{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:29:22Z","timestamp":1773476962100,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec id=\"svi212925-sec-0010\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hemodynamic stress is linked to the development of intracranial aneurysms (IAs) and may be influenced by anatomic variation of intracranial arteries. We assessed diameters and bifurcation angles of intracranial arteries forming the circle of Willis in a cohort of individuals screened for the presence of IAs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"svi212925-sec-0020\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Individuals with and without IAs identified at screening with magnetic resonance angiography were compared. Diameters and bifurcation angles of the following arteries were measured using semiautomatic methods: A1 and A2 segments of the anterior cerebral artery, M1 and M2 segments of the middle cerebral artery, P1 segments of the posterior cerebral artery, posterior communicating artery (Pcom), internal carotid artery, vertebral artery, and basilar artery. We employed univariate general linear models to assess group differences. This included subgroup comparisons between individuals with IAs at specific locations and matched controls, and comparisons on group level between individuals with and without IAs, corrected for age and sex.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"svi212925-sec-0030\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In 94 of the 1049 individuals (9.0%) included, IAs were detected. Individuals with middle cerebral artery IAs had wider ipsilateral M2\u2013M2 bifurcation angles compared with controls (121\u00b125\u00b0 versus 97\u00b119\u00b0;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.01). Individuals with anterior communicating artery IAs showed smaller angles for the A1\u2013A2 bifurcation (106\u00b116\u00b0 versus 120\u00b117\u00b0;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u00a0=\u00a00.02), while those with Pcom IAs had wider Pcom\u2013C7 bifurcation angles (147\u00b114\u00b0 versus 127\u00b117\u00b0;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u00a0=\u00a00.02) and smaller diameters below the ipsilateral internal carotid artery top (2.86\u00b10.36 mm versus 3.10\u00b10.33 mm;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              \u00a0=\u00a00.03) compared with controls.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"svi212925-sec-0040\" xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">We found associations between wider M2\u2013M2 bifurcation angles or narrower A1\u2013A2 bifurcation angles and IA presence, consistent with prior literature. Moreover, we uncovered previously unexplored associations, including wider Pcom\u2013C7 bifurcation angles and smaller internal carotid artery diameters in individuals with Pcom IAs. Future research should explore the potential of these markers in predicting IAs in at\u2010risk populations during follow\u2010up screenings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/svin.124.001299","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T07:18:54Z","timestamp":1714720734000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Anatomical Markers Associated With the Presence of Intracranial Aneurysms in Individuals Screened for Aneurysms"],"prefix":"10.1161","volume":"4","author":[{"given":"Iris N.","family":"Vos","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick J.","family":"van Tuijl","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, Netherlands"]},{"name":"University Medical Center Utrecht","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liselore A.","family":"Mensing","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Netherlands"]},{"name":"Utrecht University","place":["Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud E. 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E.","family":"Rinkel","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Netherlands"]},{"name":"Utrecht University","place":["Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo J.","family":"Kuijf","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaco J. 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