{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:11:12Z","timestamp":1788891072806,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Hemorrhagic transformation (HT) after endovascular thrombectomy (EVT) is associated with worse neurological outcomes. We sought to identify clinical and demographic factors associated with HT and HT subtypes after EVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients with anterior circulation large vessel occlusion who underwent first-pass EVT using different thrombectomy devices were enrolled in a global multicenter prospective registry. Baseline clinical characteristics were compared between individuals with and without HT and across HT subtypes 24 hours after EVT. Multivariable logistic regression models were used to determine risk factors associated with HT and HT subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The study cohort comprised 1453 patients. Imaging evidence of HT occurred in 40% of patients, of whom 3.2% had symptomatic HT. In a multivariable regression analysis, diabetes (odds ratio [OR], 1.47 [95% CI, 1.09\u20131.99];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), National Institutes of Health Stroke Scale score of 16 to 19 (OR, 1.45 [95% CI, 1.09\u20131.94];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), National Institutes of Health Stroke Scale score \u226520 (OR, 1.98 [95% CI, 1.56\u20132.50];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001), Alberta Stroke Program Early Computed Tomography Score \u22658 (OR, 0.31 [95% CI, 0.24\u20130.39];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001), and elevated baseline serum glucose (OR, 1.56 [95% CI, 1.23\u20131.98];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0003) were independent risk factors for HT. Atrial fibrillation (OR, 0.75 [95% CI, 0.58\u20130.96];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02) was a protective factor against HT. Baseline Alberta Stroke Program Early Computed Tomography Score &lt;8, elevated baseline serum glucose, and higher baseline National Institutes of Health Stroke Scale scores were independent predictors of hemorrhagic infarction-1 and hemorrhagic infarction-2. Diabetes was significantly associated with hemorrhagic infarction-2, and Alberta Stroke Program Early Computed Tomography Score &lt;8 was significantly associated with subarachnoid hemorrhage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Given that certain risk factors are associated with specific subtypes of HT, our analysis demonstrates the importance of not only reporting symptomatic HT but also classifying HT into subtypes in clinical trials. Identifying risk factors associated with HT subtypes may improve prognostic accuracy and guide post-EVT monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03845491.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.001899","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:00:16Z","timestamp":1784624416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Demographic Factors Associated With Hemorrhagic Transformation Subtypes After Endovascular Thrombectomy for Acute Ischemic Stroke"],"prefix":"10.1161","volume":"6","clinical-trial-number":[{"clinical-trial-number":"nct03845491","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Nicole","family":"Khezri","sequence":"first","affiliation":[{"name":"Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles (N.K., M.K.L., D.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-3930","authenticated-orcid":true,"given":"Marie K.","family":"Luff","sequence":"additional","affiliation":[{"name":"Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles (N.K., M.K.L., D.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Miralb\u00e9s","sequence":"additional","affiliation":[{"name":"Neuroradiology, Hospital Son Espases, Mallorca, Spain (S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0322-5824","authenticated-orcid":true,"given":"Bharath","family":"Naravetla","sequence":"additional","affiliation":[{"name":"Interventional Neurology, McLaren Regional Medical Center, Flint, MI (B.N.)."},{"name":"Interventional Neurology, McLaren Regional Medical Center, Macomb, MI (B.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Spiotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-9734","authenticated-orcid":true,"given":"Christian","family":"Loehr","sequence":"additional","affiliation":[{"name":"Radiology and Neuroradiology, Klinikum Vest Recklinghausen, Recklinghausen, Germany (C.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-4712","authenticated-orcid":true,"given":"Mario","family":"Mart\u00ednez-Gald\u00e1mez","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology\/Endovascular Neurosurgery, Hospital Cl\u00ednico Universitario de Valladolid, Spain (M.M.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-5161","authenticated-orcid":true,"given":"Ryan","family":"McTaggart","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology, Rhode Island Hospital, Providence (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-2798","authenticated-orcid":true,"given":"Luc","family":"Defreyne","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology, Ghent University Hospital, Belgium 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