{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:34:31Z","timestamp":1782567271336,"version":"3.54.5"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p xml:lang=\"en\">Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) are commonly prescribed for the management of type 2 diabetes, and recent studies have highlighted their neuroprotective and anti\u2010inflammatory properties. However, their influence on clinical outcomes in patients undergoing endovascular treatment for unruptured intracranial aneurysms remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This retrospective cohort study utilized the TriNetX database to identify patients with type 2 diabetes (\n                      <jats:italic toggle=\"yes\">International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      [\n                      <jats:italic toggle=\"yes\">ICD\u201010<\/jats:italic>\n                      ]: E11) and unruptured intracranial aneurysms (\n                      <jats:italic toggle=\"yes\">ICD\u201010<\/jats:italic>\n                      : I67.1). Patients were categorized based on the use of GLP\u20101RAs. The outcomes included overall survival, poor functional outcome, new subarachnoid hemorrhage, and hydrocephalus. The propensity score matching method was applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 6824 patients met the inclusion criteria, with 447 patients in each group following propensity score matching. No statistically significant differences were observed in short\u2010 and mid\u2010term mortality between GLP\u20101RAs users and non\u2010users. However, long\u2010term mortality was significantly lower in the GLP\u20101 group (odds ratio 0.58, 95% CI 0.36\u20130.94). Furthermore, GLP\u20101RAs users demonstrated significantly reduced risks of poor functional outcomes (odds ratio 0.37, 95% CI 0.21\u20130.66), new subarachnoid hemorrhage (odds ratio 0.39, 95% CI 0.27\u20130.56), and hydrocephalus (odds ratio 0.57, 95% CI 0.33\u20130.97) at 3 months, with similar trends persisting in mid\u2010 and long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p xml:lang=\"en\">Use of GLP\u20101RAs in patients with unruptured intracranial aneurysms treated via endovascular intervention is associated with improved long\u2010term survival and reduced risks of subarachnoid hemorrhage, hydrocephalus, and poor functional outcomes. These findings suggest a potential therapeutic benefit beyond glycemic control. Prospective studies are needed to validate these results and explore their implications for clinical decision\u2010making in aneurysm treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.001933","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:58:11Z","timestamp":1758009491000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["GLP\u20101 Receptor Agonists and Clinical Outcomes after Endovascular Treatment of Unruptured Aneurysms in Type 2 Diabetes"],"prefix":"10.1161","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-2144","authenticated-orcid":false,"given":"Pang\u2010Shuo","family":"Perng","sequence":"first","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"CHI St. Vincent North, Arkansas Neuroscience Institute","place":["Sherwood, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tsung","family":"Chuang","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010En","family":"Wong","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Kuang","family":"Wang","sequence":"additional","affiliation":[{"name":"E\u2010Da Hospital","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Yu","family":"Chi","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine","place":["Bronx"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Shun","family":"Lee","sequence":"additional","affiliation":[{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-7016","authenticated-orcid":false,"given":"Chih\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"name":"College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/jamaneurol.2018.4165","article-title":"Procedural clinical complications, case\u2010fatality risks, and risk factors in endovascular and neurosurgical treatment of unruptured intracranial aneurysms: a systematic review and meta\u2010analysis","volume":"76","author":"Algra AM","year":"2019","unstructured":"Algra AM, Lindgren A, Vergouwen MDI, Greving JP, van der Schaaf IC, van Doormaal TPC, Rinkel GJE. 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