{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:51Z","timestamp":1792512951106,"version":"4.5.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p xml:lang=\"en\">There is limited information on systemic blood pressure goals and variability before and during mechanical thrombectomy and how it affects outcomes in large vessel ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p xml:lang=\"en\">A longitudinal cohort study of patients with acute ischemic stroke and large vessel occlusion who underwent thrombectomy at a comprehensive stroke center in southwestern Colombia (January 2017\u2013January 2023). Two groups were defined: group H (hypotension before thrombectomy, defined as &gt;30 mmHg systolic blood pressure drop between arrival and anesthesia induction) and no hypotension (NH) group. Primary outcomes included functional status (modified Rankin Scale score, 0\u20132 favorable; 3\u20136 unfavorable) and mortality (modified Rankin scale score = 6) at discharge and 90\u2010day follow\u2010up. Inverse probability weighting was used to reduce confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 167 patients (44.3% female), median age 66 (interquartile range, 53\u201376), underwent thrombectomy. Admission National Institutes of Health Stroke Scale score and Alberta Stroke Program Early Computed Tomography Score were similar (16.5 versus 16; Alberta Stroke Program Early Computed Tomography Score 9 in both). Thrombolysis was used in 45.4% (H: 23.3% versus NH: 22.1%). Door\u2010to\u2010needle time: 56 minutes versus 47 minutes; door\u2010to\u2010groin: 138 minutes versus 129.5 minutes. Procedure duration was longer in H (100 minutes versus 85 minutes). Successful reperfusion was not significantly different (modified Thrombolysis in Cerebral Infarction\u22652b) 73.05% (H: 76.6%, NH: 70%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.29). Unfavorable modified Rankin scale score at discharge: H: 70.1%, NH: 68.9% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.86). Mortality at discharge: H: 32.5%, NH: 16.7% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.2); at 90 days: H: 37.7%, NH: 18.9% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) with inverse probability weighting analysis showing higher mortality in H both at discharge (odds ratio [OR] = 2.16, 95% CI: 0.93\u20135.04,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.07) and 90 days (OR = 2.93, 95% CI: 1.25\u20136.86,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) only the latter with statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p xml:lang=\"en\">Hypotension before thrombectomy in large vessel occlusion stroke was associated with increased 90\u2010day mortality. Worse functional outcomes were also observed, though not statistically significant. Early blood pressure control during anesthetic induction may improve prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.001789","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T02:39:49Z","timestamp":1761187189000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Periprocedural Hypotension and Functional Outcomes in Ischemic Stroke Patients Undergoing Mechanical Thrombectomy"],"prefix":"10.1161","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-6064","authenticated-orcid":false,"given":"Maria","family":"Zuluaga","sequence":"first","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan David","family":"Tasc\u00f3n\u2010Romero","sequence":"additional","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime A.","family":"Ortiz\u2010Villegas","sequence":"additional","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder","family":"Moreno","sequence":"additional","affiliation":[{"name":"Universidad de la Sabana","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mej\u00eda\u2010Qui\u00f1ones","sequence":"additional","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]},{"name":"Fundaci\u00f3n Valle del Lili","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Llanos\u2010Leyton","sequence":"additional","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]},{"name":"Fundaci\u00f3n Valle del Lili","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vargas","sequence":"additional","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Folleco","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Amaya","sequence":"additional","affiliation":[{"name":"Universidad Icesi","place":["Cali, Colombia"]},{"name":"Fundaci\u00f3n Valle del Lili","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/STROKEAHA.122.038466","article-title":"Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke","volume":"54","author":"Nie X","year":"2022","unstructured":"Nie X, Leng X, Miao Z, Fisher M, Liu L. 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