{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:51:33Z","timestamp":1763610693457,"version":"3.45.0"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stroke\u2010associated hyperkinetic movements are most often linked to basal ganglia lesions, while cortical or insular involvement is rarely reported. Hemichorea is an uncommon manifestation of acute ischemic stroke and may pose diagnostic and therapeutic challenges. We report the case of an 81\u2010year\u2010old woman presenting with acute Broca\u2010type aphasia and left hemibody choreic movements. Initial computed tomography (CT)\/computed tomography angiography revealed an occlusion of the right M2 segment of the middle cerebral artery. Perfusion imaging showed a significant ischemic penumbra without established infarction. Mechanical thrombectomy, performed eight hours after symptom onset, achieved complete reperfusion (Thrombolysis in Cerebral Infarction grade 3). Within 24 hours, aphasia resolved, and hemichorea markedly improved, persisting only as mild distal movements at discharge and completely disappearing within weeks. Magnetic resonance imaging demonstrated a small acute ischemic lesion confined to the right insular region. This case highlights the role of corticalsubcortical motor networks beyond the basal ganglia in the pathogenesis of post\u2010stroke hyperkinetic movements. The insula, through its influence on temporalbasal ganglia pathways, may contribute to chorea generation. To our knowledge, this is the first reported case of hemichorea due to insular infarction successfully treated with thrombectomy, with complete clinical recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.002017","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T03:21:22Z","timestamp":1760584882000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Hemichorea as a Manifestation of Isolated Insular Infarction Successfully Treated with Mechanical Thrombectomy"],"prefix":"10.1161","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-3141","authenticated-orcid":false,"given":"Marina","family":"Romozzi","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","place":["Rome, Italy"]},{"name":"Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Tosto","sequence":"additional","affiliation":[{"name":"\u201cGiovanni Paolo II\u201d Hospital Lamezia Terme","place":["Catanzaro, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Garignano","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldobrando","family":"Broccolini","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","place":["Rome, Italy"]},{"name":"Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","place":["Rome, Italy"]},{"name":"Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105150","article-title":"Hemichorea as presentation of acute cortical ischemic stroke. case series and review of the literature","volume":"29","author":"Carbayo \u00c1","year":"2020","unstructured":"Carbayo \u00c1, Sarto J, Santana D, Compta Y, Urra X. Hemichorea as presentation of acute cortical ischemic stroke. case series and review of the literature. J Stroke Cerebrovasc Dis. 2020;29:105150.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"e_1_3_2_3_2","article-title":"Chorea as the first manifestation of cerebral infarction","volume":"12","author":"Hernandez Fustes OJ","year":"2020","unstructured":"Hernandez Fustes OJ, Puppi Munhoz R, Arteaga Rodriguez C, Hernandez Fustes OJ. Chorea as the first manifestation of cerebral infarction. Cureus. 2020;12:e7384.","journal-title":"Cureus"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-226035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1212\/WNL.0000000000008706","article-title":"Teaching Video NeuroImages: Acute hemichorea\u2010hemiballism reverted after IV thrombolysis","volume":"94","author":"Disserol C","year":"2020","unstructured":"Disserol C, Alencar B, Parmera J, Conforto AB, Pinto LF. Teaching Video NeuroImages: Acute hemichorea\u2010hemiballism reverted after IV thrombolysis. Neurology. 2020;94:e121\u2013e2.","journal-title":"Neurology"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12883-023-03230-6","article-title":"Hemichorea secondary to isolated temporal infarction with severe middle cerebral artery stenosis: a case report and review of literature","volume":"23","author":"Dong H","year":"2023","unstructured":"Dong H, Zhao J, Lee KY, Shen G. Hemichorea secondary to isolated temporal infarction with severe middle cerebral artery stenosis: a case report and review of literature. BMC Neurol. 2023;23:186.","journal-title":"BMC Neurol"}],"container-title":["Stroke: Vascular and Interventional Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/SVIN.125.002017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:39:21Z","timestamp":1763609961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/SVIN.125.002017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1161\/SVIN.125.002017"],"URL":"https:\/\/doi.org\/10.1161\/svin.125.002017","relation":{},"ISSN":["2694-5746"],"issn-type":[{"type":"electronic","value":"2694-5746"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002017"}}