{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:00:55Z","timestamp":1789880455881,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p xml:lang=\"en\">The benefit of endovascular thrombectomy (EVT) in patients with basilar artery occlusion and severe neurological deficits is well established. However, its effectiveness in those with mild\u2010to\u2010moderate deficits remains uncertain. This study compared outcomes of EVT(\u00b1intravenous thrombolysis [IVT]) versus IVT alone in patients with basilar artery occlusion and mild\u2010to\u2010moderate stroke severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p xml:lang=\"en\">We used data from the international multicenter EVA\u2010TRISP (Endovascular Treatment and Thrombolysis for Ischemic Stroke Patients) and TRISP (Thrombolysis for Ischemic Stroke Patients) collaboration. All patients with radiologically confirmed basilar artery occlusion, National Institutes of Health Stroke Scale score &lt;10, and a time to first treatment within 6 hours were included. Main outcomes of interest were favorable (functional) outcome (modified Rankin Scale [mRS] score 0\u20142), overall distribution of mRS, mortality at 3 months, and symptomatic intracranial hemorrhage. We applied binary logistic and ordinal regression using covariate adjustment and inverse probability of treatment weighting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 274 patients from 18 centers, 176 (64.3%) received EVT (mean age 68\u00b115 years, 38% female, median [interquartile range] National Institutes of Health Stroke Scale score 5 [3\u20148], 34% with bridging IVT) and 98 (35.8%) received IVT alone (mean age 70\u00b113 years, 43% female, median National Institutes of Health Stroke Scale score 5 [4\u20138]). Favorable outcome occurred in 63.6% of patients with EVT(\u00b1IVT) and in 64.3% of patients with IVT alone (adjusted odds ratio [OR] 0.89, 95% CI 0.46\u20131.72). There was an association of EVT(\u00b1IVT) with unfavorable distribution of the mRS (adjusted OR 1.83, 95% CI 1.10\u20133.06), and mortality was higher in the EVT(\u00b1IVT) group (15.9% versus 6.1%, adjusted OR 3.38, 95% confidence interval 1.30\u20138.75). Rates of symptomatic intracranial hemorrhage did not differ between groups (2.0% versus 0%). The results remained unchanged after additional inverse probability of treatment weighting analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this multicenter observational cohort study, EVT(\u00b1IVT) in patients with basilar artery occlusion with mild\u2010to\u2010moderate stroke, was not associated with improved clinical outcome but higher mortality compared with IVT\u2010treatment. Our findings underscore equipoise and the need for prospective trials in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.002059","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:29:56Z","timestamp":1761748196000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild\u2010to\u2010Moderate Severe Stroke"],"prefix":"10.1161","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-0242","authenticated-orcid":false,"given":"Simone","family":"Lieschke","sequence":"first","affiliation":[{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Riegler","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam R.","family":"Heldner","sequence":"additional","affiliation":[{"name":"Bern University Hospital and University of Bern","place":["Bern, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS di Reggio Emilia","place":["Reggio Emilia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zini","sequence":"additional","affiliation":[{"name":"Maggiore Hospital","place":["Bologna, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Gensicke","sequence":"additional","affiliation":[{"name":"University Department of Geriatric Medicine FELIX PLATTER, University of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital Basel and University of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerian L.","family":"Altersberger","sequence":"additional","affiliation":[{"name":"University Hospital Basel and University of Basel","place":["Basel, Switzerland"]},{"name":"Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Inauen","sequence":"additional","affiliation":[{"name":"University Hospital Zurich and University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Puy","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, UMR\u2010S1172 \u2010 LilNCog \u2010 Lille Neuroscience & Cognition","place":["Lille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Arthur","family":"Ringleb","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Salerno","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital and University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"B\u00e9jot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, University Hospital of Dijon","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pezzini","sequence":"additional","affiliation":[{"name":"University of Parma","place":["Parma, Italy"]},{"name":"Parma University Hospital","place":["Parma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visnja","family":"Padjen","sequence":"additional","affiliation":[{"name":"University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa","family":"Metanis","sequence":"additional","affiliation":[{"name":"Hadassah\u2010Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Marto","sequence":"additional","affiliation":[{"name":"Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Nederkoorn","sequence":"additional","affiliation":[{"name":"University of Amsterdam","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo W.","family":"Cereda","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland","place":["Lugano, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Bigliardi","sequence":"additional","affiliation":[{"name":"Modena University Hospital","place":["Modena, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich J.","family":"Audebert","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[{"name":"Inselspital, Bern University Hospital and University of Bern","place":["Bern, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Pascarella","sequence":"additional","affiliation":[{"name":"Ospedale Santa Maria della Misericordia, AULSS 5 Polesana","place":["Rovigo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Maggiore Hospital","place":["Bologna, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Truessel","sequence":"additional","affiliation":[{"name":"University Department of Geriatric Medicine FELIX PLATTER, University of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital Basel and University of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Engelter","sequence":"additional","affiliation":[{"name":"University