2020;4:107\u2010110.","journal-title":"J Clin Interv Radiol Isvir"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0b013e318296f22b"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"082","DOI":"10.1055\/s-0035-1547393","article-title":"Cerebral proliferative angiopathy\u2014description of a rare clinical entity","volume":"34","author":"Biasi PR","year":"2015","unstructured":"Biasi PR, Almeida T, Espanhol R, Brunet M, Crusius PS, Mallmann AB, Seibert CA, Crusius MU, Carazzo CA, Crusius CU. Cerebral proliferative angiopathy\u2014description of a rare clinical entity. Arq Bras Neurocir. 2015;34:082\u2010085.","journal-title":"Arq Bras Neurocir"},{"key":"e_1_3_2_50_2","first-page":"192","article-title":"Cerebral proliferative angiopathy: a rare type of cerebral vascular malformation","volume":"21","author":"Tse JCH","year":"2018","unstructured":"Tse JCH, Lee TF, Lai BMH, Luk SY, Leung KW, Wong WC. Cerebral proliferative angiopathy: a rare type of cerebral vascular malformation. Hong Kong J Radiol. 2018;21:192\u2010195.","journal-title":"Hong Kong J Radiol"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2022.101663"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e3181ff1e79"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-240468"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000946"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12233"}],"container-title":["Stroke: Vascular and Interventional Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/SVIN.123.001186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T14:58:31Z","timestamp":1720623511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/SVIN.123.001186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1161\/SVIN.123.001186"],"URL":"https:\/\/doi.org\/10.1161\/svin.123.001186","relation":{},"ISSN":["2694-5746"],"issn-type":[{"value":"2694-5746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001186"}}