{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:50:42Z","timestamp":1763610642386,"version":"3.45.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p xml:lang=\"en\">Approximately 20% of ischemic strokes in the United States result from carotid artery stenosis. Carotid artery stenting (CAS) can reduce stroke risk, but variability in poststenting health outcomes and their predictors is poorly understood. We examined the 30\u2010day post\u2010CAS health status and derived its most important predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Stenting and Angioplasty with Protection of Patients with High Risk for Endarterectomy (SAPPHIRE) Worldwide Registry measured preprocedural and 30\u2010day health status for patients undergoing transfemoral CAS using the 36\u2010item Short Form Survey Mental Component Summary and Physical Component Summary, EuroQoL 5\u2010Dimension Index Value, and Visual Analogue Scale. Random Forest models ranked 66 preprocedural candidate variables by relative importance (RI) in predicting 30\u2010day post\u2010CAS health status, stratified by patient symptomatic status. Variables with the highest relative importance were identified and used to develop predictive multivariable linear regression models, which were evaluated using R\u2010square (coefficient of determination) and root mean square error.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p xml:lang=\"en\">Health status was assessed using the 36\u2010item Short Form Survey in 3017 patients and EuroQoL 5\u2010Dimension in 3930 patients. Random forest models identified 9 key predictors of post\u2010CAS health status: preprocedural health status (RI 100%), Modified Rankin Scale score (RI 26.2%\u201376.5%), National Institutes of Health Stroke Scale score (RI 12.1%\u201328.0%), history of stroke (RI 9.2%\u201319.8%), congestive heart failure (RI 12.3%\u201319.7%), spinal immobility (RI 6.7%\u201331.0%), diabetes mellitus (RI 8.1%\u201332.9%), severe pulmonary disease\/chronic obstructive pulmonary disease (RI 13.8%\u201345.6%), and non\u2010Hispanic\/Latino ethnicity (RI 8.4%\u201332.4%). Multivariable linear regression models explained \u223c36%\u201361% of the health status variance, with 36\u2010item Short Form Survey models (R\u2010square = 36%\u201361%) outperforming EuroQoL 5\u2010Dimension models (R\u2010square 37%\u201344%) with regard to R\u2010square and visual fit of observed versus predicted values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p xml:lang=\"en\">We derived multivariable linear regression\u2010based prediction models that partially explained 30\u2010day post\u2010CAS health status outcomes. Preprocedural health status scores, stroke scale scores, and medical comorbidities may have utility in appropriately risk\u2010stratifying patients under consideration for CAS and should be considered when discussing health status benefits in pre\u2010CAS treatment shared decision\u2010making discussions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration Information<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study analyzed data from the SAPPHIRE Worldwide: Stenting and Angioplasty with Protection of Patients with High Risk for Endarterectomy trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>ClinicalTrials.gov ID<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      NCT00403078.URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT00403078\">https:\/\/clinicaltrials.gov\/study\/NCT00403078<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.001938","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:15:46Z","timestamp":1758867346000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Applying a Random Forest Approach in Predicting Health Status in Patients with Carotid Artery Stenosis 30 Days Post Stenting"],"prefix":"10.1161","volume":"5","author":[{"given":"Omar","family":"Qureshi","sequence":"first","affiliation":[{"name":"Yale University","place":["New Haven, USA"]},{"name":"Yale School of Medicine","place":["New Haven, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mena\u2010Hurtado","sequence":"additional","affiliation":[{"name":"Yale University","place":["New Haven, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Romain","sequence":"additional","affiliation":[{"name":"Yale University","place":["New Haven, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Cleman","sequence":"additional","affiliation":[{"name":"Yale University","place":["New Haven, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Callegari","sequence":"additional","affiliation":[{"name":"Yale University","place":["New Haven, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-6254","authenticated-orcid":false,"given":"Kim G.","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Yale University","place":["New Haven, USA"]},{"name":"Yale University","place":["New Haven, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_2_2_2","DOI":"10.1053\/j.semvascsurg.2021.02.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1212\/WNL.0000000000002354","article-title":"Recurrent stroke in symptomatic carotid stenosis awaiting revascularization: A pooled analysis","volume":"86","author":"Johansson E","year":"2016","unstructured":"Johansson E, Cuadrado\u2010Godia E, Hayden D, Bjellerup J, Ois A, Roquer J, Wester P, Kelly PJ, Recurrent stroke in symptomatic carotid stenosis awaiting revascularization: A pooled analysis. 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