Department of Geriatric Medicine FELIX PLATTER, University of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital Basel and University of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Wegener","sequence":"additional","affiliation":[{"name":"University Hospital Zurich and University of Zurich","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, UMR\u2010S1172 \u2010 LilNCog \u2010 Lille Neuroscience & Cognition","place":["Lille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sch\u00f6nenberger","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Saliou","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital and University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier","family":"Duloquin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, University Hospital of Dijon","place":["Dijon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Magoni","sequence":"additional","affiliation":[{"name":"ASST Spedali Civili","place":["Brescia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Stanarcevic","sequence":"additional","affiliation":[{"name":"University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen R.","family":"Leker","sequence":"additional","affiliation":[{"name":"Hadassah\u2010Hebrew University Medical Center","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Mendes Ferreira","sequence":"additional","affiliation":[{"name":"Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Wali","sequence":"additional","affiliation":[{"name":"University of Amsterdam","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Benci","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland","place":["Lugano, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rosafio","sequence":"additional","affiliation":[{"name":"Modena University Hospital","place":["Modena, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"University of Thessaly","place":["Larissa, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H.","family":"Nolte","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin","place":["Berlin, Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner site Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F.","family":"Scheitz","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin","place":["Berlin, Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner site Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TRISP and EVA\u2010TRISP collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70229-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040807"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002129"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.2.227"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30395-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030297"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207576"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206317"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(24)01820-8","article-title":"Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta\u2010analysis","volume":"405","author":"Nogueira RG","year":"2024","unstructured":"Nogueira RG, Jovin TG, Liu X, Hu W, Langezaal LCM, Li C, Dai Q, Tao C, Mont'Alverne FJA, Ji X, et\u00a0al. Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta\u2010analysis. Lancet [Internet]. 2024;405:61\u201069.","journal-title":"Lancet"},{"key":"e_1_3_2_12_2","article-title":"European stroke organisation and European society for minimally invasive neurological therapy guideline on acute management of basilar artery occlusion","volume":"16","author":"Strbian D","year":"2024","unstructured":"Strbian D, Tsivgoulis G, Ospel J, R\u00e4ty S, Cimflova P, Georgiopoulos G, Ullberg T, Arquizan C, Gralla J, Zele\u0148\u00e1k K, et\u00a0al. European stroke organisation and European society for minimally invasive neurological therapy guideline on acute management of basilar artery occlusion. Eur Stroke J. 2024;16:e7.","journal-title":"Eur Stroke J"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-042211"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023265"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034480"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042674"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.687134","article-title":"Comparison of risk factors, safety, and efficacy outcomes of mechanical thrombectomy in posterior vs. anterior circulation large vessel occlusion","volume":"12","author":"Mbroh J","year":"2021","unstructured":"Mbroh J, Poli K, T\u00fcnnerhoff J, Gomez\u2010Exposito A, Wang Y, Bender B, Hempel JM, Hennersdorf F, Feil K, Mengel A, et\u00a0al. Comparison of risk factors, safety, and efficacy outcomes of mechanical thrombectomy in posterior vs. anterior circulation large vessel occlusion. Front Neurol. 2021;12:687134.","journal-title":"Front Neurol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2022.03755"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030992"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/23969873241290442","article-title":"Endovascular treatment versus medical management for basilar artery occlusion with low\u2010to\u2010moderate symptoms (National Institutes of Health Stroke Scale < 10)","volume":"10","author":"Dargazanli C","year":"2024","unstructured":"Dargazanli C, Mourand I, Mahmoudi M, Poirier L, Labreuche J, Weisenburger\u2010Lile D, Gory B, Richard S, Ducroux C, Piotin M, et\u00a0al. Endovascular treatment versus medical management for basilar artery occlusion with low\u2010to\u2010moderate symptoms (National Institutes of Health Stroke Scale < 10). Eur Stroke J. 2024;10:397\u2010405.","journal-title":"Eur Stroke J"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209249","article-title":"IV thrombolysis in basilar artery occlusion","volume":"102","author":"R\u00e4ty S","year":"2024","unstructured":"R\u00e4ty S, Virtanen P, Ritvonen J, Georgiopoulos G, Sairanen T, Lindsberg PJ, Strbian D. IV thrombolysis in basilar artery occlusion. Neurology. 2024;102:e209249.","journal-title":"Neurology"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231154797"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.034019"}],"container-title":["Stroke: Vascular and Interventional Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/SVIN.125.002059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:39:20Z","timestamp":1763609960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/SVIN.125.002059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1161\/SVIN.125.002059"],"URL":"https:\/\/doi.org\/10.1161\/svin.125.002059","relation":{},"ISSN":["2694-5746"],"issn-type":[{"value":"2694-5746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002059"}}