{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:28Z","timestamp":1787018128976,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec id=\"svi212941-sec-0010\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Large vessel occlusion secondary to underlying intracranial atherosclerotic disease (ICAD\u2010LVO) has an estimated prevalence of 7% to30%. There is a large variation in the use of intracranial rescue stenting in interventional practice. We aimed to characterize the frequency and characteristics of intracranial rescue stenting in a large cohort of endovascular therapy for stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"svi212941-sec-0020\" xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Systematic Evaluation of Patients Treated With Stroke Devices for Acute Ischemic Stroke (STRATIS) angiography core lab adjudicated the location of the occlusion, hyperdense vessel sign on initial imaging, the use of angioplasty and stenting, and imaging outcomes following endovascular therapy. Underlying cause of stroke was categorized into intracranial atherosclerosis, cardioembolic, and other subtypes. Statistical analyses examined the relationship between intracranial rescue stenting and imaging outcomes including intracranial hemorrhage, and arterial reperfusion using expanded Thrombolysis in Cerebral Infarction reperfusion score in patients with ICAD\u2010LVO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"svi212941-sec-0030\" xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 978 patients with LVO stroke undergoing endovascular therapy, 91 (9.3%) patients had ICAD\u2010LVO. Baseline hyperdense vessel sign was observed among 44 (62.7%) with ICAD versus 178 (68.2%) with cardioembolic LVO (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =\n0.4). Final successful reperfusion (expanded Thrombolysis in Cerebral Infarction 2b50 or more) was significantly lower among ICAD\u2010LVO as compared with cardioembolic\u2010LVO (74.2% versus 87.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007). Intracranial rescue stenting was used among 14\/665 (2.1%) of patients with LVO (5 ICA terminus, 7 M1 middle cerebral artery, 1 M2 middle cerebral artery, 1 proximal basilar artery). Among 14 intracranial rescue stenting cases, 5\/70 (7.1%) belonged to the ICAD group, 3\/261 (1.1%) cardioembolic group, and 6\/334 (1.8%) in other or undetermined group. Successful reperfusion following rescue stenting was achieved in all cases with ICAD\u2010LVO. Among ICAD\u2010LVO, the rate of 24 hours symptomatic intracranial hemorrhage was 0% with acute intracranial stenting versus 7.7% in the nonstenting subgroup.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"svi212941-sec-0040\" xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">In STRATIS, nearly 1 of every 11 thrombectomies were performed in patients with underlying ICAD, among whom 7.1% underwent rescue intracranial stenting concomitant with thrombectomy. Acute intracranial stenting as rescue therapy in ICAD\u2010LVO was associated with favorable angiographic outcomes and low symptomatic hemorrhage rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.124.001378","type":"journal-article","created":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T08:51:47Z","timestamp":1720342307000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and Angiographic Outcomes of Rescue Intracranial Stenting in Large Vessel Occlusion Following Stroke Thrombectomy \u2013 STRATIS"],"prefix":"10.1161","volume":"5","author":[{"given":"Hamidreza","family":"Saber","sequence":"first","affiliation":[{"name":"University of Texas at Austin","place":["Austin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Froehler","sequence":"additional","affiliation":[{"name":"Vanderbilt University, Medical Center","place":["Nashville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama O.","family":"Zaidat","sequence":"additional","affiliation":[{"name":"Mercy St. Vincent Hospital","place":["Toledo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aziz\u2010Sultan","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Klucznik","sequence":"additional","affiliation":[{"name":"Methodist Hospital","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"UCLA","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerses","family":"Sanossian","sequence":"additional","affiliation":[{"name":"University of South California","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Frank R.","family":"Hellinger","sequence":"additional","affiliation":[{"name":"Florida Hospital","place":["Orlando"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileep R.","family":"Yavagal","sequence":"additional","affiliation":[{"name":"University of Miami\/Jackson Memorial Hospital","place":["Miami"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom L.","family":"Yao","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute","place":["Louisville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Jahan","sequence":"additional","affiliation":[{"name":"UCLA","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"Emory University School of Med\/Grady Memorial Hospital","place":["Atlanta"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center","place":["Pittsburgh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils H.","family":"Mueller\u2010Kronast","sequence":"additional","affiliation":[{"name":"Delray Medical Ctr\/Tenet South Florida","place":["Delray Beach"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-8736","authenticated-orcid":false,"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"UCLA","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the STRATIS Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.1.JNS172350"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022327"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013489"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010667"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-020-00934-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02262-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-014877"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/1591019918763380","article-title":"Primary angioplasty and stenting may be superior to thrombectomy for acute atherosclerotic large\u2010artery occlusion","volume":"24","author":"Yang D","year":"2018","unstructured":"Yang D, Lin M, Wang S, Wang H, Hao Y, Zi W, Lv P, Zheng D, Xiao G, Xu G, et\u00a0al. Primary angioplasty and stenting may be superior to thrombectomy for acute atherosclerotic large\u2010artery occlusion. Interv Neuroradiol. 2018;24:412\u2010420.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016456"},{"key":"e_1_3_2_14_2","unstructured":"Systematic Evaluation of Patients Treated With Stroke Devices for Acute Ischemic Stroke (STRATIS) Registry \u2013 Full Text View \u2013 ClinicalTrials.gov [Internet]. Accessed May 1 2024. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02239640"},{"key":"e_1_3_2_15_2","unstructured":"Strengthening the reporting of observational studies in epidemiology. Accessed May 1 2024. https:\/\/www.strobe\u2010statement.org\/"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02262-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486246"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020195"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/SVIN.122.000510"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/SVIN.123.001142"}],"container-title":["Stroke: Vascular and Interventional Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/SVIN.124.001378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T23:21:47Z","timestamp":1749597707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/SVIN.124.001378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1161\/SVIN.124.001378"],"URL":"https:\/\/doi.org\/10.1161\/svin.124.001378","relation":{},"ISSN":["2694-5746"],"issn-type":[{"value":"2694-5746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e001378"}}