{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:29:53Z","timestamp":1793316593968,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p xml:lang=\"en\">Middle meningeal artery embolization with a liquid embolic is a minimally invasive adjunctive endovascular treatment for chronic subdural hematoma (cSDH). TRUFILL n\u2010butyl cyanoacrylate Liquid Embolic System provides a possible option for middle meningeal artery embolization. The aim of this study is to evaluate safety\/effectiveness of TRUFILL n\u2010butyl cyanoacrylate versus standard\u2010of\u2010care alone for middle meningeal artery embolization in patients with cSDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p xml:lang=\"en\">MEMBRANE (Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL n\u2010BCA) is a prospective, multicenter, open\u2010label, randomized\u2010controlled trial enrolling \u223c376 adults at \u223c35 sites in the United States and China. Site physicians will determine whether participants will undergo surgery or nonsurgical management. After demonstrating cSDH stability, participants will be randomized within the surgical or nonsurgical cohort to receive standard\u2010of\u2010care with\/without TRUFILL n\u2010butyl cyanoacrylate middle meningeal artery embolization, with follow\u2010ups at 1, 3, 6, and 12 months post procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p xml:lang=\"en\">Primary effectiveness end point is the occurrence of residual or re\u2010accumulation of hematoma (&gt;10 mm) at 6\u00a0months (assessed by independent imaging core laboratory) or reoperation\/surgical procedure on the hematoma within 6 months. The primary safety end point is the occurrence of all adverse events through 6 months. Other end points include good functional outcome at 3 months (modified Rankin scale score: 0\u20132 or no worsening from baseline if baseline modified Rankin scale score \u22653); change in hematoma volume; complete cSDH resolution; development of acute component or new cSDH; requirement for cSDH surgery; death, stroke, myocardial infarction, or thromboembolic complications; new\u2010onset seizures; change in modified Rankin Scale\/Markwalder Grading Scale scores; quality of life; and healthcare resource use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p xml:lang=\"en\">Results will provide valuable information on the safety\/effectiveness of TRUFILL n\u2010butyl cyanoacrylate as a minimally invasive standalone or adjunct treatment for cSDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration Information<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicatrials.gov\">http:\/\/clinicatrials.gov<\/jats:ext-link>\n                      ; Identifier: NCT04816591\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.001828","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:54:05Z","timestamp":1758084845000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Middle Meningeal Artery Embolization with n\u2010Butyl Cyanoacrylate for the Treatment of Subdural Hematomas: The MEMBRANE Study Design"],"prefix":"10.1161","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-8205","authenticated-orcid":false,"given":"Christopher P.","family":"Kellner","sequence":"first","affiliation":[{"name":"Department of Neurosurgery","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-7005","authenticated-orcid":false,"given":"Fawaz","family":"Al\u2010Mufti","sequence":"additional","affiliation":[{"name":"Westchester Medical Center","place":["Valhalla"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-2498","authenticated-orcid":false,"given":"Rishi","family":"Gupta","sequence":"additional","affiliation":[{"name":"WellStar Health System","place":["Marietta"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-0763","authenticated-orcid":false,"given":"Brian T.","family":"Jankowitz","sequence":"additional","affiliation":[{"name":"JFK University Medical Center","place":["Edison"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Starke","sequence":"additional","affiliation":[{"name":"University of Miami, Jackson Memorial Hospital","place":["Miami"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-4805","authenticated-orcid":false,"given":"Ansaar T.","family":"Rai","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.JNS141550"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2176\/nmc.32.207","article-title":"Chronic subdural hematoma in elderly people: present status on Awaji Island and epidemiological prospect","volume":"32","author":"Kudo H","year":"1992","unstructured":"Kudo H, Kuwamura K, Izawa I, Sawa H, Tamaki N. 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